Bub1 overexpression induces aneuploidy and tumor formation through Aurora B kinase hyperactivation - Wikidata - wikimedia - TriplyDB

Bub1 overexpression induces aneuploidy and tumor formation through Aurora B kinase hyperactivation

Bub1 overexpression induces aneuploidy and tumor formation through Aurora B kinase hyperactivation

http://www.wikidata.org/entity/Q35047487

about

MAPping the Ndc80 loop in cancer: A possible link between Ndc80/Hec1 overproduction and cancer formation Aurora B hyperactivation by Bub1 overexpression promotes chromosome missegregation Reduced life- and healthspan in mice carrying a mono-allelic BubR1 MVA mutation Reprogramming to pluripotency can conceal somatic cell chromosomal instability Up-regulation of the mitotic checkpoint component Mad1 causes chromosomal instability and resistance to microtubule poisons The role of chromosome missegregation in cancer development: a theoretical approach using agent-based modelling An integrated functional genomics approach identifies the regulatory network directed by brachyury (T) in chordoma.Kinetochore genes are coordinately up-regulated in human tumors as part of a FoxM1-related cell division program.Prolactin-induced protein is required for cell cycle progression in breast cancer.The CINSARC signature as a prognostic marker for clinical outcome in multiple neoplasms Increased expression of BubR1 protects against aneuploidy and cancer and extends healthy lifespan.Visual gene-network analysis reveals the cancer gene co-expression in human endometrial cancer Identification of ovarian cancer associated genes using an integrated approach in a Boolean framework.The chromosomal passenger complex (CPC) as a key orchestrator of orderly mitotic exit and cytokinesis.Screening of feature genes of the ovarian cancer epithelia with DNA microarray Analysis and prediction of pathways in HeLa cells by integrating biological levels of organization with systems-biology approaches Ectopic TLX1 expression accelerates malignancies in mice deficient in DNA-PK.Oncoprotein YAP regulates the spindle checkpoint activation in a mitotic phosphorylation-dependent manner through up-regulation of BubR1.Phosphorylation of FADD by the kinase CK1α promotes KRASG12D-induced lung cancer.Aneuploidy and chromosomal instability in cancer: a jackpot to chaos.Biological and Clinical Significance of MAD2L1 and BUB1, Genes Frequently Appearing in Expression Signatures for Breast Cancer Prognosis.Single-Cell Based Quantitative Assay of Chromosome Transmission Fidelity Aurora B Overexpression Causes Aneuploidy and p21Cip1 Repression during Tumor Development.Cell cycle control in acute myeloid leukemia.Bub1 kinase activity drives error correction and mitotic checkpoint control but not tumor suppression.Aneuploidy in health, disease, and aging.Upregulation of colonic and hepatic tumor overexpressed gene is significantly associated with the unfavorable prognosis marker of human hepatocellular carcinoma.Identification of key genes in glioblastoma-associated stromal cells using bioinformatics analysis.High rates of chromosome missegregation suppress tumor progression but do not inhibit tumor initiation.2n or not 2n: Aneuploidy, polyploidy and chromosomal instability in primary and tumor cells.BubR1 alterations that reinforce mitotic surveillance act against aneuploidy and cancer Aneuploidy and chromosomal instability: a vicious cycle driving cellular evolution and cancer genome chaos.KNL1 facilitates phosphorylation of outer kinetochore proteins by promoting Aurora B kinase activity.Global analysis of somatic structural genomic alterations and their impact on gene expression in diverse human cancers New insights into the troubles of aneuploidy Therapeutic relevance of the protein phosphatase 2A in cancer.The Consequences of Chromosome Segregation Errors in Mitosis and Meiosis.Chromosomal instability and aneuploidy in cancer: from yeast to man Chromosomal instability, aneuploidy and routine high-resolution DNA content analysis in oral cancer risk evaluation.Genetic instability: tipping the balance.

