Ligand-mediated tertiary structure changes of reconstituted P-glycoprotein. A tryptophan fluorescence quenching analysis.
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Repacking of the transmembrane domains of P-glycoprotein during the transport ATPase cycleProviding a molecular mechanism for P-glycoprotein; why would I bother?Detailed characterization of cysteine-less P-glycoprotein reveals subtle pharmacological differences in function from wild-type proteinStructural and functional asymmetry of the nucleotide-binding domains of P-glycoprotein investigated by attenuated total reflection Fourier transform infrared spectroscopyThe homodimeric ATP-binding cassette transporter LmrA mediates multidrug transport by an alternating two-site (two-cylinder engine) mechanismSecondary and tertiary structure changes of reconstituted LmrA induced by nucleotide binding or hydrolysis. A fourier transform attenuated total reflection infrared spectroscopy and tryptophan fluorescence quenching analysis.Intermediate structural states involved in MRP1-mediated drug transport. Role of glutathione.Identification and characterization of the binding sites of P-glycoprotein for multidrug resistance-related drugs and modulators.The translocation mechanism of P-glycoprotein.Transmembrane transport of endo- and xenobiotics by mammalian ATP-binding cassette multidrug resistance proteins.Unravelling the complex drug-drug interactions of the cardiovascular drugs, verapamil and digoxin, with P-glycoprotein.Structure and function of ABC transporters.Interaction of human serum albumin with novel 3,9-disubstituted perylenesStructures of the Multidrug Transporter P-glycoprotein Reveal Asymmetric ATP Binding and the Mechanism of Polyspecificity.Maltose-binding protein is open in the catalytic transition state for ATP hydrolysis during maltose transport.Tryptophan fluorescence quenching by enzyme inhibitors as a tool for enzyme active site structure investigation: epoxide hydrolase.The coupling mechanism of P-glycoprotein involves residue L339 in the sixth membrane spanning segment.The topography of transmembrane segment six is altered during the catalytic cycle of P-glycoprotein.Nucleotide-induced conformational changes in the human multidrug resistance protein MRP1 are related to the capacity of chemotherapeutic drugs to accumulate or not in resistant cells.A conformation change in the carboxyl terminus of Alzheimer's Abeta (1-40) accompanies the transition from dimer to fibril as revealed by fluorescence quenching analysis.Transmembrane helix 12 modulates progression of the ATP catalytic cycle in ABCB1.Two neonatal diabetes mutations on transmembrane helix 15 of SUR1 increase affinity for ATP and ADP at nucleotide binding domain 2.Cooperativity between verapamil and ATP bound to the efflux transporter P-glycoprotein.Transition state analysis of the coupling of drug transport to ATP hydrolysis by P-glycoprotein.Mapping daunorubicin-binding Sites in the ATP-binding cassette transporter MsbA using site-specific quenching by spin labels.The Q-loop disengages from the first intracellular loop during the catalytic cycle of the multidrug ABC transporter BmrA.Molecular dynamics simulations of E. coli MsbA transmembrane domain: formation of a semipore structureThree-dimensional structures of the mammalian multidrug resistance P-glycoprotein demonstrate major conformational changes in the transmembrane domains upon nucleotide binding.Many P-glycoprotein substrates do not inhibit the transport process across cell membranes.P-glycoprotein retains function when reconstituted into a sphingolipid- and cholesterol-rich environment.Concentration dependency of modulatory effect of amlodipine on P-glycoprotein efflux activity of doxorubicin--a comparison with tamoxifen.Autofluorescence and Nonspecific Immunofluorescent Labeling in Frozen Bovine Intestinal Tissue Sections: Solutions for Multicolor Immunofluorescence Experiments.Substitution at the C-3 Position of Catechins Has an Influence on the Binding Affinities against Serum Albumin.Shedding light on drug transport: structure and function of the P-glycoprotein multidrug transporter (ABCB1).A novel ligand bound ABC transporter, LolCDE, provides insights into the molecular mechanisms underlying membrane detachment of bacterial lipoproteins.The flexibility of P-glycoprotein for its poly-specific drug binding from molecular dynamics simulations
P2860
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P2860
Ligand-mediated tertiary structure changes of reconstituted P-glycoprotein. A tryptophan fluorescence quenching analysis.
description
1999 nî lūn-bûn
@nan
1999 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի հունիսին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
Ligand-mediated tertiary struc ...... uorescence quenching analysis.
@ast
Ligand-mediated tertiary struc ...... uorescence quenching analysis.
@en
type
label
Ligand-mediated tertiary struc ...... uorescence quenching analysis.
@ast
Ligand-mediated tertiary struc ...... uorescence quenching analysis.
@en
prefLabel
Ligand-mediated tertiary struc ...... uorescence quenching analysis.
@ast
Ligand-mediated tertiary struc ...... uorescence quenching analysis.
@en
P2093
P2860
P356
P1476
Ligand-mediated tertiary struc ...... uorescence quenching analysis.
@en
P2093
A B Shapiro
J M Ruysschaert
N Sonveaux
P2860
P304
17649-17654
P356
10.1074/JBC.274.25.17649
P407
P577
1999-06-01T00:00:00Z