Synthesis and SAR of centrally active mGlu5 positive allosteric modulators based on an aryl acetylenic bicyclic lactam scaffold.
about
Unique signaling profiles of positive allosteric modulators of metabotropic glutamate receptor subtype 5 determine differences in in vivo activity.Tetrahydronaphthyridine and dihydronaphthyridinone ethers as positive allosteric modulators of the metabotropic glutamate receptor 5 (mGlu₅).Relationship between in vivo receptor occupancy and efficacy of metabotropic glutamate receptor subtype 5 allosteric modulators with different in vitro binding profilesHead-to head comparison of mGlu1 and mGlu5 receptor activation in chronic treatment of absence epilepsy in WAG/Rij rats.Functional impact of allosteric agonist activity of selective positive allosteric modulators of metabotropic glutamate receptor subtype 5 in regulating central nervous system function.Progress toward positive allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5).Biotransformation of a novel positive allosteric modulator of metabotropic glutamate receptor subtype 5 contributes to seizure-like adverse events in rats involving a receptor agonism-dependent mechanism.Metabotropic glutamate receptors as therapeutic targets for schizophrenia.Metabotropic glutamate receptor 5-positive allosteric modulators for the treatment of schizophrenia (2004-2012).Drug Design Strategies for GPCR Allosteric Modulators.Development of a novel, CNS-penetrant, metabotropic glutamate receptor 3 (mGlu3) NAM probe (ML289) derived from a closely related mGlu5 PAM.Anti-absence activity of mGlu1 and mGlu5 receptor enhancers and their interaction with a GABA reuptake inhibitor: Effect of local infusions in the somatosensory cortex and thalamus.Discovery of VU0409551/JNJ-46778212: An mGlu5 Positive Allosteric Modulator Clinical Candidate Targeting Schizophrenia.Optimization of an ether series of mGlu5 positive allosteric modulators: molecular determinants of MPEP-site interaction crossover.
P2860
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P2860
Synthesis and SAR of centrally active mGlu5 positive allosteric modulators based on an aryl acetylenic bicyclic lactam scaffold.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
Synthesis and SAR of centrally ...... enic bicyclic lactam scaffold.
@en
type
label
Synthesis and SAR of centrally ...... enic bicyclic lactam scaffold.
@en
prefLabel
Synthesis and SAR of centrally ...... enic bicyclic lactam scaffold.
@en
P2093
P2860
P50
P1476
Synthesis and SAR of centrally ...... enic bicyclic lactam scaffold.
@en
P2093
Alice L Rodriguez
C David Weaver
Carrie K Jones
Jason T Manka
Paige N Vinson
Richard Williams
Shaun R Stauffer
P2860
P304
P356
10.1016/J.BMCL.2011.01.044
P407
P577
2011-01-18T00:00:00Z