Vascular abnormalities and deregulation of VEGF in Lkb1-deficient mice
about
Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascadeMO25alpha/beta interact with STRADalpha/beta enhancing their ability to bind, activate and localize LKB1 in the cytoplasmActivation of the tumour suppressor kinase LKB1 by the STE20-like pseudokinase STRADA positive feedback loop involving Gcm1 and Fzd5 directs chorionic branching morphogenesis in the placentaHeat-shock protein 90 and Cdc37 interact with LKB1 and regulate its stabilitySkeletal muscle-selective knockout of LKB1 increases insulin sensitivity, improves glucose homeostasis, and decreases TRB3Upregulated genes in sporadic, idiopathic pulmonary arterial hypertension.Targeting LKB1 in cancer - exposing and exploiting vulnerabilitiesCrystal structure of MO25 alpha in complex with the C terminus of the pseudo kinase STE20-related adaptorActivation of yeast Snf1 and mammalian AMP-activated protein kinase by upstream kinases.A role for LKB1 gene in human cancer beyond the Peutz-Jeghers syndromeIdentification and characterization of four novel phosphorylation sites (Ser31, Ser325, Thr336 and Thr366) on LKB1/STK11, the protein kinase mutated in Peutz-Jeghers cancer syndromeProtein kinase LKB1 regulates polarized dendrite formation of adult hippocampal newborn neuronsThe essential role of Cited2, a negative regulator for HIF-1alpha, in heart development and neurulationLKB1 is an essential regulator of spermatozoa release during spermiation in the mammalian testisThe LKB1-AMPK pathway: metabolism and growth control in tumour suppressionLKB1 Is Required for the Development and Maintenance of Stereocilia in Inner Ear Hair Cells in Mice.Skeletal muscle dysfunction in muscle-specific LKB1 knockout mice.The tumour suppressor LKB1 regulates myelination through mitochondrial metabolism.Endothelial SIRT1 prevents adverse arterial remodeling by facilitating HERC2-mediated degradation of acetylated LKB1.Mutations in STK11 gene in Czech Peutz-Jeghers patientsNo association between promoter polymorphism of STK11 gene and lung cancer risk in the Korean population.LKB1 deficiency in Tie2-Cre-expressing cells impairs ischemia-induced angiogenesis.The cyclin-dependent kinase inhibitor p21 is a crucial target for histone deacetylase 1 as a regulator of cellular proliferation.High prevalence of germline STK11 mutations in Hungarian Peutz-Jeghers Syndrome patients.STRADalpha deficiency results in aberrant mTORC1 signaling during corticogenesis in humans and miceRole of Lkb1, the causative gene of Peutz-Jegher's syndrome, in embryogenesis and polyposisInduction of cyclooxygenase-2 in a mouse model of Peutz-Jeghers polyposis.Transport in technicolor: mapping ATP-binding cassette transporters in sea urchin embryos.LKB1 is a central regulator of tumor initiation and pro-growth metabolism in ErbB2-mediated breast cancer.Protein kinase LKB1 promotes RAB7-mediated neuropilin-1 degradation to inhibit angiogenesis.The LKB1 tumor suppressor controls spindle orientation and localization of activated AMPK in mitotic epithelial cells.Recent progress on liver kinase B1 (LKB1): expression, regulation, downstream signaling and cancer suppressive function.The Peutz-Jeghers kinase LKB1 suppresses polyp growth from intestinal cells of a proglucagon-expressing lineage in miceTumor Suppressor Serine/Threonine Kinase LKB1 Expression, Not Kinase Activity, Increased in the Vascular Smooth Muscle Cells and Neointima in the Rat Carotid Artery Injury ModelLKB1, a protein kinase regulating cell proliferation and polarity.LKB1 (XEEK1) regulates Wnt signalling in vertebrate development.LKB1, the multitasking tumour suppressor kinaseMutation analysis of three genes encoding novel LKB1-interacting proteins, BRG1, STRADalpha, and MO25alpha, in Peutz-Jeghers syndromeLkb1 regulates cell cycle and energy metabolism in haematopoietic stem cells
P2860
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P2860
Vascular abnormalities and deregulation of VEGF in Lkb1-deficient mice
description
2001 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Science
@fr
artículu científicu espublizáu en 2001
@ast
im August 2001 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2001/08/17)
@sk
vědecký článek publikovaný v roce 2001
@cs
wetenschappelijk artikel (gepubliceerd op 2001/08/17)
@nl
наукова стаття, опублікована в серпні 2001
@uk
name
Vascular abnormalities and deregulation of VEGF in Lkb1-deficient mice
@ast
Vascular abnormalities and deregulation of VEGF in Lkb1-deficient mice
@en
Vascular abnormalities and deregulation of VEGF in Lkb1-deficient mice
@nl
type
label
Vascular abnormalities and deregulation of VEGF in Lkb1-deficient mice
@ast
Vascular abnormalities and deregulation of VEGF in Lkb1-deficient mice
@en
Vascular abnormalities and deregulation of VEGF in Lkb1-deficient mice
@nl
prefLabel
Vascular abnormalities and deregulation of VEGF in Lkb1-deficient mice
@ast
Vascular abnormalities and deregulation of VEGF in Lkb1-deficient mice
@en
Vascular abnormalities and deregulation of VEGF in Lkb1-deficient mice
@nl
P2093
P3181
P356
P1433
P1476
Vascular abnormalities and deregulation of VEGF in Lkb1-deficient mice
@en
P2093
Henkemeyer M
Korsisaari N
Ylikorkala A
P304
P3181
P356
10.1126/SCIENCE.1062074
P407
P577
2001-08-01T00:00:00Z