The AID antibody diversification enzyme is regulated by protein kinase A phosphorylation.
about
AID and APOBECs span the gap between innate and adaptive immunityHistone chaperone Spt6 is required for class switch recombination but not somatic hypermutationThe RNA exosome targets the AID cytidine deaminase to both strands of transcribed duplex DNA substratesRegulation of aicda expression and AID activity: relevance to somatic hypermutation and class switch DNA recombinationMicroRNA-155 suppresses activation-induced cytidine deaminase-mediated Myc-Igh translocationMicroRNA-155 is a negative regulator of activation-induced cytidine deaminaseMutations, kataegis and translocations in B cells: understanding AID promiscuous activityMultiple APOBEC3 restriction factors for HIV-1 and one Vif to rule them allRegulation of Aicda expression and AID activityTranscriptional stalling in B-lymphocytes: a mechanism for antibody diversification and maintenance of genomic integrityRelated Mechanisms of Antibody Somatic Hypermutation and Class Switch RecombinationAID/APOBEC deaminases and cancerFirst AID (activation-induced cytidine deaminase) is needed to produce high affinity isotype-switched antibodiesThe splicing regulator PTBP2 interacts with the cytidine deaminase AID and promotes binding of AID to switch-region DNAThe interaction between AID and CIB1 is nonessential for antibody gene diversification by gene conversion or class switch recombinationTemporal regulation of Ig gene diversification revealed by single-cell imaging.Integrity of the AID serine-38 phosphorylation site is critical for class switch recombination and somatic hypermutation in miceActivation-induced deaminase, AID, is catalytically active as a monomer on single-stranded DNA.Impact of phosphorylation and phosphorylation-null mutants on the activity and deamination specificity of activation-induced cytidine deaminase.Evolution of phosphorylation-dependent regulation of activation-induced cytidine deaminase.Antibodies to the desmoglein 1 precursor proprotein but not to the mature cell surface protein cloned from individuals without pemphigus.Two forms of activation-induced cytidine deaminase differing in their ability to bind agarose.A coming-of-age story: activation-induced cytidine deaminase turns 10.Generation and repair of AID-initiated DNA lesions in B lymphocytes.Deep-sequencing identification of the genomic targets of the cytidine deaminase AID and its cofactor RPA in B lymphocytesMutations in human AID differentially affect its ability to deaminate cytidine and 5-methylcytidine in ssDNA substrates in vitroBinding of AID to DNA does not correlate with mutator activity.Recombinant retroviral production and infection of B cells.Induction of homologous recombination between sequence repeats by the activation induced cytidine deaminase (AID) proteinGANP-mediated recruitment of activation-induced cytidine deaminase to cell nuclei and to immunoglobulin variable region DNA.Replication protein A (RPA) hampers the processive action of APOBEC3G cytosine deaminase on single-stranded DNAClustered and genome-wide transient mutagenesis in human cancers: Hypermutation without permanent mutators or loss of fitnessRegulation of immunoglobulin class-switch recombination: choreography of noncoding transcription, targeted DNA deamination, and long-range DNA repair.AID and somatic hypermutation.Lysine residue at position 22 of the AID protein regulates its class switch activity.Specific recruitment of protein kinase A to the immunoglobulin locus regulates class-switch recombination.PKA-mediated phosphorylation regulates the function of activation-induced deaminase (AID) in B cellsActivation-induced cytidine deaminase targets DNA at sites of RNA polymerase II stalling by interaction with Spt5MEF2B mutations lead to deregulated expression of the oncogene BCL6 in diffuse large B cell lymphoma.Cyclin D3 is selectively required for proliferative expansion of germinal center B cells.
P2860
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P2860
The AID antibody diversification enzyme is regulated by protein kinase A phosphorylation.
description
2005 nî lūn-bûn
@nan
2005 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
The AID antibody diversification enzyme is regulated by protein kinase A phosphorylation.
@ast
The AID antibody diversification enzyme is regulated by protein kinase A phosphorylation.
@en
type
label
The AID antibody diversification enzyme is regulated by protein kinase A phosphorylation.
@ast
The AID antibody diversification enzyme is regulated by protein kinase A phosphorylation.
@en
prefLabel
The AID antibody diversification enzyme is regulated by protein kinase A phosphorylation.
@ast
The AID antibody diversification enzyme is regulated by protein kinase A phosphorylation.
@en
P2093
P2860
P356
P1433
P1476
The AID antibody diversification enzyme is regulated by protein kinase A phosphorylation.
@en
P2093
Craig Alpert
Frederick W Alt
Jason Patrick Schrum
Jayanta Chaudhuri
John P Manis
Sheila Ranganath
Shilpee Dutt
Uttiya Basu
P2860
P2888
P304
P356
10.1038/NATURE04255
P407
P577
2005-10-26T00:00:00Z
P5875
P6179
1020929525