Keap1 recruits Neh2 through binding to ETGE and DLG motifs: characterization of the two-site molecular recognition model
about
Molecular basis of electrophilic and oxidative defense: promises and perils of Nrf2Role of Nrf2 in oxidative stress and toxicityStructure of the Keap1:Nrf2 interface provides mechanistic insight into Nrf2 signalingThe Cullin 3 substrate adaptor KLHL20 mediates DAPK ubiquitination to control interferon responsesp62/SQSTM1 is a target gene for transcription factor NRF2 and creates a positive feedback loop by inducing antioxidant response element-driven gene transcriptionCysteine-based regulation of the CUL3 adaptor protein Keap1Direct interaction between Nrf2 and p21(Cip1/WAF1) upregulates the Nrf2-mediated antioxidant responseCancer related mutations in NRF2 impair its recognition by Keap1-Cul3 E3 ligase and promote malignancyPhysiological significance of reactive cysteine residues of Keap1 in determining Nrf2 activityNRF2, a Key Regulator of Antioxidants with Two Faces towards CancerThe Nrf2/HO-1 Axis in Cancer Cell Growth and ChemoresistanceRedox Modulating NRF2: A Potential Mediator of Cancer Stem Cell ResistanceThe mutational landscape of hepatocellular carcinomaMolecular mechanisms of Nrf2 regulation and how these influence chemical modulation for disease interventionEffect of redox modulating NRF2 activators on chronic kidney diseaseConcerted action of Nrf2-ARE pathway, MRN complex, HMGB1 and inflammatory cytokines - implication in modification of radiation damageRedox control of microglial function: molecular mechanisms and functional significanceMicrosecond molecular dynamics simulations of intrinsically disordered proteins involved in the oxidative stress responseDifferent Electrostatic Potentials Define ETGE and DLG Motifs as Hinge and Latch in Oxidative Stress ResponseStructural analysis of the complex of Keap1 with a prothymosin α peptideStructural Basis for Cul3 Protein Assembly with the BTB-Kelch Family of E3 Ubiquitin LigasesKinetic, Thermodynamic, and Structural Characterizations of the Association between Nrf2-DLGex Degron and Keap1The Marburg virus VP24 protein interacts with Keap1 to activate the cytoprotective antioxidant response pathwayStructural and biochemical characterization of the KLHL3–WNK kinase interaction important in blood pressure regulationStructure of the BTB domain of Keap1 and its interaction with the triterpenoid antagonist CDDONrf2 and Notch Signaling in Lung Cancer: Near the CrossroadDiscovery of direct inhibitors of Keap1-Nrf2 protein-protein interaction as potential therapeutic and preventive agentsNegative regulation of the Nrf1 transcription factor by its N-terminal domain is independent of Keap1: Nrf1, but not Nrf2, is targeted to the endoplasmic reticulumKeap1 controls postinduction repression of the Nrf2-mediated antioxidant response by escorting nuclear export of Nrf2Regulation of PKM2 and Nrf2-ARE pathway during benzoquinone induced oxidative stress in yolk sac hematopoietic stem cellsCellular stress responses, the hormesis paradigm, and vitagenes: novel targets for therapeutic intervention in neurodegenerative disordersPGAM5 tethers a ternary complex containing Keap1 and Nrf2 to mitochondriaStress-activated cap'n'collar transcription factors in aging and human diseaseCACUL1/CAC1 Regulates the Antioxidant Response by Stabilizing Nrf2Small molecule modulators of Keap1-Nrf2-ARE pathway as potential preventive and therapeutic agentsArsenic-mediated activation of the Nrf2-Keap1 antioxidant pathwayThe complexity of the Nrf2 pathway: beyond the antioxidant responseEffect of Nrf2 on rat ovarian tissues against atrazine-induced anti-oxidative responseBasic principles and emerging concepts in the redox control of transcription factorsUnique pattern of component gene disruption in the NRF2 inhibitor KEAP1/CUL3/RBX1 E3-ubiquitin ligase complex in serous ovarian cancer
P2860
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P2860
Keap1 recruits Neh2 through binding to ETGE and DLG motifs: characterization of the two-site molecular recognition model
description
2006 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2006
@ast
im April 2006 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
wetenschappelijk artikel (gepubliceerd op 2006/04/01)
@nl
наукова стаття, опублікована у квітні 2006
@uk
مقالة علمية (نشرت في أبريل 2006)
@ar
name
Keap1 recruits Neh2 through bi ...... te molecular recognition model
@ast
Keap1 recruits Neh2 through bi ...... te molecular recognition model
@en
type
label
Keap1 recruits Neh2 through bi ...... te molecular recognition model
@ast
Keap1 recruits Neh2 through bi ...... te molecular recognition model
@en
prefLabel
Keap1 recruits Neh2 through bi ...... te molecular recognition model
@ast
Keap1 recruits Neh2 through bi ...... te molecular recognition model
@en
P2093
P2860
P3181
P1476
Keap1 recruits Neh2 through bi ...... te molecular recognition model
@en
P2093
Hideki Kusunoki
Kit I. Tong
Masayuki Yamamoto
Toshiyuki Tanaka
Yasutake Katoh
P2860
P304
P3181
P356
10.1128/MCB.26.8.2887-2900.2006
P407
P577
2006-04-01T00:00:00Z