The AID antibody diversification enzyme is regulated by protein kinase A phosphorylation. - Wikidata - wikimedia - TriplyDB

The AID antibody diversification enzyme is regulated by protein kinase A phosphorylation.

The AID antibody diversification enzyme is regulated by protein kinase A phosphorylation.

http://www.wikidata.org/entity/Q33226024

about

AID and APOBECs span the gap between innate and adaptive immunity Histone chaperone Spt6 is required for class switch recombination but not somatic hypermutation The RNA exosome targets the AID cytidine deaminase to both strands of transcribed duplex DNA substrates Regulation of aicda expression and AID activity: relevance to somatic hypermutation and class switch DNA recombination MicroRNA-155 suppresses activation-induced cytidine deaminase-mediated Myc-Igh translocation MicroRNA-155 is a negative regulator of activation-induced cytidine deaminase Mutations, kataegis and translocations in B cells: understanding AID promiscuous activity Multiple APOBEC3 restriction factors for HIV-1 and one Vif to rule them all Regulation of Aicda expression and AID activity Transcriptional stalling in B-lymphocytes: a mechanism for antibody diversification and maintenance of genomic integrity Related Mechanisms of Antibody Somatic Hypermutation and Class Switch Recombination AID/APOBEC deaminases and cancer First AID (activation-induced cytidine deaminase) is needed to produce high affinity isotype-switched antibodies The splicing regulator PTBP2 interacts with the cytidine deaminase AID and promotes binding of AID to switch-region DNA The interaction between AID and CIB1 is nonessential for antibody gene diversification by gene conversion or class switch recombination Temporal regulation of Ig gene diversification revealed by single-cell imaging.Integrity of the AID serine-38 phosphorylation site is critical for class switch recombination and somatic hypermutation in mice Activation-induced deaminase, AID, is catalytically active as a monomer on single-stranded DNA.Impact of phosphorylation and phosphorylation-null mutants on the activity and deamination specificity of activation-induced cytidine deaminase.Evolution of phosphorylation-dependent regulation of activation-induced cytidine deaminase.Antibodies to the desmoglein 1 precursor proprotein but not to the mature cell surface protein cloned from individuals without pemphigus.Two forms of activation-induced cytidine deaminase differing in their ability to bind agarose.A coming-of-age story: activation-induced cytidine deaminase turns 10.Generation and repair of AID-initiated DNA lesions in B lymphocytes.Deep-sequencing identification of the genomic targets of the cytidine deaminase AID and its cofactor RPA in B lymphocytes Mutations in human AID differentially affect its ability to deaminate cytidine and 5-methylcytidine in ssDNA substrates in vitro Binding of AID to DNA does not correlate with mutator activity.Recombinant retroviral production and infection of B cells.Induction of homologous recombination between sequence repeats by the activation induced cytidine deaminase (AID) protein GANP-mediated recruitment of activation-induced cytidine deaminase to cell nuclei and to immunoglobulin variable region DNA.Replication protein A (RPA) hampers the processive action of APOBEC3G cytosine deaminase on single-stranded DNA Clustered and genome-wide transient mutagenesis in human cancers: Hypermutation without permanent mutators or loss of fitness Regulation of immunoglobulin class-switch recombination: choreography of noncoding transcription, targeted DNA deamination, and long-range DNA repair.AID and somatic hypermutation.Lysine residue at position 22 of the AID protein regulates its class switch activity.Specific recruitment of protein kinase A to the immunoglobulin locus regulates class-switch recombination.PKA-mediated phosphorylation regulates the function of activation-induced deaminase (AID) in B cells Activation-induced cytidine deaminase targets DNA at sites of RNA polymerase II stalling by interaction with Spt5 MEF2B mutations lead to deregulated expression of the oncogene BCL6 in diffuse large B cell lymphoma.Cyclin D3 is selectively required for proliferative expansion of germinal center B cells.

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The AID antibody diversification enzyme is regulated by protein kinase A phosphorylation.

http://www.wikidata.org/entity/Q33226024

description

2005 nî lūn-bûn

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2005 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2005 թվականի հոտեմբերին հրատարակված գիտական հոդված

@hy

2005年の論文

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2005年論文

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2005年論文

@zh-hant

2005年論文

@zh-hk

2005年論文

@zh-mo

2005年論文

@zh-tw

2005年论文

@wuu

name

The AID antibody diversification enzyme is regulated by protein kinase A phosphorylation.

@ast

The AID antibody diversification enzyme is regulated by protein kinase A phosphorylation.

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type

label

The AID antibody diversification enzyme is regulated by protein kinase A phosphorylation.

@ast

The AID antibody diversification enzyme is regulated by protein kinase A phosphorylation.

@en

prefLabel

The AID antibody diversification enzyme is regulated by protein kinase A phosphorylation.

@ast

The AID antibody diversification enzyme is regulated by protein kinase A phosphorylation.

@en

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The AID antibody diversification enzyme is regulated by protein kinase A phosphorylation.

@en

P2093

Craig Alpert

http://www.w3.org/2001/XMLSchema#string

Frederick W Alt

http://www.w3.org/2001/XMLSchema#string

Gang Li

http://www.w3.org/2001/XMLSchema#string

Jason Patrick Schrum

http://www.w3.org/2001/XMLSchema#string

Jayanta Chaudhuri

http://www.w3.org/2001/XMLSchema#string

John P Manis

http://www.w3.org/2001/XMLSchema#string

Sheila Ranganath

http://www.w3.org/2001/XMLSchema#string

Shilpee Dutt

http://www.w3.org/2001/XMLSchema#string

Uttiya Basu

http://www.w3.org/2001/XMLSchema#string

P2860

Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2)

Activation-induced cytidine deaminase deaminates deoxycytidine on single-stranded DNA but requires the action of RNase

Transcription enhances AID-mediated cytidine deamination by exposing single-stranded DNA on the nontemplate strand

Transcription-targeted DNA deamination by the AID antibody diversification enzyme

AID mutates E. coli suggesting a DNA deamination mechanism for antibody diversification

Replication protein A: a heterotrimeric, single-stranded DNA-binding protein required for eukaryotic DNA metabolism

Class-switch recombination: interplay of transcription, DNA deamination and DNA repair

Specific expression of activation-induced cytidine deaminase (AID), a novel member of the RNA-editing deaminase family in germinal center B cells

Mismatch recognition and uracil excision provide complementary paths to both Ig switching and the A/T-focused phase of somatic mutation

Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme

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508-511

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10.1038/NATURE04255

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7067

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438

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2005-10-26T00:00:00Z

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7514697

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1020929525

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16251902

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phosphorylation