Discovery and SAR of novel mGluR5 non-competitive antagonists not based on an MPEP chemotype.
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Substituted 1-Phenyl-3-(pyridin-2-yl)urea negative allosteric modulators of mGlu5: discovery of a new tool compound VU0463841 with activity in rat models of cocaine addiction.N-Acyl-N'-arylpiperazines as negative allosteric modulators of mGlu1: identification of VU0469650, a potent and selective tool compound with CNS exposure in rats.Targeting glutamate synapses in schizophrenia(3-Cyano-5-fluorophenyl)biaryl negative allosteric modulators of mGlu(5): Discovery of a new tool compound with activity in the OSS mouse model of addiction3-Cyano-5-fluoro-N-arylbenzamides as negative allosteric modulators of mGlu(5): Identification of easily prepared tool compounds with CNS exposure in rats.Recent advances in the design and development of novel negative allosteric modulators of mGlu(5)Progress toward positive allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5).Investigating metabotropic glutamate receptor 5 allosteric modulator cooperativity, affinity, and agonism: enriching structure-function studies and structure-activity relationships.Probing the metabotropic glutamate receptor 5 (mGlu₅) positive allosteric modulator (PAM) binding pocket: discovery of point mutations that engender a "molecular switch" in PAM pharmacology."Molecular switches" on mGluR allosteric ligands that modulate modes of pharmacology.Synthesis and SAR of novel, non-MPEP chemotype mGluR5 NAMs identified by functional HTSDiscovery of molecular switches within the ADX-47273 mGlu5 PAM scaffold that modulate modes of pharmacology to afford potent mGlu5 NAMs, PAMs and partial antagonists.Discovery and SAR of 6-substituted-4-anilinoquinazolines as non-competitive antagonists of mGlu5.Octahydropyrrolo[3,4-c]pyrrole negative allosteric modulators of mGlu1.Discovery of VU0409106: A negative allosteric modulator of mGlu5 with activity in a mouse model of anxietyDiscovery of N-Aryl Piperazines as Selective mGlu(5) Potentiators with Efficacy in a Rodent Model Predictive of Anti-Psychotic Activity.Discovery of VU0431316: a negative allosteric modulator of mGlu5 with activity in a mouse model of anxiety.
P2860
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P2860
Discovery and SAR of novel mGluR5 non-competitive antagonists not based on an MPEP chemotype.
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
2009年论文
@zh
2009年论文
@zh-cn
name
Discovery and SAR of novel mGl ...... ot based on an MPEP chemotype.
@en
type
label
Discovery and SAR of novel mGl ...... ot based on an MPEP chemotype.
@en
prefLabel
Discovery and SAR of novel mGl ...... ot based on an MPEP chemotype.
@en
P2093
P2860
P1476
Discovery and SAR of novel mGl ...... ot based on an MPEP chemotype.
@en
P2093
Alice L Rodriguez
C David Weaver
Mark D Grier
Richard Williams
Stacey R Lindsley
P2860
P304
P356
10.1016/J.BMCL.2009.04.110
P407
P577
2009-05-03T00:00:00Z