Whole chromosome instability caused by Bub1 insufficiency drives tumorigenesis through tumor suppressor gene loss of heterozygosity. - Wikidata - wikimedia - TriplyDB

Whole chromosome instability caused by Bub1 insufficiency drives tumorigenesis through tumor suppressor gene loss of heterozygosity.

Whole chromosome instability caused by Bub1 insufficiency drives tumorigenesis through tumor suppressor gene loss of heterozygosity.

http://www.wikidata.org/entity/Q33743993

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Potential pulmonary effects of engineered carbon nanotubes: in vitro genotoxic effects The CHK2-BRCA1 tumour suppressor pathway ensures chromosomal stability in human somatic cells Loss of pRB causes centromere dysfunction and chromosomal instability Chromosomal instability and cancer: a complex relationship with therapeutic potential Aneuploidy in stem cells Aurora B hyperactivation by Bub1 overexpression promotes chromosome missegregation USP44 regulates centrosome positioning to prevent aneuploidy and suppress tumorigenesis Overexpression of ubiquitin specific protease 44 (USP44) induces chromosomal instability and is frequently observed in human T-cell leukemia The causes and consequences of genetic heterogeneity in cancer evolution Osteosarcomagenesis: modeling cancer initiation in the mouse.MLL5 maintains genomic integrity by regulating the stability of the chromosomal passenger complex through a functional interaction with Borealin Chromosome missegregation rate predicts whether aneuploidy will promote or suppress tumors.An integrated functional genomics approach identifies the regulatory network directed by brachyury (T) in chordoma.Deletion of the MAD2L1 spindle assembly checkpoint gene is tolerated in mouse models of acute T-cell lymphoma and hepatocellular carcinoma.Spartan deficiency causes accumulation of Topoisomerase 1 cleavage complexes and tumorigenesis.Tumor suppressor roles of CENP-E and Nsl1 in Drosophila epithelial tissues.Mitotic chromosome condensation mediated by the retinoblastoma protein is tumor-suppressive Usp7 protects genomic stability by regulating Bub3.Animal models of gastrointestinal and liver diseases. New mouse models for studying dietary prevention of colorectal cancer Tumor antigen acrosin binding protein normalizes mitotic spindle function to promote cancer cell proliferation.Chromosome instability induced by Mps1 and p53 mutation generates aggressive lymphomas exhibiting aneuploidy-induced stress.Cdc20 hypomorphic mice fail to counteract de novo synthesis of cyclin B1 in mitosis.Chromosome missegregation causes colon cancer by APC loss of heterozygosity.Cancer chromosomal instability: therapeutic and diagnostic challenges.Increased expression of BubR1 protects against aneuploidy and cancer and extends healthy lifespan.Centrosome-related genes, genetic variation, and risk of breast cancer.Gibbon genome and the fast karyotype evolution of small apes.Induction of chromosome instability and stomach cancer by altering the expression pattern of mitotic checkpoint genes in mice exposed to areca-nut Paradoxical relationship between chromosomal instability and survival outcome in cancer.Centromere fission, not telomere erosion, triggers chromosomal instability in human carcinomas.Centrosome dynamics as a source of chromosomal instability Bub1 overexpression induces aneuploidy and tumor formation through Aurora B kinase hyperactivation Mad2 is a critical mediator of the chromosome instability observed upon Rb and p53 pathway inhibition.Cyclin B2 and p53 control proper timing of centrosome separation Chromosomal instability substantiates poor prognosis in patients with diffuse large B-cell lymphoma.Aneuploidy and chromosomal instability in cancer: a jackpot to chaos.Thoughts on aneuploidy.Common variation in Nemo-like kinase is associated with risk of ovarian cancer.Genomic DNA Copy Number Aberrations, Histological Diagnosis, Oral Subsite and Aneuploidy in OPMDs/OSCCs.Targeting karyotypic complexity and chromosomal instability of cancer cells.

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P2860

Whole chromosome instability caused by Bub1 insufficiency drives tumorigenesis through tumor suppressor gene loss of heterozygosity.

http://www.wikidata.org/entity/Q33743993

description

2009 nî lūn-bûn

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2009 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

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2009 թվականի դեկտեմբերին հրատարակված գիտական հոդված

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2009年の論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年论文

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Whole chromosome instability c ...... r gene loss of heterozygosity.

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Whole chromosome instability c ...... r gene loss of heterozygosity.

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Whole chromosome instability c ...... r gene loss of heterozygosity.

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Whole chromosome instability c ...... r gene loss of heterozygosity.

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Whole chromosome instability c ...... r gene loss of heterozygosity.

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Whole chromosome instability c ...... r gene loss of heterozygosity.

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Whole chromosome instability c ...... r gene loss of heterozygosity.

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Darren J Baker

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Fang Jin

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Jan M van Deursen

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Karthik B Jeganathan

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P2860

A role for the Adenomatous Polyposis Coli protein in chromosome segregation

Lethality to human cancer cells through massive chromosome loss by inhibition of the mitotic checkpoint.

Aneuploidy: cells losing their balance

Aneuploidy affects proliferation and spontaneous immortalization in mammalian cells

Bub1 mediates cell death in response to chromosome missegregation and acts to suppress spontaneous tumorigenesis

Mad2 overexpression promotes aneuploidy and tumorigenesis in mice

Increased chromosome instability but not cancer predisposition in haploinsufficient Bub3 mice

Bub1 maintains centromeric cohesion by activation of the spindle checkpoint

Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systems

Chromosome missegregation and apoptosis in mice lacking the mitotic checkpoint protein Mad2

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