The SIRT1 deacetylase suppresses intestinal tumorigenesis and colon cancer growth
about
Sirtuins: molecular traffic lights in the crossroad of oxidative stress, chromatin remodeling, and transcriptionMCC inhibits beta-catenin transcriptional activity by sequestering DBC1 in the cytoplasmThe histone deacetylase SIRT6 is a tumor suppressor that controls cancer metabolismSIRT1 promotes N-Myc oncogenesis through a positive feedback loop involving the effects of MKP3 and ERK on N-Myc protein stabilityInhibition of SUV39H1 methyltransferase activity by DBC1CK2 is the regulator of SIRT1 substrate-binding affinity, deacetylase activity and cellular response to DNA-damageCrystal structures of human SIRT3 displaying substrate-induced conformational changesSir-two-homolog 2 (Sirt2) modulates peripheral myelination through polarity protein Par-3/atypical protein kinase C (aPKC) signalingSIRT1 redistribution on chromatin promotes genomic stability but alters gene expression during agingSIRT1 suppresses beta-amyloid production by activating the alpha-secretase gene ADAM10.Biochemical effects of SIRT1 activatorsPCAF acetylates {beta}-catenin and improves its stabilityPtk7 and Mcc, Unfancied Components in Non-Canonical Wnt Signaling and CancerBiochemical Genetic Pathways that Modulate Aging in Multiple SpeciesBioactive Compounds Isolated from Microalgae in Chronic Inflammation and CancerSirtuin 1 and sirtuin 3: physiological modulators of metabolismPleiotropic cellular functions of PARP1 in longevity and aging: genome maintenance meets inflammationT cell replicative senescence in human agingSirtuins in epigenetic regulationImpacts on Sirtuin Function and Bioavailability of the Dietary Bioactive Compound DihydrocoumarinModulation of tumorigenesis by dietary intervention is not mediated by SIRT1 catalytic activityHigh SIRT1 expression is a negative prognosticator in pancreatic ductal adenocarcinomaCircadian clocks and breast cancerp53 as a Regulator of Lipid Metabolism in CancerSIRT2 interacts with β-catenin to inhibit Wnt signaling output in response to radiation-induced stressEvidence for a common mechanism of SIRT1 regulation by allosteric activatorsIntegration of β-catenin, sirtuin, and FOXO signaling protects from mutant huntingtin toxicityBiochemical characterization, localization, and tissue distribution of the longer form of mouse SIRT3Emerging Roles of SIRT1 in Cancer Drug ResistanceDisruption of a Sirt1-dependent autophagy checkpoint in the prostate results in prostatic intraepithelial neoplasia lesion formationSynthesis and Assay of SIRT1-Activating CompoundsMammalian sirtuins: biological insights and disease relevanceRecent progress in the biology and physiology of sirtuinsEnergy sensing pathways: Bridging type 2 diabetes and colorectal cancer?SIRT1 is essential for normal cognitive function and synaptic plasticityRejuvenating sirtuins: the rise of a new family of cancer drug targetsEnterocyte-specific inactivation of SIRT1 reduces tumor load in the APC(+/min) mouse model.Comprehensive biostatistical analysis of CpG island methylator phenotype in colorectal cancer using a large population-based sampleOncogenic viral protein HPV E7 up-regulates the SIRT1 longevity protein in human cervical cancer cellsSmall-molecule allosteric activators of sirtuins.
P2860
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P2860
The SIRT1 deacetylase suppresses intestinal tumorigenesis and colon cancer growth
description
2008 nî lūn-bûn
@nan
2008 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
The SIRT1 deacetylase suppresses intestinal tumorigenesis and colon cancer growth
@ast
The SIRT1 deacetylase suppresses intestinal tumorigenesis and colon cancer growth
@en
The SIRT1 deacetylase suppresses intestinal tumorigenesis and colon cancer growth.
@nl
type
label
The SIRT1 deacetylase suppresses intestinal tumorigenesis and colon cancer growth
@ast
The SIRT1 deacetylase suppresses intestinal tumorigenesis and colon cancer growth
@en
The SIRT1 deacetylase suppresses intestinal tumorigenesis and colon cancer growth.
@nl
prefLabel
The SIRT1 deacetylase suppresses intestinal tumorigenesis and colon cancer growth
@ast
The SIRT1 deacetylase suppresses intestinal tumorigenesis and colon cancer growth
@en
The SIRT1 deacetylase suppresses intestinal tumorigenesis and colon cancer growth.
@nl
P2093
P2860
P50
P1433
P1476
The SIRT1 deacetylase suppresses intestinal tumorigenesis and colon cancer growth
@en
P2093
Anupama Bhimavarapu
Gil Blander
Jennifer Campbell
Leonard P Guarente
Philipp Oberdoerffer
Ron Firestein
Sandra Luikenhuis
Shaday Michan
William C Hahn
P2860
P356
10.1371/JOURNAL.PONE.0002020
P407
P577
2008-04-16T00:00:00Z