P2860

Q26991530-A154692A-C238-4761-84B9-BE20DFC7802C Q26995347-79E9AC94-A947-4E89-A99B-BEB158BE1794 Q27329025-1D7840BA-3FFA-4AA6-A047-F46B3240D263 Q28483105-AAFE2947-D1F0-4DA7-B68F-66430E9D35B4 Q30524222-687E0110-1128-4417-8F82-C3C34D25B06D Q31132456-7E12CC86-523C-4D1F-B19A-CA11FB5BD04C Q33274526-A498225B-39EB-42A7-BA0B-F1D17323EE19 Q33811933-13CEF3BD-BC7D-4508-AF48-5B6972B42584 Q33891258-40BA2979-0D71-4BF2-B5BC-8A22C5F03243 Q33905783-55C1EE9B-57D6-434D-A267-8EA49C1400A5 Q34317812-BC3A4B97-873D-4F8D-B7CE-377D37D7D457 Q34525508-3A07F33E-843F-4CFC-9AA8-C7C0E639BDBE Q34577355-D0AE773F-088D-4CFF-B345-E0187A78B990 Q34668857-5F52120D-E7F7-4F21-99AD-6D8896A568F3 Q34759643-3E24948A-4093-4AA1-8A84-C9287776C587 Q34778702-F19FA6D4-5177-4389-B9E3-2C06CB07D387 Q35107819-131E821D-802C-4292-BA78-7359882370BC Q35172929-40C231D7-C012-4F3D-B8D0-DB45D5DEBF33 Q35559013-ABC8074B-74B4-414E-BA8C-5E21259C3D66 Q35646101-013C9654-8FB2-4224-B13A-E7F6025F0099 Q35750136-9AD97405-2616-4454-B804-CAC199833B4D Q35773951-20093ED9-0B02-4DD9-9D50-F9AD9533EE67 Q36070046-B87ED773-82D0-4480-8A22-E997ABD1E2E2 Q36206479-E5D923F0-2A1E-47C9-8427-5151C49AF168 Q36455895-21F370B5-9890-4ED2-95FE-8718D19B4EA8 Q36732750-B22CB9EA-3A75-4322-BCB7-06821DD70F80 Q36853891-C50A22C1-9FCA-4106-BDDF-5DAF15E06CAD Q36954204-ED79619E-9EFF-4BE2-8936-AE7C420F139F Q37052716-57C65A53-551A-4801-B0D2-012492EBC883 Q37078688-7176CB2B-B614-4EA3-8F8C-8F9106F2B77D Q37180403-738D6E36-E74F-419C-9F55-D7D017AC30E0 Q37302999-E51054A5-12B0-457B-8EB3-034C4A66504D Q37411020-F0F3F88A-AE65-4944-A362-F1CC81E2F929 Q37474106-640F9C06-5D0C-4430-947D-E1AB4485707A Q37574324-ED20E3E5-B3B3-4807-8816-2528B07649FA Q37641636-742D4C8B-910C-44BF-9D54-43F2930BBABB Q37728190-D0398F29-7844-4245-841D-CB53BCB9F7A1 Q38011946-192711D0-C4FA-4A90-AC39-5ACCC1744877 Q38058129-99B08D50-B0CC-4BC5-B55D-AEB524C1267B Q38068039-2D173B1C-4FE4-48E7-B887-A0718127A9CF

P2860

Bub1 overexpression induces aneuploidy and tumor formation through Aurora B kinase hyperactivation

