Reaction of antimalarial endoperoxides with specific parasite proteins.
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Purified E255L Mutant SERCA1a and Purified PfATP6 Are Sensitive to SERCA-type Inhibitors but Insensitive to ArtemisininsHaem-activated promiscuous targeting of artemisinin in Plasmodium falciparumArtemisinin-based combination therapies: a vital tool in efforts to eliminate malariaThe Plasmodium falciparum translationally controlled tumor protein homolog and its reaction with the antimalarial drug artemisininDocking studies of structurally diverse antimalarial drugs targeting PfATP6: no correlation between in silico binding affinity and in vitro antimalarial activity.Characterization of the Alkylation Product of Heme by the Antimalarial Drug Artemisinin We are grateful to the CNRS for financial support, and to the French Ministery of Education for a PhD grant to J.C. Dr. Yannick Coppel (LCC-CNRS) is gratefully aReaction of artemisinin with haemoglobin: implications for antimalarial activity.Mechanisms of artemisinin resistance in the rodent malaria pathogen Plasmodium yoelii.Artemisinin resistance in Plasmodium falciparum is associated with an altered temporal pattern of transcription.In vitro and in vivo potentiation of artemisinin and synthetic endoperoxide antimalarial drugs by metalloporphyrinsCysteamine, the molecule used to treat cystinosis, potentiates the antimalarial efficacy of artemisinin.Antimalarial action of artesunate involves DNA damage mediated by reactive oxygen speciesArtesunate tolerance in transgenic Plasmodium falciparum parasites overexpressing a tryptophan-rich protein.Discovery, mechanisms of action and combination therapy of artemisininSafety assessment of peroxide antimalarials: clinical and chemical perspectives.Artemisinin effectiveness in erythrocytes is reduced by heme and heme-containing proteins.The therapeutic potential of semi-synthetic artemisinin and synthetic endoperoxide antimalarial agents.Monoclonal Antibodies That Recognize the Alkylation Signature of Antimalarial Ozonides OZ277 (Arterolane) and OZ439 (Artefenomel).Artemisinin activity-based probes identify multiple molecular targets within the asexual stage of the malaria parasites Plasmodium falciparum 3D7.Artemisinin and the antimalarial endoperoxides: from herbal remedy to targeted chemotherapy.The antimalarial trioxaquine DU1301 alkylates heme in malaria-infected mice.Molecular understanding and modern application of traditional medicines: triumphs and trials.Sesquiterpenoids lactones: benefits to plants and people.Human fortilin is a molecular target of dihydroartemisinin.In vitro activity of anti-malarial ozonides against an artemisinin-resistant isolate.Probing the biology of natural products: molecular editing by diverted total synthesis.Antimalarial drugs: modes of action and mechanisms of parasite resistance.Genetic analysis in mice identifies cysteamine as a novel partner for artemisinin in the treatment of malaria.Target identification with quantitative activity based protein profiling (ABPP).Probing the antimalarial mechanism of artemisinin and OZ277 (arterolane) with nonperoxidic isosteres and nitroxyl radicals.A Click Chemistry-Based Proteomic Approach Reveals that 1,2,4-Trioxolane and Artemisinin Antimalarials Share a Common Protein Alkylation Profile.Peroxide bond-dependent antiplasmodial specificity of artemisinin and OZ277 (RBx11160).Artemisinin as a Chinese medicine, selectively induces apoptosis in pancreatic tumor cell line.Potentiation of artemisinin activity against chloroquine-resistant Plasmodium falciparum strains by using heme modelsImmunoprecipitation of [(3)H]dihydroartemisinin translationally controlled tumor protein (TCTP) adducts from Plasmodium falciparum-infected erythrocytes by using anti-TCTP antibodiesLopinavir/ritonavir enhanced the antimalarial activity of amodiaquine and artesunate in a mouse model of Plasmodium berghei.Investigations into the role of the Plasmodium falciparum SERCA (PfATP6) L263E mutation in artemisinin action and resistance.Relationship between antimalarial activity and heme alkylation for spiro- and dispiro-1,2,4-trioxolane antimalarials.In vitro interaction of artemisinin derivatives or the fully synthetic peroxidic anti-malarial OZ277 with thapsigargin in Plasmodium falciparum strains.A Click Chemistry-Based Proteomic Approach Reveals that 1,2,4-Trioxolane and Artemisinin Antimalarials Share a Common Protein Alkylation Profile.
P2860
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P2860
Reaction of antimalarial endoperoxides with specific parasite proteins.
description
1994 nî lūn-bûn
@nan
1994 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
1994 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
1994年の論文
@ja
1994年論文
@yue
1994年論文
@zh-hant
1994年論文
@zh-hk
1994年論文
@zh-mo
1994年論文
@zh-tw
1994年论文
@wuu
name
Reaction of antimalarial endoperoxides with specific parasite proteins.
@ast
Reaction of antimalarial endoperoxides with specific parasite proteins.
@en
type
label
Reaction of antimalarial endoperoxides with specific parasite proteins.
@ast
Reaction of antimalarial endoperoxides with specific parasite proteins.
@en
prefLabel
Reaction of antimalarial endoperoxides with specific parasite proteins.
@ast
Reaction of antimalarial endoperoxides with specific parasite proteins.
@en
P2093
P2860
P356
P1476
Reaction of antimalarial endoperoxides with specific parasite proteins.
@en
P2093
S R Meshnick
W Asawamahasakda
P2860
P304
P356
10.1128/AAC.38.8.1854
P407
P577
1994-08-01T00:00:00Z