Functional gamma-secretase complex assembly in Golgi/trans-Golgi network: interactions among presenilin, nicastrin, Aph1, Pen-2, and gamma-secretase substrates
about
Pro-inflammatory interleukin-18 increases Alzheimer's disease-associated amyloid-β production in human neuron-like cellsSorting of the Alzheimer's disease amyloid precursor protein mediated by the AP-4 complexAssociation of gamma-secretase with lipid rafts in post-Golgi and endosome membranes.Enhancing CNS repair in neurological disease: challenges arising from neurodegeneration and rewiring of the networkAlzheimer's Disease and Hippocampal Adult Neurogenesis; Exploring Shared MechanismsGamma-secretase complex assembly within the early secretory pathwaySynaptic and endosomal localization of active gamma-secretase in rat brain.Cellular distribution of gamma-secretase subunit nicastrin in the developing and adult rat brains.Genetics of Alzheimer disease in the pre- and post-GWAS eraCalsyntenin-1 mediates axonal transport of the amyloid precursor protein and regulates Aβ productionGenetics of Alzheimer diseaseAmyloid precursor protein (APP) processing genes and cerebrospinal fluid APP cleavage product levels in Alzheimer's diseasePhysiology and pathology of endosome-to-Golgi retrograde sorting.Alterations of zinc transporter proteins ZnT-1, ZnT-4 and ZnT-6 in preclinical Alzheimer's disease brain.Cerebrospinal fluid Aβ42 levels and APP processing pathway genes in Parkinson's disease.Moonlighting activity of presenilin in plants is independent of gamma-secretase and evolutionarily conserved.Presenilin function and gamma-secretase activity.Alternative Splicing in Alzheimer's DiseaseThe role of the innate immune system in Alzheimer's disease and frontotemporal lobar degeneration: an eye on microglia.Substrate specificity of gamma-secretase and other intramembrane proteases.Structural and Functional Determinants of gamma-Secretase, an Intramembrane Protease Implicated in Alzheimer's Disease.Association of cerebrospinal fluid Aβ42 with A2M gene in cognitively normal subjects.Neprilysin and Aβ Clearance: Impact of the APP Intracellular Domain in NEP Regulation and Implications in Alzheimer's DiseaseAPP Function and Lipids: A Bidirectional Link.Advances and perspectives from genetic research: development of biological markers in Alzheimer's disease.Membrane trafficking pathways in Alzheimer's disease.Neurodegeneration in Alzheimer disease: role of amyloid precursor protein and presenilin 1 intracellular signaling.The very many faces of presenilins and the γ-secretase complex.Identification of new Presenilin-1 phosphosites: implication for γ-secretase activity and Aβ production.Pen-2 is essential for γ-secretase complex stability and trafficking but partially dispensable for endoproteolysis.Turnover of C99 is controlled by a crosstalk between ERAD and ubiquitin-independent lysosomal degradation in human neuroglioma cells.Rer1p competes with APH-1 for binding to nicastrin and regulates gamma-secretase complex assembly in the early secretory pathway.gamma-Secretase complexes containing N- and C-terminal fragments of different presenilin origin retain normal gamma-secretase activity.Conformational targeting of intracellular Aβ oligomers demonstrates their pathological oligomerization inside the endoplasmic reticulum.Aph-1 contributes to the stabilization and trafficking of the gamma-secretase complex through mechanisms involving intermolecular and intramolecular interactions.Functional overexpression of gamma-secretase reveals protease-independent trafficking functions and a critical role of lipids for protease activity.Presenilins and gamma-secretase inhibitors affect intracellular trafficking and cell surface localization of the gamma-secretase complex components.Amyloid Precursor Protein (APP) May Act as a Substrate and a Recognition Unit for CRL4CRBN and Stub1 E3 Ligases Facilitating Ubiquitination of Proteins Involved in Presynaptic Functions and NeurodegenerationIdentification of trans-golgi network proteins in Arabidopsis thaliana root tissue.Quantification of gamma-secretase modulation differentiates inhibitor compound selectivity between two substrates Notch and amyloid precursor protein
P2860
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P2860
Functional gamma-secretase complex assembly in Golgi/trans-Golgi network: interactions among presenilin, nicastrin, Aph1, Pen-2, and gamma-secretase substrates
description
2003 nî lūn-bûn
@nan
2003 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Functional gamma-secretase com ...... and gamma-secretase substrates
@ast
Functional gamma-secretase com ...... and gamma-secretase substrates
@en
Functional gamma-secretase com ...... and gamma-secretase substrates
@nl
type
label
Functional gamma-secretase com ...... and gamma-secretase substrates
@ast
Functional gamma-secretase com ...... and gamma-secretase substrates
@en
Functional gamma-secretase com ...... and gamma-secretase substrates
@nl
altLabel
Functional γ-secretase complex ...... -2, and γ-secretase substrates
@ast
Functional γ-secretase complex ...... -2, and γ-secretase substrates
@en
prefLabel
Functional gamma-secretase com ...... and gamma-secretase substrates
@ast
Functional gamma-secretase com ...... and gamma-secretase substrates
@en
Functional gamma-secretase com ...... and gamma-secretase substrates
@nl
P2093
P3181
P1476
Functional gamma-secretase com ...... and gamma-secretase substrates
@en
P2093
Dennis J Selkoe
Jennifer Strahle
Matthew J LaVoie
Michael S Wolfe
W Taylor Kimberly
Weiming Xia
P304
P3181
P356
10.1016/S0969-9961(03)00123-2
P407
P577
2003-11-01T00:00:00Z