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Leucine-rich repeat kinase 2 regulates autophagy through a calcium-dependent pathway involving NAADPDysregulation of lysosomal morphology by pathogenic LRRK2 is corrected by TPC2 inhibitionMetabolism of the novel Ca2+-mobilizing messenger nicotinic acid-adenine dinucleotide phosphate via a 2'-specific Ca2+-dependent phosphatasePhotoaffinity labeling of nicotinic acid adenine dinucleotide phosphate (NAADP) targets in mammalian cellsCa2+/H+ exchange by acidic organelles regulates cell migration in vivo.Two-pore channels at the intersection of endolysosomal membrane trafficSperm deliver a new second messenger: NAADPNAADP mobilizes Ca(2+) from reserve granules, lysosome-related organelles, in sea urchin eggsRole of NAADP and cADPR in the induction and maintenance of agonist-evoked Ca2+ spiking in mouse pancreatic acinar cellsMembrane potential regulates nicotinic acid adenine dinucleotide phosphate (NAADP) dependence of the pH- and Ca2+-sensitive organellar two-pore channel TPC1An NAADP-gated two-pore channel targeted to the plasma membrane uncouples triggering from amplifying Ca2+ signalsMessenger-specific role for nicotinic acid adenine dinucleotide phosphate in neuronal differentiationConvergent regulation of the lysosomal two-pore channel-2 by Mg²⁺, NAADP, PI(3,5)P₂ and multiple protein kinasesMolecular characterization of a novel cell surface ADP-ribosyl cyclase from the sea urchin.Molecular characterization of a novel intracellular ADP-ribosyl cyclase.NAADP-induced calcium release in sea urchin eggs.Acidic NAADP-sensitive calcium stores in the endothelium: agonist-specific recruitment and role in regulating blood pressure.Function and dysfunction of two-pore channels.The Two-pore channel (TPC) interactome unmasks isoform-specific roles for TPCs in endolysosomal morphology and cell pigmentationMembrane topology of NAADP-sensitive two-pore channels and their regulation by N-linked glycosylation.NAD kinase controls animal NADP biosynthesis and is modulated via evolutionarily divergent calmodulin-dependent mechanismsTransient receptor potential mucolipin 1 (TRPML1) and two-pore channels are functionally independent organellar ion channelsTwo-pore channels provide insight into the evolution of voltage-gated Ca2+ and Na+ channels.Transgenic mice expressing a cameleon fluorescent Ca2+ indicator in astrocytes and Schwann cells allow study of glial cell Ca2+ signals in situ and in vivoInsights into the early evolution of animal calcium signaling machinery: a unicellular point of viewNAADP-induced Ca2+ release -- a new signalling pathway.The intracellular Ca²⁺ channels of membrane traffic.In with the TRP channels: intracellular functions for TRPM1 and TRPM2.The endo-lysosomal system as an NAADP-sensitive acidic Ca(2+) store: role for the two-pore channels.NAADP on target.A link between LRRK2, autophagy and NAADP-mediated endolysosomal calcium signalling.Evolution of acidic Ca²⁺ stores and their resident Ca²⁺-permeable channels.Calcium signaling at ER membrane contact sites.Solubilization of receptors for the novel Ca2+-mobilizing messenger, nicotinic acid adenine dinucleotide phosphate.Endoplasmic reticulum and lysosomal Ca²⁺ stores are remodelled in GBA1-linked Parkinson disease patient fibroblasts.Coupling acidic organelles with the ER through Ca²⁺ microdomains at membrane contact sites.Probing the Complexities of Astrocyte Calcium Signaling.Signalling at membrane contact sites: two membranes come together to handle second messengers.NAADP-sensitive two-pore channels are present and functional in gastric smooth muscle cells.Endo-lysosomal TRP mucolipin-1 channels trigger global ER Ca2+ release and Ca2+ influx.
P50
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P50
description
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Sandip Patel
@ast
Sandip Patel
@en
Sandip Patel
@es
Sandip Patel
@nl
Sandip Patel
@sl
সন্দীপ পাটেল
@bn
type
label
Sandip Patel
@ast
Sandip Patel
@en
Sandip Patel
@es
Sandip Patel
@nl
Sandip Patel
@sl
সন্দীপ পাটেল
@bn
prefLabel
Sandip Patel
@ast
Sandip Patel
@en
Sandip Patel
@es
Sandip Patel
@nl
Sandip Patel
@sl
সন্দীপ পাটেল
@bn
P1053
O-9591-2015
P106
P1153
7403902620
P31
P3829
P496
0000-0001-7247-2013
P569
2000-01-01T00:00:00Z