Surface comparison of active and inactive protein kinases identifies a conserved activation mechanism - Wikidata - wikimedia - TriplyDB

Surface comparison of active and inactive protein kinases identifies a conserved activation mechanism

Surface comparison of active and inactive protein kinases identifies a conserved activation mechanism

http://www.wikidata.org/entity/Q29616720

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Crystal structure of the Golgi casein kinase Structural bases of PAS domain-regulated kinase (PASK) activation in the absence of activation loop phosphorylation Mitochondrial ADCK3 employs an atypical protein kinase-like fold to enable coenzyme Q biosynthesis Insights into the evolution of divergent nucleotide-binding mechanisms among pseudokinases revealed by crystal structures of human and mouse MLKL Discovery of a novel mode of protein kinase inhibition characterized by the mechanism of inhibition of human mesenchymal-epithelial transition factor (c-Met) protein autophosphorylation by ARQ 197 A conserved protonation-dependent switch controls drug binding in the Abl kinase Biallelic Mutations in Citron Kinase Link Mitotic Cytokinesis to Human Primary Microcephaly Charting a Path to Success in Virtual Screening Abscisic acid perception and signaling: structural mechanisms and applications PKA: lessons learned after twenty years Ten things you should know about protein kinases: IUPHAR Review 14 Assembly of allosteric macromolecular switches: lessons from PKA Design principles underpinning the regulatory diversity of protein kinases Structure and mechanism of action of the hydroxy–aryl–aldehyde class of IRE1 endoribonuclease inhibitors Cerebellar Ataxia and Coenzyme Q Deficiency through Loss of Unorthodox Kinase Activity Activation of tyrosine kinases by mutation of the gatekeeper threonine Insights into the Conformational Variability and Regulation of Human Nek2 Kinase Structure of the Pseudokinase VRK3 Reveals a Degraded Catalytic Site, a Highly Conserved Kinase Fold, and a Putative Regulatory Binding Site Crystal structure of domain-swapped STE20 OSR1 kinase domain Comparative surface geometry of the protein kinase family Novel Isoform-Specific Interfaces Revealed by PKA RIIβ Holoenzyme Structures An Autoinhibitory Tyrosine Motif in the Cell-Cycle-Regulated Nek7 Kinase Is Released through Binding of Nek9 Crystal structure of an Aurora-A mutant that mimics Aurora-B bound to MLN8054: insights into selectivity and drug design The p110δ structure: mechanisms for selectivity and potency of new PI(3)K inhibitors Aminopyrazine Inhibitors Binding to an Unusual Inactive Conformation of the Mitotic Kinase Nek2: SAR and Structural Characterization A Novel Mode of Protein Kinase Inhibition Exploiting Hydrophobic Motifs of Autoinhibited Kinases: DISCOVERY OF ATP-INDEPENDENT INHIBITORS OF FIBROBLAST GROWTH FACTOR RECEPTOR Conformational Control Inhibition of the BCR-ABL1 Tyrosine Kinase, Including the Gatekeeper T315I Mutant, by the Switch-Control Inhibitor DCC-2036 Briefly Bound to Activate: Transient Binding of a Second Catalytic Magnesium Activates the Structure and Dynamics of CDK2 Kinase for Catalysis Fluorophore Labeled Kinase Detects Ligands That Bind within the MAPK Insert of p38α Kinase Flexibility of the P-loop of Pim-1 kinase: observation of a novel conformation induced by interaction with an inhibitor Chemical genetic strategy for targeting protein kinases based on covalent complementarity Affinity-Based Probes Based on Type II Kinase Inhibitors Structural basis for basal activity and autoactivation of abscisic acid (ABA) signaling SnRK2 kinases Structural Basis for the Regulation of Protein Kinase A by Activation Loop Phosphorylation Structural basis for the altered drug sensitivities of non-small cell lung cancer-associated mutants of human epidermal growth factor receptor Structure-kinetic relationship study of CDK8/CycC specific compounds Inhibitors that stabilize a closed RAF kinase domain conformation induce dimerization Sequence Determinants of a Specific Inactive Protein Kinase Conformation Role of N-Terminal Myristylation in the Structure and Regulation of cAMP-Dependent Protein Kinase Structural Basis for the Regulation of Maternal Embryonic Leucine Zipper Kinase

P2860

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P2860

Surface comparison of active and inactive protein kinases identifies a conserved activation mechanism

http://www.wikidata.org/entity/Q29616720

description

2006 nî lūn-bûn

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2006 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

@hyw

2006 թվականի նոյեմբերին հրատարակված գիտական հոդված

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2006年の論文

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2006年論文

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2006年論文

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2006年論文

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2006年論文

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2006年論文

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2006年论文

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Surface comparison of active a ...... conserved activation mechanism

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Surface comparison of active a ...... conserved activation mechanism

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Surface comparison of active a ...... conserved activation mechanism

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Surface comparison of active a ...... conserved activation mechanism

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Surface comparison of active a ...... conserved activation mechanism

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Proceedings of the National Academy of Sciences of the United States of America

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Surface comparison of active a ...... conserved activation mechanism

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P2093

Lynn F Ten Eyck

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Nina M Haste

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Susan S Taylor

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P2860

Crystal structures of c-Src reveal features of its autoinhibitory mechanism

Structure and regulation of the CDK5-p25(nck5a) complex

Inhibition of p38 MAP kinase by utilizing a novel allosteric binding site

Structural basis for the autoinhibition of c-Abl tyrosine kinase

Crystal structure of the catalytic subunit of cyclic adenosine monophosphate-dependent protein kinase

Multiple modes of ligand recognition: crystal structures of cyclin-dependent protein kinase 2 in complex with ATP and two inhibitors, olomoucine and isopentenyladenine

Mechanism of CDK activation revealed by the structure of a cyclinA-CDK2 complex

Crystal structure of the tyrosine kinase domain of the human insulin receptor

Structural basis for activation of human lymphocyte kinase Lck upon tyrosine phosphorylation

Activation mechanism of the MAP kinase ERK2 by dual phosphorylation

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