http://www.wikidata.org/entity/Q35047487

description

2011 nî lūn-bûn

@nan

2011 թուականի Յունիսին հրատարակուած գիտական յօդուած

@hyw

2011 թվականի հունիսին հրատարակված գիտական հոդված

@hy

2011年の論文

@ja

2011年論文

@yue

2011年論文

@zh-hant

2011年論文

@zh-hk

2011年論文

@zh-mo

2011年論文

@zh-tw

2011年论文

@wuu

name

Bub1 overexpression induces an ...... urora B kinase hyperactivation

@en

type

label

Bub1 overexpression induces an ...... urora B kinase hyperactivation

@en

prefLabel

Bub1 overexpression induces an ...... urora B kinase hyperactivation

@en

P1433

Q35047487-1A45B3A3-F35D-462F-BBAA-AD2B0697D4A3

P1476

Q35047487-76D7699D-63CA-4986-AA72-9B395BB8997F

P2093

Q35047487-5279B2F3-DE1A-4D34-B3AB-F712EA5514C6

Q35047487-C8411301-BC3E-46E4-81D0-393A0729DA5B

Q35047487-D465201F-13EC-4497-AB9D-B7DE8D47BAAB

P2860

Q35047487-037D99F6-63D4-4978-BC4A-9379F96191E1

Q35047487-04235F5A-0C73-4F83-B70B-D6A85AD08DDD

Q35047487-057BE59A-CDAF-4EC1-B6D6-91B92712FF87

Q35047487-0596EFE3-8A5B-444E-8250-1549E14F5439

Q35047487-0B1926B7-0AF6-4ED5-BBEF-0F9D5A4DB357

Q35047487-1027D2D0-47B6-4D96-A4E1-53A1BBDC58DD

Q35047487-1162AA57-30D1-4E78-BF0D-94074B613EE4

Q35047487-11FE6657-2C45-46ED-8E4B-5C6512EE2628

Q35047487-12C41C13-99E8-4A64-AD14-065CAF533304

Q35047487-12F04E62-9A61-4C86-9545-1E2630C8C27D

P304

Q35047487-D83CDEBB-D99A-4C69-BE90-8146278EF9D3

P31

Q35047487-7B9B4CF7-B3A0-4D7F-8CA5-E9144D4B8461

P356

Q35047487-C4C71C93-27B5-426F-9C00-EAFF82320461

P407

Q35047487-0AB3FECB-8FC6-4B84-9D8E-7FD16C7CB1BA

P433

Q35047487-CC423516-2C08-46F7-9354-2932AB5A045F

P478

Q35047487-52B902AF-0A05-4176-BA94-08962D71A213

P577

Q35047487-7E28FF8F-1ADE-475E-B1A6-AFD0828A0667

P5875

Q35047487-B43538CE-98D1-4E1B-9DD3-AC82F18EEDD2

P698

Q35047487-45FF6579-76B5-40D1-9C9B-CFD6BE135F20

P921

Q35047487-1A00AC92-16C0-4D64-A544-D0E39D5AE95B

P932

Q35047487-13E0372A-8BDE-4556-A8C6-DCC57A57A041

P356

P1433

Journal of Cell Biology

P1476

Bub1 overexpression induces an ...... urora B kinase hyperactivation

@en

P2093

Jan M van Deursen

http://www.w3.org/2001/XMLSchema#string

Karthik B Jeganathan

http://www.w3.org/2001/XMLSchema#string

Robin M Ricke

http://www.w3.org/2001/XMLSchema#string

P2860

Characterization of MAD2B and other mitotic spindle checkpoint genes

Histone H3 Thr-3 phosphorylation by Haspin positions Aurora B at centromeres in mitosis.

Crystal structure of the tetrameric Mad1-Mad2 core complex: implications of a 'safety belt' binding mechanism for the spindle checkpoint

Aurora B regulates MCAK at the mitotic centromere

Mps1 phosphorylates Borealin to control Aurora B activity and chromosome alignment

Phosphorylation of Cdc20 by Bub1 provides a catalytic mechanism for APC/C inhibition by the spindle checkpoint

PP2A is required for centromeric localization of Sgo1 and proper chromosome segregation

Bub1 regulates chromosome segregation in a kinetochore-independent manner

Shugoshin 1 plays a central role in kinetochore assembly and is required for kinetochore targeting of Plk1

Mutations of mitotic checkpoint genes in human cancers

P304

1049-1064

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1083/JCB.201012035

http://www.w3.org/2001/XMLSchema#string

P407

P433

6

http://www.w3.org/2001/XMLSchema#string

P478

193

http://www.w3.org/2001/XMLSchema#string

P577

2011-06-06T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

51196580

http://www.w3.org/2001/XMLSchema#string

P698

21646403

http://www.w3.org/2001/XMLSchema#string

P921

P932

3115799

http://www.w3.org/2001/XMLSchema#string