Coamplification of the CDK4 gene with MDM2 and GLI in human sarcomas
about
Real-time PCR based on SYBR-Green I fluorescence: an alternative to the TaqMan assay for a relative quantification of gene rearrangements, gene amplifications and micro gene deletionsHDM2-binding partners: interaction with translation elongation factor EF1alpha.Growth suppression by p16ink4 requires functional retinoblastoma proteinDirect isolation of genes encoded within a homogeneously staining region by chromosome microdissectionArsenic antagonizes the Hedgehog pathway by preventing ciliary accumulation and reducing stability of the Gli2 transcriptional effectorMapping and characterization of the amplicon near APOA2 in 1q23 in human sarcomas by FISH and array CGHPost-transcriptional gene expression control by NANOS is up-regulated and functionally important in pRb-deficient cellsArsenic trioxide prevents osteosarcoma growth by inhibition of GLI transcription via DNA damage accumulationAnalysis of molecular cytogenetic alteration in rhabdomyosarcoma by array comparative genomic hybridizationHuman rhabdomyosarcoma cell lines for rhabdomyosarcoma research: utility and pitfalls.Overexpression of Mdm2 in mice reveals a p53-independent role for Mdm2 in tumorigenesis.Cell cycle control, checkpoint mechanisms, and genotoxic stress.Cell cycle regulation of the cyclin A gene promoter is mediated by a variant E2F siteHuman T-cell leukemia virus type 1 Tax and cell cycle progression: role of cyclin D-cdk and p110Rb.The human oncoprotein MDM2 arrests the cell cycle: elimination of its cell-cycle-inhibitory function induces tumorigenesisTransforming activity of Fbxo7 is mediated specifically through regulation of cyclin D/cdk6.Invasive melanoma in Cdk4-targeted mice.Betulinic acid induces apoptosis and inhibits hedgehog signalling in rhabdomyosarcoma.Wide spectrum of tumors in knock-in mice carrying a Cdk4 protein insensitive to INK4 inhibitors.The history and future of targeting cyclin-dependent kinases in cancer therapy.p27KIP1 deletions in childhood acute lymphoblastic leukemia.Application of comparative genomic hybridization, spectral karyotyping, and microarray analysis in the identification of subtype-specific patterns of genomic changes in rhabdomyosarcoma.Novel candidate key drivers in the integrative network of genes, microRNAs, methylations, and copy number variations in squamous cell lung carcinoma.Cyclin D2 overexpression and lack of p27 correlate positively and cyclin E inversely with a poor prognosis in gastric cancer cases.Cdk4 deficiency inhibits skin tumor development but does not affect normal keratinocyte proliferation.DNA copy number amplifications in human neoplasms: review of comparative genomic hybridization studies.Is the EWS/FLI-1 fusion transcript specific for Ewing sarcoma and peripheral primitive neuroectodermal tumor? A report of four cases showing this transcript in a wider range of tumor typesMolecular genetic aspects of oligodendrogliomas including analysis by comparative genomic hybridization.Analysis of genomic alterations in sporadic adrenocortical lesions. Gain of chromosome 17 is an early event in adrenocortical tumorigenesis.Gene amplification and overexpression of CDK4 in sporadic breast carcinomas is associated with high tumor cell proliferation.Cdk4 disruption renders primary mouse cells resistant to oncogenic transformation, leading to Arf/p53-independent senescence.Amplification of the MDM2 gene in human breast cancer and its association with MDM2 and p53 protein status.Homozygous deletion frequency and expression levels of the CDKN2 gene in human sarcomas--relationship to amplification and mRNA levels of CDK4 and CCND1.CDK4 Amplification Reduces Sensitivity to CDK4/6 Inhibition in Fusion-Positive RhabdomyosarcomaInvolvement of the pRb/p16/cdk4/cyclin D1 pathway in the tumorigenesis of sporadic malignant melanomas.A dimeric mutant of human pancreatic ribonuclease with selective cytotoxicity toward malignant cells.Inhibition of p53-mediated growth arrest by overexpression of cyclin-dependent kinasesEfficacy of CDK4 inhibition against sarcomas depends on their levels of CDK4 and p16ink4 mRNA.Comparison of deregulated expression of cyclin D1 and cyclin E with that of cyclin-dependent kinase 4 (CDK4) and CDK2 in human oesophageal squamous cell carcinomap53 missense but not truncation mutations are associated with low levels of p21(CIP1/WAF1) mRNA expression in primary human sarcomas.
P2860
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P2860
Coamplification of the CDK4 gene with MDM2 and GLI in human sarcomas
description
1993 nî lūn-bûn
@nan
1993 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
1993 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
1993年の論文
@ja
1993年論文
@yue
1993年論文
@zh-hant
1993年論文
@zh-hk
1993年論文
@zh-mo
1993年論文
@zh-tw
1993年论文
@wuu
name
Coamplification of the CDK4 gene with MDM2 and GLI in human sarcomas
@ast
Coamplification of the CDK4 gene with MDM2 and GLI in human sarcomas
@en
Coamplification of the CDK4 gene with MDM2 and GLI in human sarcomas
@nl
type
label
Coamplification of the CDK4 gene with MDM2 and GLI in human sarcomas
@ast
Coamplification of the CDK4 gene with MDM2 and GLI in human sarcomas
@en
Coamplification of the CDK4 gene with MDM2 and GLI in human sarcomas
@nl
prefLabel
Coamplification of the CDK4 gene with MDM2 and GLI in human sarcomas
@ast
Coamplification of the CDK4 gene with MDM2 and GLI in human sarcomas
@en
Coamplification of the CDK4 gene with MDM2 and GLI in human sarcomas
@nl
P2093
P1433
P1476
Coamplification of the CDK4 gene with MDM2 and GLI in human sarcomas
@en
P2093
P304
P407
P577
1993-11-01T00:00:00Z