Identification of novel peptide substrates for protein farnesyltransferase reveals two substrate classes with distinct sequence selectivities.
about
Structures of Cryptococcus neoformans Protein Farnesyltransferase Reveal Strategies for Developing Inhibitors That Target Fungal PathogensTowards the systematic mapping and engineering of the protein prenylation machinery in Saccharomyces cerevisiaeExpansion of protein farnesyltransferase specificity using "tunable" active site interactions: development of bioengineered prenylation pathways.Protein farnesylation inhibitors cause donut-shaped cell nuclei attributable to a centrosome separation defectIdentification of a novel class of farnesylation targets by structure-based modeling of binding specificity.A combination of metabolic labeling and 2D-DIGE analysis in response to a farnesyltransferase inhibitor facilitates the discovery of new prenylated proteins.Rapid analysis of protein farnesyltransferase substrate specificity using peptide libraries and isoprenoid diphosphate analogues.Splice variants of SmgGDS control small GTPase prenylation and membrane localizationSolid-phase synthesis of C-terminal peptide libraries for studying the specificity of enzymatic protein prenylation.Evaluation of alkyne-modified isoprenoids as chemical reporters of protein prenylation.Protein prenylation: enzymes, therapeutics, and biotechnology applications.Analogs of farnesyl diphosphate alter CaaX substrate specificity and reactions rates of protein farnesyltransferaseExploration of GGTase-I substrate requirements. Part 1: Synthesis and biochemical evaluation of novel aryl-modified geranylgeranyl diphosphate analogs.Exploration of GGTase-I substrate requirements. Part 2: Synthesis and biochemical analysis of novel saturated geranylgeranyl diphosphate analogs.GPS-Lipid: a robust tool for the prediction of multiple lipid modification sites.Recent advances in protein prenyltransferases: substrate identification, regulation, and disease interventions.Prenyltransferase Inhibitors: Treating Human Ailments from Cancer to Parasitic Infections.Metabolic Labeling with an Alkyne-modified Isoprenoid Analog Facilitates Imaging and Quantification of the Prenylome in Cells.Finding a needle in the haystack: computational modeling of Mg2+ binding in the active site of protein farnesyltransferase.Novel covalent modification of human anaplastic lymphoma kinase (ALK) and potentiation of crizotinib-mediated inhibition of ALK activity by BNP7787.Features of reactive cysteines discovered through computation: from kinase inhibition to enrichment around protein degrons.Protein Lipidation: Occurrence, Mechanisms, Biological Functions, and Enabling Technologies.Efficient farnesylation of an extended C-terminal C(x)3X sequence motif expands the scope of the prenylated proteome.Isoprenoids and protein prenylation: implications in the pathogenesis and therapeutic intervention of Alzheimer's disease.
P2860
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P2860
Identification of novel peptide substrates for protein farnesyltransferase reveals two substrate classes with distinct sequence selectivities.
description
2009 nî lūn-bûn
@nan
2009 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Identification of novel peptid ...... stinct sequence selectivities.
@ast
Identification of novel peptid ...... stinct sequence selectivities.
@en
Identification of novel peptid ...... stinct sequence selectivities.
@nl
type
label
Identification of novel peptid ...... stinct sequence selectivities.
@ast
Identification of novel peptid ...... stinct sequence selectivities.
@en
Identification of novel peptid ...... stinct sequence selectivities.
@nl
prefLabel
Identification of novel peptid ...... stinct sequence selectivities.
@ast
Identification of novel peptid ...... stinct sequence selectivities.
@en
Identification of novel peptid ...... stinct sequence selectivities.
@nl
P2093
P2860
P1476
Identification of novel peptid ...... stinct sequence selectivities.
@en
P2093
Carol A Fierke
Heather L Hartman
Katherine A Hicks
Rebekah A Kelly
Terry J Watt
P2860
P304
P356
10.1016/J.JMB.2009.10.038
P407
P577
2009-10-28T00:00:00Z