2-amino-N-{4-[5-(2-phenanthrenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]-phenyl} acetamide (OSU-03012), a celecoxib derivative, directly targets p21-activated kinase
about
Approaches of targeting Rho GTPases in cancer drug discoveryBRAF activates and physically interacts with PAK to regulate cell motilityPak2 regulates hematopoietic progenitor cell proliferation, survival, and differentiationp21-Activated kinase inhibitors: a patent reviewMolecular pathways: targeting p21-activated kinase 1 signaling in cancer--opportunities, challenges, and limitationsPAK as a therapeutic target in gastric cancerAn isoform-selective, small-molecule inhibitor targets the autoregulatory mechanism of p21-activated kinaseMicroRNA-7, a homeobox D10 target, inhibits p21-activated kinase 1 and regulates its functionsPAK signalling during the development and progression of cancerThe Novel Small Molecule Inhibitor, OSU-T315, Suppresses Vestibular Schwannoma and Meningioma Growth by Inhibiting PDK2 Function in the AKT Pathway ActivationGrowth inhibitory and anti-tumour activities of OSU-03012, a novel PDK-1 inhibitor, on vestibular schwannoma and malignant schwannoma cells.Discovery of novel anticancer therapeutics targeting the PI3K/Akt/mTOR pathway.Eradication of intracellular Francisella tularensis in THP-1 human macrophages with a novel autophagy inducing agentA Rac-Pak signaling pathway is essential for ErbB2-mediated transformation of human breast epithelial cancer cells.Development of p21 activated kinase-targeted multikinase inhibitors that inhibit thyroid cancer cell migration.Republished: tracing PAKs from GI inflammation to cancerTargeting Rho-GTPases in immune cell migration and inflammation.IPA-3 inhibits the growth of liver cancer cells by suppressing PAK1 and NF-κB activation.Eradication of intracellular Salmonella enterica serovar Typhimurium with a small-molecule, host cell-directed agentPAK1 as a therapeutic target.Prolactin-stimulated activation of ERK1/2 mitogen-activated protein kinases is controlled by PI3-kinase/Rac/PAK signaling pathway in breast cancer cells.Protein phosphatase 1 regulatory subunit 12A and catalytic subunit δ, new members in the phosphatidylinositide 3 kinase insulin-signaling pathway.p21-Activated kinase 1 coordinates aberrant cell survival and pericellular proteolysis in a three-dimensional culture model for premalignant progression of human breast cancer.Dysregulation of the phosphatidylinositol 3-kinase pathway in thyroid neoplasia.Sensitivity to the non-COX inhibiting celecoxib derivative, OSU03012, is p21(WAF1/CIP1) dependent.A tale of two Paks.Pak protein kinases and their role in cancer.Development of small-molecule inhibitors of the group I p21-activated kinases, emerging therapeutic targets in cancer.PAK signaling in cancer.Recent advances in the development of p21-activated kinase inhibitorsRAC1: an emerging therapeutic option for targeting cancer angiogenesis and metastasis.Tracing PAKs from GI inflammation to cancer.Antitumor mechanisms of targeting the PDK1 pathway in head and neck cancer.Molecular docking and molecular dynamics studies reveal structural basis of inhibition and selectivity of inhibitors EGCG and OSU-03012 toward glucose regulated protein-78 (GRP78) overexpressed in glioblastoma.Inhibiting p21-Activated Kinase Induces Cell Death in Vestibular Schwannoma and Meningioma via Mitotic Catastrophe.IPA3 non-specifically enhances phosphorylation of several proteins in human platelets.
P2860
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P2860
2-amino-N-{4-[5-(2-phenanthrenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]-phenyl} acetamide (OSU-03012), a celecoxib derivative, directly targets p21-activated kinase
description
2007 nî lūn-bûn
@nan
2007 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
2-amino-N-{4-[5-(2-phenanthren ...... y targets p21-activated kinase
@ast
2-amino-N-{4-[5-(2-phenanthren ...... y targets p21-activated kinase
@en
2-amino-N-{4-[5-(2-phenanthren ...... y targets p21-activated kinase
@nl
type
label
2-amino-N-{4-[5-(2-phenanthren ...... y targets p21-activated kinase
@ast
2-amino-N-{4-[5-(2-phenanthren ...... y targets p21-activated kinase
@en
2-amino-N-{4-[5-(2-phenanthren ...... y targets p21-activated kinase
@nl
prefLabel
2-amino-N-{4-[5-(2-phenanthren ...... y targets p21-activated kinase
@ast
2-amino-N-{4-[5-(2-phenanthren ...... y targets p21-activated kinase
@en
2-amino-N-{4-[5-(2-phenanthren ...... y targets p21-activated kinase
@nl
P2093
P356
P1476
2-amino-N-{4-[5-(2-phenanthren ...... y targets p21-activated kinase
@en
P2093
Allan V Espinosa
Ching-Shih Chen
Lawrence S Kirschner
Marcy Guerra
Matthew D Ringel
Motoo Shinohara
Motoyasu Saji
Samuel K Kulp
Yu-Chieh Wang
Yunlong Zhang
P304
P356
10.1124/MOL.107.037556
P407
P577
2007-08-02T00:00:00Z