Positively charged retinoids are potent and selective inhibitors of the trans-cis isomerization in the retinoid (visual) cycle - Wikidata - wikimedia - TriplyDB

Positively charged retinoids are potent and selective inhibitors of the trans-cis isomerization in the retinoid (visual) cycle

Positively charged retinoids are potent and selective inhibitors of the trans-cis isomerization in the retinoid (visual) cycle

http://www.wikidata.org/entity/Q33852276

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Retinopathy in mice induced by disrupted all-trans-retinal clearance Structure of RPE65 isomerase in a lipidic matrix reveals roles for phospholipids and iron in catalysis.Retinol Dehydrogenases Regulate Vitamin A Metabolism for Visual Function Catalytic mechanism of a retinoid isomerase essential for vertebrate vision RPE65, visual cycle retinol isomerase, is not inherently 11-cis-specific: support for a carbocation mechanism of retinol isomerization Membrane-binding and enzymatic properties of RPE65 Visual Cycle Modulation as an Approach toward Preservation of Retinal Integrity Norbixin Protects Retinal Pigmented Epithelium Cells and Photoreceptors against A2E-Mediated Phototoxicity In Vitro and In Vivo Metabolic basis of visual cycle inhibition by retinoid and nonretinoid compounds in the vertebrate retina Pharmacological Amelioration of Cone Survival and Vision in a Mouse Model for Leber Congenital Amaurosis Inner retinal photoreception independent of the visual retinoid cycle.Identification of nonvisual photomotor response cells in the vertebrate hindbrain Evaluation of 9-cis-retinyl acetate therapy in Rpe65-/- mice Retinyl ester storage particles (retinosomes) from the retinal pigmented epithelium resemble lipid droplets in other tissues Noninvasive two-photon microscopy imaging of mouse retina and retinal pigment epithelium through the pupil of the eye.Phospholipid meets all-trans-retinal: the making of RPE bisretinoids Rational Tuning of Visual Cycle Modulator Pharmacodynamics Retinoids for treatment of retinal diseases Effects of potent inhibitors of the retinoid cycle on visual function and photoreceptor protection from light damage in mice.The biochemical and structural basis for trans-to-cis isomerization of retinoids in the chemistry of vision.Pharmacological inhibition of lipofuscin accumulation in the retina as a therapeutic strategy for dry AMD treatment.Beta,beta-carotene decreases peroxisome proliferator receptor gamma activity and reduces lipid storage capacity of adipocytes in a beta,beta-carotene oxygenase 1-dependent manner Retinal degeneration in animal models with a defective visual cycle.Inhibition of the visual cycle by A2E through direct interaction with RPE65 and implications in Stargardt disease.Dry age-related macular degeneration: A currently unmet clinical need.Phase ii, randomized, placebo-controlled, 90-day study of emixustat hydrochloride in geographic atrophy associated with dry age-related macular degeneration Topology and membrane association of lecithin: retinol acyltransferase.The role of 11-cis-retinyl esters in vertebrate cone vision.Influence of blue light on photoreceptors in a live retinal explant system.Aberrant metabolites in mouse models of congenital blinding diseases: formation and storage of retinyl esters.Expansion of first-in-class drug candidates that sequester toxic all-trans-retinal and prevent light-induced retinal degeneration.Key enzymes of the retinoid (visual) cycle in vertebrate retina Prolonged prevention of retinal degeneration with retinylamine loaded nanoparticles.Improvement in rod and cone function in mouse model of Fundus albipunctatus after pharmacologic treatment with 9-cis-retinal.Mechanism of all-trans-retinal toxicity with implications for stargardt disease and age-related macular degeneration.The bisretinoids of retinal pigment epithelium Manganese-Enhanced MRI for Preclinical Evaluation of Retinal Degeneration Treatments Molecular pharmacodynamics of emixustat in protection against retinal degeneration.Retinylamine Benefits Early Diabetic Retinopathy in Mice Retinal photodamage mediated by all-trans-retinal.

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P2860

Positively charged retinoids are potent and selective inhibitors of the trans-cis isomerization in the retinoid (visual) cycle

http://www.wikidata.org/entity/Q33852276

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2005 nî lūn-bûn

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Proceedings of the National Academy of Sciences of the United States of America

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Alexander R Moise

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Marcin Golczak

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Tadao Maeda

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Vladimir Kuksa

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P2860

Essential role of Ca2+-binding protein 4, a Cav1.4 channel regulator, in photoreceptor synaptic function.

A photoreceptor cell-specific ATP-binding transporter gene (ABCR) is mutated in recessive Stargardt macular dystrophy

Noninvasive two-photon imaging reveals retinyl ester storage structures in the eye

9-cis retinoic acid is a high affinity ligand for the retinoid X receptor

Insights into the function of Rim protein in photoreceptors and etiology of Stargardt's disease from the phenotype in abcr knockout mice

The retinoic acid-metabolizing enzyme, CYP26A1, is essential for normal hindbrain patterning, vertebral identity, and development of posterior structures.

Synthesis and characterization of a novel retinylamine analog inhibitor of constitutively active rhodopsin mutants found in patients with autosomal dominant retinitis pigmentosa

Recovery of visual functions in a mouse model of Leber congenital amaurosis

A decade of molecular biology of retinoic acid receptors

Characterization of an autoregulated response element in the mouse retinoic acid receptor type beta gene

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Krzysztof Palczewski

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