The OTT-MAL fusion oncogene activates RBPJ-mediated transcription and induces acute megakaryoblastic leukemia in a knockin mouse model.
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Megakaryocyte pathology and bone marrow fibrosis: the lysyl oxidase connectionThe aryl hydrocarbon receptor (AHR) transcription factor regulates megakaryocytic polyploidizationGenomic landscape of megakaryopoiesis and platelet function defectsThe biology of pediatric acute megakaryoblastic leukemiaEpigenetic Guardian: A Review of the DNA Methyltransferase DNMT3A in Acute Myeloid Leukaemia and Clonal Haematopoiesis.Role of RhoA-specific guanine exchange factors in regulation of endomitosis in megakaryocytes.Leukaemogenesis induced by an activating β-catenin mutation in osteoblasts.Linking actin dynamics and gene transcription to drive cellular motile functions.The aurora kinases in cell cycle and leukemiaIdentification of regulators of polyploidization presents therapeutic targets for treatment of AMKLNotch signalling in T-cell lymphoblastic leukaemia/lymphoma and other haematological malignancies.Rbm15-Mkl1 interacts with the Setd1b histone H3-Lys4 methyltransferase via a SPOC domain that is required for cytokine-independent proliferation.Ott1 (Rbm15) regulates thrombopoietin response in hematopoietic stem cells through alternative splicing of c-MplCrosstalk between NOTCH and AKT signaling during murine megakaryocyte lineage specificationHematopoietic stem cells lacking Ott1 display aspects associated with aging and are unable to maintain quiescence during proliferative stress.spenito is required for sex determination in Drosophila melanogasterCharacterization of novel genomic alterations and therapeutic approaches using acute megakaryoblastic leukemia xenograft models.Ikaros inhibits megakaryopoiesis through functional interaction with GATA-1 and NOTCH signalingBaicalein antagonizes acute megakaryoblastic leukemia in vitro and in vivo by inducing cell cycle arrestNormal and malignant megakaryopoiesis.Tyrosine 625 plays a key role and cooperates with tyrosine 630 in MPL W515L-induced signaling and myeloproliferative neoplasms.Depletion of the transcriptional coactivators megakaryoblastic leukaemia 1 and 2 abolishes hepatocellular carcinoma xenograft growth by inducing oncogene-induced senescence.Acute Myeloid Leukemia With RBM15-MKL1 Presenting as Severe Hepatic Failure.Bone's dark side: mutated osteoblasts implicated in leukemia.Whole-exome sequencing identifies a novel somatic mutation in MMP8 associated with a t(1;22)-acute megakaryoblastic leukemia.Notch signaling: switching an oncogene to a tumor suppressor.Acute Megakaryoblastic Leukemia with t(1;22) Mimicking Neuroblastoma in an Infant.BMP meets AML: induction of BMP signaling by a novel fusion gene promotes pediatric acute leukemia.Downregulation of GATA1 drives impaired hematopoiesis in primary myelofibrosis.Canonical Notch signaling is dispensible for adult steady-state and stress myelo-erythropoiesis.Tetrandrine antagonizes acute megakaryoblastic leukaemia growth by forcing autophagy-mediated differentiation.PRMT1-RBM15 axis regulates megakaryocytic differentiation of human umbilical cord blood CD34+ cells.AMKL chimeric transcription factors are potent inducers of leukemia.Megakaryocyte ontogeny: Clinical and molecular significance.Proteomic analysis of Medulloblastoma reveals functional biology with translational potential.
P2860
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P2860
The OTT-MAL fusion oncogene activates RBPJ-mediated transcription and induces acute megakaryoblastic leukemia in a knockin mouse model.
description
2009 nî lūn-bûn
@nan
2009 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի մարտին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
The OTT-MAL fusion oncogene ac ...... emia in a knockin mouse model.
@ast
The OTT-MAL fusion oncogene ac ...... emia in a knockin mouse model.
@en
type
label
The OTT-MAL fusion oncogene ac ...... emia in a knockin mouse model.
@ast
The OTT-MAL fusion oncogene ac ...... emia in a knockin mouse model.
@en
prefLabel
The OTT-MAL fusion oncogene ac ...... emia in a knockin mouse model.
@ast
The OTT-MAL fusion oncogene ac ...... emia in a knockin mouse model.
@en
P2093
P2860
P50
P356
P1476
The OTT-MAL fusion oncogene ac ...... emia in a knockin mouse model.
@en
P2093
Benjamin H Lee
D Gary Gilliland
Dana Cullen
Glen D Raffel
Hirokazu Shigematsu
Ifor R Williams
Jonathan L Jesneck
Koichi Akashi
Marco Giovannini
Melanie G Cornejo
P2860
P304
P356
10.1172/JCI35901
P407
P577
2009-03-16T00:00:00Z