Regulation of the matriptase-prostasin cell surface proteolytic cascade by hepatocyte growth factor activator inhibitor-1 during epidermal differentiation
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Reduced prostasin (CAP1/PRSS8) activity eliminates HAI-1 and HAI-2 deficiency-associated developmental defects by preventing matriptase activationGene expression correlations in human cancer cell lines define molecular interaction networks for epithelial phenotypeHuman cancer cells retain modest levels of enzymatically active matriptase only in extracellular milieu following induction of zymogen activationMatriptase autoactivation is tightly regulated by the cellular chemical environmentsMolecular constituents of the extracellular matrix in rat liver mounting a hepatic progenitor cell response for tissue repair.The membrane-anchored serine protease prostasin (CAP1/PRSS8) supports epidermal development and postnatal homeostasis independent of its enzymatic activity.Targeting zymogen activation to control the matriptase-prostasin proteolytic cascade.The protease inhibitor HAI-2, but not HAI-1, regulates matriptase activation and shedding through prostasin.Transport via the transcytotic pathway makes prostasin available as a substrate for matriptaseIncreased matriptase zymogen activation in inflammatory skin disorders.Antithrombin regulates matriptase activity involved in plasmin generation, syndecan shedding, and HGF activation in keratinocytes.Differential subcellular localization renders HAI-2 a matriptase inhibitor in breast cancer cells but not in mammary epithelial cellsMatriptase is inhibited by extravascular antithrombin in epithelial cells but not in most carcinoma cellsProstasin: An Epithelial Sodium Channel Regulator.Mechanisms for the control of matriptase activity in the absence of sufficient HAI-1Natural Endogenous Human Matriptase and Prostasin Undergo Zymogen Activation via Independent Mechanisms in an Uncoupled Manner.Selective Inhibition of Prostasin in Human Enterocytes by the Integral Membrane Kunitz-Type Serine Protease Inhibitor HAI-2Cleavage activation of the human-adapted influenza virus subtypes by matriptase reveals both subtype and strain specificities.Distinct Developmental Functions of Prostasin (CAP1/PRSS8) Zymogen and Activated ProstasinProstasin is required for matriptase activation in intestinal epithelial cells to regulate closure of the paracellular pathway.A matriptase-prostasin reciprocal zymogen activation complex with unique features: prostasin as a non-enzymatic co-factor for matriptase activation.Matriptase and prostasin are expressed in human skin in an inverse trend over the course of differentiation and are targeted to different regions of the plasma membrane.Matriptase expression and zymogen activation in human pilosebaceous unit.Matriptase regulates proliferation and early, but not terminal, differentiation of human keratinocytesThe matriptase-prostasin proteolytic cascade in epithelial development and pathology.The basal chorionic trophoblast cell layer: An emerging coordinator of placenta development.Deregulated matriptase activity in oral squamous cell carcinoma promotes the infiltration of cancer-associated fibroblasts by paracrine activation of protease-activated receptor 2.Hepatocyte growth factor activator inhibitor type 1 maintains the assembly of keratin into desmosomes in keratinocytes by regulating protease-activated receptor 2-dependent p38 signaling.Regulation of pericellular proteolysis by hepatocyte growth factor activator inhibitor type 1 (HAI-1) in trophoblast cells.Loss of membrane-bound serine protease inhibitor HAI-1 induces oral squamous cell carcinoma cells' invasiveness.Strong expression association between matriptase and its substrate prostasin in breast cancer.Matriptase shedding is closely coupled with matriptase zymogen activation and requires de novo proteolytic cleavage likely involving its own activity.Down-regulation of HAI-1 is associated with poor-differentiation status of colorectal cancer.Tissue distribution and subcellular localizations determine in vivo functional relationship among prostasin, matriptase, HAI-1, and HAI-2 in human skin.Deregulated hepsin protease activity confers oncogenicity by concomitantly augmenting HGF/MET signalling and disrupting epithelial cohesion.
P2860
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P2860
Regulation of the matriptase-prostasin cell surface proteolytic cascade by hepatocyte growth factor activator inhibitor-1 during epidermal differentiation
description
2010 nî lūn-bûn
@nan
2010 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Regulation of the matriptase-p ...... ring epidermal differentiation
@ast
Regulation of the matriptase-p ...... ring epidermal differentiation
@en
Regulation of the matriptase-p ...... ring epidermal differentiation
@nl
type
label
Regulation of the matriptase-p ...... ring epidermal differentiation
@ast
Regulation of the matriptase-p ...... ring epidermal differentiation
@en
Regulation of the matriptase-p ...... ring epidermal differentiation
@nl
prefLabel
Regulation of the matriptase-p ...... ring epidermal differentiation
@ast
Regulation of the matriptase-p ...... ring epidermal differentiation
@en
Regulation of the matriptase-p ...... ring epidermal differentiation
@nl
P2093
P2860
P356
P1476
Regulation of the matriptase-p ...... ring epidermal differentiation
@en
P2093
Chen-Yong Lin
Chiu-Yuan Chen
Ellen A Rorke
Feng-Pai Chou
Jehng-Kang Wang
Karl X Chai
Li-Mei Chen
Michael D Johnson
Richard L Eckert
Ya-Wen Chen
P2860
P304
31755-31762
P356
10.1074/JBC.M110.150367
P407
P577
2010-08-09T00:00:00Z