Astrocyte-specific inactivation of the neurofibromatosis 1 gene (NF1) is insufficient for astrocytoma formation. - Wikidata - wikimedia - TriplyDB

Astrocyte-specific inactivation of the neurofibromatosis 1 gene (NF1) is insufficient for astrocytoma formation.

Astrocyte-specific inactivation of the neurofibromatosis 1 gene (NF1) is insufficient for astrocytoma formation.

http://www.wikidata.org/entity/Q34441257

about

Phosphatase and tensin homolog, deleted on chromosome 10 deficiency in brain causes defects in synaptic structure, transmission and plasticity, and myelination abnormalities Tumor microenvironment and neurofibromatosis type I: connecting the GAPs RASopathies: unraveling mechanisms with animal models Eliminating barriers to personalized medicine: learning from neurofibromatosis type 1 MAPK pathway activation in pilocytic astrocytoma Neurofibromatosis type 1 - a model for nervous system tumour formation?Delta-like 1 regulates Bergmann glial monolayer formation during cerebellar development Oncogenic Kras expression in postmitotic neurons leads to S100A8-S100A9 protein overexpression and gliosis Astrocyte-derived vascular endothelial growth factor stabilizes vessels in the developing retinal vasculature Astrocytes as determinants of disease progression in inherited amyotrophic lateral sclerosis Optimizing biologically targeted clinical trials for neurofibromatosis.Modulation of astrocyte glutamate transporters decreases seizures in a mouse model of Tuberous Sclerosis Complex.Reduced striatal dopamine underlies the attention system dysfunction in neurofibromatosis-1 mutant mice.Tsc2 gene inactivation causes a more severe epilepsy phenotype than Tsc1 inactivation in a mouse model of tuberous sclerosis complex.Excessive activation of mTOR in postnatally generated granule cells is sufficient to cause epilepsy.NF1 is a critical regulator of muscle development and metabolism Astrocytic adenosine receptor A2A and Gs-coupled signaling regulate memory.Generation of a mouse model of atypical teratoid/rhabdoid tumor of the central nervous system through combined deletion of Snf5 and p53.Cell type specificity of PI3K signaling in Pdk1- and Pten-deficient brains The genomic landscape of diffuse intrinsic pontine glioma and pediatric non-brainstem high-grade glioma Act1 mediates IL-17-induced EAE pathogenesis selectively in NG2+ glial cells Mast cells and the neurofibroma microenvironment Ultrastructural characterization of the optic pathway in a mouse model of neurofibromatosis-1 optic glioma Sexually dimorphic RB inactivation underlies mesenchymal glioblastoma prevalence in males Using the neurofibromatosis tumor predisposition syndromes to understand normal nervous system development.Finding degrees of separation: experimental approaches for astroglial and oligodendroglial cell isolation and genetic targeting Neurofibromatosis type 1: modeling CNS dysfunction.Apolipoprotein E4 produced in GABAergic interneurons causes learning and memory deficits in mice Early inactivation of p53 tumor suppressor gene cooperating with NF1 loss induces malignant astrocytoma.Neurofibromatosis-1 heterozygosity increases microglia in a spatially and temporally restricted pattern relevant to mouse optic glioma formation and growth.Neurofibromin regulation of ERK signaling modulates GABA release and learning.Neuropathology of genetically engineered mice: consensus report and recommendations from an international forum.Neurofibromin in the brain.Germ-line recombination activity of the widely used hGFAP-Cre and nestin-Cre transgenes.Hypoxia inducible factor-2α regulates the development of retinal astrocytic network by maintaining adequate supply of astrocyte progenitors Integrin-dependent and -independent functions of astrocytic fibronectin in retinal angiogenesis.Neurofibromatosis-1 regulates mTOR-mediated astrocyte growth and glioma formation in a TSC/Rheb-independent manner.Somatic neurofibromatosis type 1 (NF1) inactivation events in cutaneous neurofibromas of a single NF1 patient.Incidence of kiaa1549-braf fusion gene in Egyptian pediatric low grade glioma.Astrocyte pVHL and HIF-α isoforms are required for embryonic-to-adult vascular transition in the eye

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Astrocyte-specific inactivation of the neurofibromatosis 1 gene (NF1) is insufficient for astrocytoma formation.

http://www.wikidata.org/entity/Q34441257

description

2002 nî lūn-bûn

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2002 թուականի Յուլիսին հրատարակուած գիտական յօդուած

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2002 թվականի հուլիսին հրատարակված գիտական հոդված

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2002年の論文

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2002年論文

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2002年論文

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2002年論文

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2002年論文

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2002年論文

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2002年论文

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name

Astrocyte-specific inactivatio ...... ent for astrocytoma formation.

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Astrocyte-specific inactivatio ...... ent for astrocytoma formation.

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Astrocyte-specific inactivation of the neurofibromatosis 1 gene

@nl

type

label

Astrocyte-specific inactivatio ...... ent for astrocytoma formation.

@ast

Astrocyte-specific inactivatio ...... ent for astrocytoma formation.

@en

Astrocyte-specific inactivation of the neurofibromatosis 1 gene

@nl

prefLabel

Astrocyte-specific inactivatio ...... ent for astrocytoma formation.

@ast

Astrocyte-specific inactivatio ...... ent for astrocytoma formation.

@en

Astrocyte-specific inactivation of the neurofibromatosis 1 gene

@nl

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MCB.22.14.5100-5113.2002

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Molecular and Cellular Biology

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Astrocyte-specific inactivatio ...... ient for astrocytoma formation

@en

P2093

Jessica Donahoe

http://www.w3.org/2001/XMLSchema#string

Luis F Parada

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Michaela Livia Bajenaru

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Nicolé M Hedrick

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Yuan Zhu

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P2860

Aberrant regulation of ras proteins in malignant tumour cells from type 1 neurofibromatosis patients

The NF1 locus encodes a protein functionally related to mammalian GAP and yeast IRA proteins

Targeted disruption of the neurofibromatosis type-1 gene leads to developmental abnormalities in heart and various neural crest-derived tissues

A major segment of the neurofibromatosis type 1 gene: cDNA sequence, genomic structure, and point mutations

Ablation of NF1 function in neurons induces abnormal development of cerebral cortex and reactive gliosis in the brain

Neurofibromatosis 1 (NF1) heterozygosity results in a cell-autonomous growth advantage for astrocytes

Nf1;Trp53 mutant mice develop glioblastoma with evidence of strain-specific effects

Haploinsufficiency for the neurofibromatosis 1 (NF1) tumor suppressor results in increased astrocyte proliferation

Tumour predisposition in mice heterozygous for a targeted mutation in Nf1

The GAP-related domain of the neurofibromatosis type 1 gene product interacts with ras p21

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5100-5113

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10.1128/MCB.22.14.5100-5113.2002

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14

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22

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David H Gutmann

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2002-07-01T00:00:00Z

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12077339

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139771

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