The OTT-MAL fusion oncogene activates RBPJ-mediated transcription and induces acute megakaryoblastic leukemia in a knockin mouse model. - Wikidata - wikimedia - TriplyDB

The OTT-MAL fusion oncogene activates RBPJ-mediated transcription and induces acute megakaryoblastic leukemia in a knockin mouse model.

The OTT-MAL fusion oncogene activates RBPJ-mediated transcription and induces acute megakaryoblastic leukemia in a knockin mouse model.

http://www.wikidata.org/entity/Q33383707

about

Megakaryocyte pathology and bone marrow fibrosis: the lysyl oxidase connection The aryl hydrocarbon receptor (AHR) transcription factor regulates megakaryocytic polyploidization Genomic landscape of megakaryopoiesis and platelet function defects The biology of pediatric acute megakaryoblastic leukemia Epigenetic Guardian: A Review of the DNA Methyltransferase DNMT3A in Acute Myeloid Leukaemia and Clonal Haematopoiesis.Role of RhoA-specific guanine exchange factors in regulation of endomitosis in megakaryocytes.Leukaemogenesis induced by an activating β-catenin mutation in osteoblasts.Linking actin dynamics and gene transcription to drive cellular motile functions.The aurora kinases in cell cycle and leukemia Identification of regulators of polyploidization presents therapeutic targets for treatment of AMKL Notch signalling in T-cell lymphoblastic leukaemia/lymphoma and other haematological malignancies.Rbm15-Mkl1 interacts with the Setd1b histone H3-Lys4 methyltransferase via a SPOC domain that is required for cytokine-independent proliferation.Ott1 (Rbm15) regulates thrombopoietin response in hematopoietic stem cells through alternative splicing of c-Mpl Crosstalk between NOTCH and AKT signaling during murine megakaryocyte lineage specification Hematopoietic stem cells lacking Ott1 display aspects associated with aging and are unable to maintain quiescence during proliferative stress.spenito is required for sex determination in Drosophila melanogaster Characterization of novel genomic alterations and therapeutic approaches using acute megakaryoblastic leukemia xenograft models.Ikaros inhibits megakaryopoiesis through functional interaction with GATA-1 and NOTCH signaling Baicalein antagonizes acute megakaryoblastic leukemia in vitro and in vivo by inducing cell cycle arrest Normal and malignant megakaryopoiesis.Tyrosine 625 plays a key role and cooperates with tyrosine 630 in MPL W515L-induced signaling and myeloproliferative neoplasms.Depletion of the transcriptional coactivators megakaryoblastic leukaemia 1 and 2 abolishes hepatocellular carcinoma xenograft growth by inducing oncogene-induced senescence.Acute Myeloid Leukemia With RBM15-MKL1 Presenting as Severe Hepatic Failure.Bone's dark side: mutated osteoblasts implicated in leukemia.Whole-exome sequencing identifies a novel somatic mutation in MMP8 associated with a t(1;22)-acute megakaryoblastic leukemia.Notch signaling: switching an oncogene to a tumor suppressor.Acute Megakaryoblastic Leukemia with t(1;22) Mimicking Neuroblastoma in an Infant.BMP meets AML: induction of BMP signaling by a novel fusion gene promotes pediatric acute leukemia.Downregulation of GATA1 drives impaired hematopoiesis in primary myelofibrosis.Canonical Notch signaling is dispensible for adult steady-state and stress myelo-erythropoiesis.Tetrandrine antagonizes acute megakaryoblastic leukaemia growth by forcing autophagy-mediated differentiation.PRMT1-RBM15 axis regulates megakaryocytic differentiation of human umbilical cord blood CD34+ cells.AMKL chimeric transcription factors are potent inducers of leukemia.Megakaryocyte ontogeny: Clinical and molecular significance.Proteomic analysis of Medulloblastoma reveals functional biology with translational potential.

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P2860

The OTT-MAL fusion oncogene activates RBPJ-mediated transcription and induces acute megakaryoblastic leukemia in a knockin mouse model.

http://www.wikidata.org/entity/Q33383707

description

2009 nî lūn-bûn

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2009 թուականի Մարտին հրատարակուած գիտական յօդուած

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2009 թվականի մարտին հրատարակված գիտական հոդված

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2009年の論文

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The OTT-MAL fusion oncogene ac ...... emia in a knockin mouse model.

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Journal of Clinical Investigation

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The OTT-MAL fusion oncogene ac ...... emia in a knockin mouse model.

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Benjamin H Lee

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D Gary Gilliland

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Dana Cullen

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Glen D Raffel

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Hirokazu Shigematsu

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Ifor R Williams

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Jonathan L Jesneck

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Koichi Akashi

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Marco Giovannini

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Melanie G Cornejo

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P2860

Bioconductor: open software development for computational biology and bioinformatics

Structural basis for cooperativity in recruitment of MAML coactivators to Notch transcription complexes

SHARP is a novel component of the Notch/RBP-Jkappa signalling pathway.

Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles.

Involvement of a human gene related to the Drosophila spen gene in the recurrent t(1;22) translocation of acute megakaryocytic leukemia

A conserved structural motif reveals the essential transcriptional repression function of Spen proteins and their role in developmental signaling

Exploration, normalization, and summaries of high density oligonucleotide array probe level data

Acquired mutations in GATA1 in the megakaryoblastic leukemia of Down syndrome

A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera

Rbm15 modulates Notch-induced transcriptional activation and affects myeloid differentiation

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852-864

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10.1172/JCI35901

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4

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119

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Dominique Bluteau

Nicolas Cagnard

Jean-Pierre Bourquin

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2009-03-16T00:00:00Z

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19287095

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2662544

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