Haploinsufficiency for the neurofibromatosis 1 (NF1) tumor suppressor results in increased astrocyte proliferation
about
Mouse models of neurofibromatosis 1 and 2.RASopathies: unraveling mechanisms with animal modelsAblation of NF1 function in neurons induces abnormal development of cerebral cortex and reactive gliosis in the brainNeurofibromatosis 1 (NF1) heterozygosity results in a cell-autonomous growth advantage for astrocytesZebrafish neurofibromatosis type 1 genes have redundant functions in tumorigenesis and embryonic development.Haploinsufficiency of Anx7 tumor suppressor gene and consequent genomic instability promotes tumorigenesis in the Anx7(+/-) mouseThe NF1 somatic mutational landscape in sporadic human cancers.Haploinsufficient tumor suppressor genes.The NF1 gene revisited - from bench to bedside.Neurofibromatosis type 1: modeling CNS dysfunction.Astrocyte-specific inactivation of the neurofibromatosis 1 gene (NF1) is insufficient for astrocytoma formation.Cardiovascular disease in neurofibromatosis 1: report of the NF1 Cardiovascular Task Force.T-cadherin-mediated cell growth regulation involves G2 phase arrest and requires p21(CIP1/WAF1) expressionNeurofibromatosis 1: clinical manifestations and diagnostic criteria.Neurofibromin in the brain.Schweinfurthin A selectively inhibits proliferation and Rho signaling in glioma and neurofibromatosis type 1 tumor cells in a NF1-GRD-dependent manner.Comparative oncogenomics implicates the neurofibromin 1 gene (NF1) as a breast cancer driver.Inactivation of NF1 in CNS causes increased glial progenitor proliferation and optic glioma formation.Role of NF2 haploinsufficiency in NF2-associated polyneuropathy.Functional allelic loss detected at the protein level in archival human tumours using allele-specific E-cadherin monoclonal antibodies.Human stem cell modeling in neurofibromatosis type 1 (NF1).Oligodendrocyte progenitor cell numbers and migration are regulated by the zebrafish orthologs of the NF1 tumor suppressor geneThe rules and impact of nonsense-mediated mRNA decay in human cancers.Neurofibromatosis and lessons for the war on cancer.Regulation of the viability of Nf1 deficient cells by PKC isoforms.Nf1+/- mice have increased neointima formation via hyperactivation of a Gleevec sensitive molecular pathway.Autopsy case of concurrent Huntington's disease and neurofibromatosis type 1.Mutational and expression analysis of the NF1 gene argues against a role as tumor suppressor in sporadic pilocytic astrocytomas.Heterozygosity for the tuberous sclerosis complex (TSC) gene products results in increased astrocyte numbers and decreased p27-Kip1 expression in TSC2+/- cells.Distinction in gene expression profiles of oligodendrogliomas with and without allelic loss of 1p.Astrocyte-specific expression of CDK4 is not sufficient for tumor formation, but cooperates with p53 heterozygosity to provide a growth advantage for astrocytes in vivo.Macrocephaly in neurofibromatosis type 1: a sign post for optic pathway gliomas?Mek1Y130C mice recapitulate aspects of human cardio-facio-cutaneous syndrome.Loss of neurofibromin is associated with activation of RAS/MAPK and PI3-K/AKT signaling in a neurofibromatosis 1 astrocytoma.Loss of neurofibromatosis 1 (NF1) gene expression in NF1-associated pilocytic astrocytomas.
P2860
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P2860
Haploinsufficiency for the neurofibromatosis 1 (NF1) tumor suppressor results in increased astrocyte proliferation
description
1999 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 1999
@ast
im August 1999 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 1999/08/05)
@sk
vědecký článek publikovaný v roce 1999
@cs
wetenschappelijk artikel (gepubliceerd op 1999/08/05)
@nl
наукова стаття, опублікована в серпні 1999
@uk
مقالة علمية (نشرت في 5-8-1999)
@ar
name
Haploinsufficiency for the neu ...... reased astrocyte proliferation
@ast
Haploinsufficiency for the neu ...... reased astrocyte proliferation
@en
Haploinsufficiency for the neu ...... reased astrocyte proliferation
@nl
type
label
Haploinsufficiency for the neu ...... reased astrocyte proliferation
@ast
Haploinsufficiency for the neu ...... reased astrocyte proliferation
@en
Haploinsufficiency for the neu ...... reased astrocyte proliferation
@nl
prefLabel
Haploinsufficiency for the neu ...... reased astrocyte proliferation
@ast
Haploinsufficiency for the neu ...... reased astrocyte proliferation
@en
Haploinsufficiency for the neu ...... reased astrocyte proliferation
@nl
P2093
P921
P356
P1433
P1476
Haploinsufficiency for the neu ...... reased astrocyte proliferation
@en
P2093
P2888
P304
P356
10.1038/SJ.ONC.1202829
P407
P577
1999-08-05T00:00:00Z
P5875
P6179
1038208030