Lysosomal proteolysis inhibition selectively disrupts axonal transport of degradative organelles and causes an Alzheimer's-like axonal dystrophy.
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Dysregulation of the autophagy-endolysosomal system in amyotrophic lateral sclerosis and related motor neuron diseasesAlterations in Mitochondrial Quality Control in Alzheimer's DiseaseDual roles for autophagy: degradation and secretion of Alzheimer's disease Aβ peptideAxonal transport: cargo-specific mechanisms of motility and regulationCritical pathogenic events underlying progression of neurodegeneration in glaucomaThe synaptic maintenance problem: membrane recycling, Ca2+ homeostasis and late onset degenerationMitochondrial transport in neurons: impact on synaptic homeostasis and neurodegeneration.Axonal autophagosomes recruit dynein for retrograde transport through fusion with late endosomes.Viable neuronopathic Gaucher disease model in Medaka (Oryzias latipes) displays axonal accumulation of alpha-synucleinHuman A53T α-synuclein causes reversible deficits in mitochondrial function and dynamics in primary mouse cortical neuronsSpatial and temporal characteristics of normal and perturbed vesicle transportTECPR2 Associated Neuroaxonal Dystrophy in Spanish Water DogsLysosome and calcium dysregulation in Alzheimer's disease: partners in crimeAxonal Transport and Neurodegeneration: How Marine Drugs Can Be Used for the Development of TherapeuticsAutophagosome dynamics in neurodegeneration at a glanceAutophagy in Neurodegenerative Diseases and Metal NeurotoxicityParkin-mediated mitophagy in mutant hAPP neurons and Alzheimer's disease patient brainsBassoon and Piccolo maintain synapse integrity by regulating protein ubiquitination and degradationThe regulation of autophagosome dynamics by huntingtin and HAP1 is disrupted by expression of mutant huntingtin, leading to defective cargo degradation.Axonal transport and neurodegenerative disease: can we see the elephant?Mitophagy of damaged mitochondria occurs locally in distal neuronal axons and requires PINK1 and ParkinAutophagosomes initiate distally and mature during transport toward the cell soma in primary neurons.Mitochondrial metabolism in Parkinson's disease impairs quality control autophagy by hampering microtubule-dependent traffic.Nicotinamide forestalls pathology and cognitive decline in Alzheimer mice: evidence for improved neuronal bioenergetics and autophagy procession.Autophagosome biogenesis in primary neurons follows an ordered and spatially regulated pathway.LC3 binding to the scaffolding protein JIP1 regulates processive dynein-driven transport of autophagosomes.Formation of α-synuclein Lewy neurite-like aggregates in axons impedes the transport of distinct endosomes.Interactions of noncanonical motifs with hnRNP A2 promote activity-dependent RNA transport in neurons.Pyroglutamate-amyloid-β and glutaminyl cyclase are colocalized with amyloid-β in secretory vesicles and undergo activity-dependent, regulated secretion.Application of microscopical techniques in the study of autolysosome dynamics in PC12 neurites.The GTPase Rab26 links synaptic vesicles to the autophagy pathway.Degradation of misfolded proteins in neurodegenerative diseases: therapeutic targets and strategies.Aging, Alzheimer's, and APOE genotype influence the expression and neuronal distribution patterns of microtubule motor protein dynactin-P50The autophagy gene Wdr45/Wipi4 regulates learning and memory function and axonal homeostasisSpatial parkin translocation and degradation of damaged mitochondria via mitophagy in live cortical neurons.Massive accumulation of luminal protease-deficient axonal lysosomes at Alzheimer's disease amyloid plaquesEndolysosomal Deficits Augment Mitochondria Pathology in Spinal Motor Neurons of Asymptomatic fALS Mice.Positive lysosomal modulation as a unique strategy to treat age-related protein accumulation diseasesPhosphatidic Acid Increases Epidermal Growth Factor Receptor Expression by Stabilizing mRNA Decay and by Inhibiting Lysosomal and Proteasomal Degradation of the Internalized ReceptorRegulation of synaptic activity by snapin-mediated endolysosomal transport and sorting.
P2860
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P2860
Lysosomal proteolysis inhibition selectively disrupts axonal transport of degradative organelles and causes an Alzheimer's-like axonal dystrophy.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
Lysosomal proteolysis inhibiti ...... eimer's-like axonal dystrophy.
@ast
Lysosomal proteolysis inhibiti ...... eimer's-like axonal dystrophy.
@en
type
label
Lysosomal proteolysis inhibiti ...... eimer's-like axonal dystrophy.
@ast
Lysosomal proteolysis inhibiti ...... eimer's-like axonal dystrophy.
@en
prefLabel
Lysosomal proteolysis inhibiti ...... eimer's-like axonal dystrophy.
@ast
Lysosomal proteolysis inhibiti ...... eimer's-like axonal dystrophy.
@en
P2093
P2860
P1476
Lysosomal proteolysis inhibiti ...... eimer's-like axonal dystrophy.
@en
P2093
Ralph A Nixon
Sooyeon Lee
Yutaka Sato
P2860
P304
P356
10.1523/JNEUROSCI.6412-10.2011
P407
P577
2011-05-01T00:00:00Z