Bub1 overexpression induces aneuploidy and tumor formation through Aurora B kinase hyperactivation
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MAPping the Ndc80 loop in cancer: A possible link between Ndc80/Hec1 overproduction and cancer formationAurora B hyperactivation by Bub1 overexpression promotes chromosome missegregationReduced life- and healthspan in mice carrying a mono-allelic BubR1 MVA mutationReprogramming to pluripotency can conceal somatic cell chromosomal instabilityUp-regulation of the mitotic checkpoint component Mad1 causes chromosomal instability and resistance to microtubule poisonsThe role of chromosome missegregation in cancer development: a theoretical approach using agent-based modellingAn integrated functional genomics approach identifies the regulatory network directed by brachyury (T) in chordoma.Kinetochore genes are coordinately up-regulated in human tumors as part of a FoxM1-related cell division program.Prolactin-induced protein is required for cell cycle progression in breast cancer.The CINSARC signature as a prognostic marker for clinical outcome in multiple neoplasmsIncreased expression of BubR1 protects against aneuploidy and cancer and extends healthy lifespan.Visual gene-network analysis reveals the cancer gene co-expression in human endometrial cancerIdentification of ovarian cancer associated genes using an integrated approach in a Boolean framework.The chromosomal passenger complex (CPC) as a key orchestrator of orderly mitotic exit and cytokinesis.Screening of feature genes of the ovarian cancer epithelia with DNA microarrayAnalysis and prediction of pathways in HeLa cells by integrating biological levels of organization with systems-biology approachesEctopic TLX1 expression accelerates malignancies in mice deficient in DNA-PK.Oncoprotein YAP regulates the spindle checkpoint activation in a mitotic phosphorylation-dependent manner through up-regulation of BubR1.Phosphorylation of FADD by the kinase CK1α promotes KRASG12D-induced lung cancer.Aneuploidy and chromosomal instability in cancer: a jackpot to chaos.Biological and Clinical Significance of MAD2L1 and BUB1, Genes Frequently Appearing in Expression Signatures for Breast Cancer Prognosis.Single-Cell Based Quantitative Assay of Chromosome Transmission FidelityAurora B Overexpression Causes Aneuploidy and p21Cip1 Repression during Tumor Development.Cell cycle control in acute myeloid leukemia.Bub1 kinase activity drives error correction and mitotic checkpoint control but not tumor suppression.Aneuploidy in health, disease, and aging.Upregulation of colonic and hepatic tumor overexpressed gene is significantly associated with the unfavorable prognosis marker of human hepatocellular carcinoma.Identification of key genes in glioblastoma-associated stromal cells using bioinformatics analysis.High rates of chromosome missegregation suppress tumor progression but do not inhibit tumor initiation.2n or not 2n: Aneuploidy, polyploidy and chromosomal instability in primary and tumor cells.BubR1 alterations that reinforce mitotic surveillance act against aneuploidy and cancerAneuploidy and chromosomal instability: a vicious cycle driving cellular evolution and cancer genome chaos.KNL1 facilitates phosphorylation of outer kinetochore proteins by promoting Aurora B kinase activity.Global analysis of somatic structural genomic alterations and their impact on gene expression in diverse human cancersNew insights into the troubles of aneuploidyTherapeutic relevance of the protein phosphatase 2A in cancer.The Consequences of Chromosome Segregation Errors in Mitosis and Meiosis.Chromosomal instability and aneuploidy in cancer: from yeast to manChromosomal instability, aneuploidy and routine high-resolution DNA content analysis in oral cancer risk evaluation.Genetic instability: tipping the balance.
P2860
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P2860
Bub1 overexpression induces aneuploidy and tumor formation through Aurora B kinase hyperactivation
description
2011 nî lūn-bûn
@nan
2011 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Bub1 overexpression induces an ...... urora B kinase hyperactivation
@en
type
label
Bub1 overexpression induces an ...... urora B kinase hyperactivation
@en
prefLabel
Bub1 overexpression induces an ...... urora B kinase hyperactivation
@en
P2093
P2860
P356
P1476
Bub1 overexpression induces an ...... urora B kinase hyperactivation
@en
P2093
Jan M van Deursen
Karthik B Jeganathan
Robin M Ricke
P2860
P304
P356
10.1083/JCB.201012035
P407
P577
2011-06-06T00:00:00Z