Lrp4, a novel receptor for Dickkopf 1 and sclerostin, is expressed by osteoblasts and regulates bone growth and turnover in vivo. - Wikidata - wikimedia - TriplyDB

Lrp4, a novel receptor for Dickkopf 1 and sclerostin, is expressed by osteoblasts and regulates bone growth and turnover in vivo.

Lrp4, a novel receptor for Dickkopf 1 and sclerostin, is expressed by osteoblasts and regulates bone growth and turnover in vivo.

http://www.wikidata.org/entity/Q30914003

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Bone overgrowth-associated mutations in the LRP4 gene impair sclerostin facilitator function LRP4 mutations alter Wnt/beta-catenin signaling and cause limb and kidney malformations in Cenani-Lenz syndrome Effects of PTH on osteocyte function WNT signaling in bone development and homeostasis The osteocyte as a therapeutic target in the treatment of osteoporosis The DAN family: modulators of TGF-β signaling and beyond Anti-LRP4 autoantibodies in AChR- and MuSK-antibody-negative myasthenia gravis Agrin binds to the N-terminal region of Lrp4 protein and stimulates association between Lrp4 and the first immunoglobulin-like domain in muscle-specific kinase (MuSK)Mutational analysis of sclerostin shows importance of the flexible loop and the cystine-knot for Wnt-signaling inhibition Mesdc2 plays a key role in cell-surface expression of Lrp4 and postsynaptic specialization in myotubes Ectodomains of the LDL receptor-related proteins LRP1b and LRP4 have anchorage independent functions in vivo LRP4 third β-propeller domain mutations cause novel congenital myasthenia by compromising agrin-mediated MuSK signaling in a position-specific manner.Sclerostin stimulates osteocyte support of osteoclast activity by a RANKL-dependent pathway Lrp4 regulates initiation of ureteric budding and is crucial for kidney formation--a mouse model for Cenani-Lenz syndrome Suppression of Sclerostin Alleviates Radiation-Induced Bone Loss by Protecting Bone-Forming Cells and Their Progenitors Through Distinct Mechanisms.Mesd is a universal inhibitor of Wnt coreceptors LRP5 and LRP6 and blocks Wnt/beta-catenin signaling in cancer cells.T cells: critical bone regulators in health and disease.The immune system and bone.SOST and DKK: Antagonists of LRP Family Signaling as Targets for Treating Bone Disease.Deletion of a single β-catenin allele in osteocytes abolishes the bone anabolic response to loading LRP4 is critical for neuromuscular junction maintenance Consequences of daily administered parathyroid hormone on myeloma growth, bone disease, and molecular profiling of whole myelomatous bone.Receptor heterodimerization as a novel mechanism for the regulation of Wnt/β-catenin signaling.An RNA-seq protocol to identify mRNA expression changes in mouse diaphyseal bone: applications in mice with bone property altering Lrp5 mutations Wnt signaling and the control of human stem cell fate.An Akt-dependent increase in canonical Wnt signaling and a decrease in sclerostin protein levels are involved in strontium ranelate-induced osteogenic effects in human osteoblasts.Anabolic and catabolic regimens of human parathyroid hormone 1-34 elicit bone- and envelope-specific attenuation of skeletal effects in Sost-deficient mice.Lrp4 in osteoblasts suppresses bone formation and promotes osteoclastogenesis and bone resorption PTH receptor signaling in osteocytes governs periosteal bone formation and intracortical remodeling.Relevance of Wnt signaling for osteoanabolic therapy.TGF-β regulates sclerostin expression via the ECR5 enhancer.A Comprehensive Overview of Skeletal Phenotypes Associated with Alterations in Wnt/β-catenin Signaling in Humans and Mice.Common genetic variation in the 3'-BCL11B gene desert is associated with carotid-femoral pulse wave velocity and excess cardiovascular disease risk: the AortaGen Consortium.The regulation of osteoclast differentiation by Wnt signals Missense Mutations in LRP5 Associated with High Bone Mass Protect the Mouse Skeleton from Disuse- and Ovariectomy-Induced Osteopenia.Sclerostin is a locally acting regulator of late-osteoblast/preosteocyte differentiation and regulates mineralization through a MEPE-ASARM-dependent mechanism.LRP receptor family member associated bone disease Absence of sclerostin adversely affects B-cell survival.Beta-Catenin Haplo Insufficient Male Mice Do Not Lose Bone in Response to Hindlimb Unloading.Update on Wnt signaling in bone cell biology and bone disease.

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P2860

Lrp4, a novel receptor for Dickkopf 1 and sclerostin, is expressed by osteoblasts and regulates bone growth and turnover in vivo.

http://www.wikidata.org/entity/Q30914003

description

2009 nî lūn-bûn

@nan

2009 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

@hyw

2009 թվականի նոյեմբերին հրատարակված գիտական հոդված

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2009年の論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年论文

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name

Lrp4, a novel receptor for Dic ...... e growth and turnover in vivo.

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Lrp4, a novel receptor for Dic ...... e growth and turnover in vivo.

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type

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Lrp4, a novel receptor for Dic ...... e growth and turnover in vivo.

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Lrp4, a novel receptor for Dic ...... e growth and turnover in vivo.

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Lrp4, a novel receptor for Dic ...... e growth and turnover in vivo.

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Lrp4, a novel receptor for Dic ...... e growth and turnover in vivo.

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JOURNAL.PONE.0007930

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Lrp4, a novel receptor for Dic ...... e growth and turnover in vivo.

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Andreas Niemeier

http://www.w3.org/2001/XMLSchema#string

Hong Y Choi

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Joachim Herz

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Marco Dieckmann

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P2860

LRP1 functions as an atheroprotective integrator of TGFbeta and PDFG signals in the vascular wall: implications for Marfan syndrome

Endocrine regulation of energy metabolism by the skeleton

Increased bone density in sclerosteosis is due to the deficiency of a novel secreted protein (SOST)

Novel mechanism of Wnt signalling inhibition mediated by Dickkopf-1 interaction with LRP6/Arrow

Osteocyte control of bone formation via sclerostin, a novel BMP antagonist

Polymorphisms in the sclerosteosis/van Buchem disease gene (SOST) region are associated with bone-mineral density in elderly whites.

Bone dysplasia sclerosteosis results from loss of the SOST gene product, a novel cystine knot-containing protein

Identification of a 52 kb deletion downstream of the SOST gene in patients with van Buchem disease

LDL-receptor-related protein 6 is a receptor for Dickkopf proteins

Kremen proteins are Dickkopf receptors that regulate Wnt/beta-catenin signalling

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