The HRDC domain of BLM is required for the dissolution of double Holliday junctions
about
Different quaternary structures of human RECQ1 are associated with its dual enzymatic activityBLAP75/RMI1 promotes the BLM-dependent dissolution of homologous recombination intermediatesThe RecQ DNA helicases in DNA repairHuman premature aging, DNA repair and RecQ helicasesThe Bloom's syndrome helicase promotes the annealing of complementary single-stranded DNAReplication of Structured DNA and its implication in epigenetic stabilityCrystal structure of the HRDC domain of human Werner syndrome protein, WRNStructure and function of the regulatory C-terminal HRDC domain from Deinococcus radiodurans RecQStructure and function of the regulatory HRDC domain from human Bloom syndrome proteinStructure of the RecQ C-terminal domain of human Bloom syndrome proteinStructure of human Bloom's syndrome helicase in complex with ADP and duplex DNAAn essential DNA strand-exchange activity is conserved in the divergent N-termini of BLM orthologs.Evidence that a RecQ helicase slows senescence by resolving recombining telomeresThe broken genome: genetic and pharmacologic approaches to breaking DNARECQL5 and BLM exhibit divergent functions in cells defective for the Fanconi anemia pathwayCrystal structure of the Bloom's syndrome helicase indicates a role for the HRDC domain in conformational changesHuman RECQ1 is a DNA damage responsive protein required for genotoxic stress resistance and suppression of sister chromatid exchanges.The RTR Complex Partner RMI2 and the DNA Helicase RTEL1 Are Both Independently Involved in Preserving the Stability of 45S rDNA Repeats in Arabidopsis thaliana.WRN helicase defective in the premature aging disorder Werner syndrome genetically interacts with topoisomerase 3 and restores the top3 slow growth phenotype of sgs1 top3Distinct roles of RECQ1 in the maintenance of genomic stability.The full-length Saccharomyces cerevisiae Sgs1 protein is a vigorous DNA helicase that preferentially unwinds holliday junctions.Meiotic recombination intermediates are resolved with minimal crossover formation during return-to-growth, an analogue of the mitotic cell cycleSubstrate specific stimulation of NEIL1 by WRN but not the other human RecQ helicases.When transcription meets recombination: a lesson from the human RECQ protein complexesSgs1 and Exo1 suppress targeted chromosome duplication during ends-in and ends-out gene targeting.Recruitment and retention dynamics of RECQL5 at DNA double strand break sites.Recruitment of HRDC domain of WRN and BLM to the sites of DNA damage induced by mitomycin C and methyl methanesulfonate.The dissolution of double Holliday junctions.A small molecule inhibitor of the BLM helicase modulates chromosome stability in human cells.Mechanistic insight into the interaction of BLM helicase with intra-strand G-quadruplex structuresCharacterization of biochemical properties of Bacillus subtilis RecQ helicaseHolliday junction processing activity of the BLM-Topo IIIalpha-BLAP75 complex.Sgs1 truncations induce genome rearrangements but suppress detrimental effects of BLM overexpression in Saccharomyces cerevisiae.RMI1 attenuates tumor development and is essential for early embryonic survivalThe absence of Top3 reveals an interaction between the Sgs1 and Pif1 DNA helicases in Saccharomyces cerevisiae.Sit down, relax and unwind: structural insights into RecQ helicase mechanisms.Template disruptions and failure of double Holliday junction dissolution during double-strand break repair in Drosophila BLM mutants.Roles of type 1A topoisomerases in genome maintenance in Escherichia coli.Prelude to a divisionRECQL, a member of the RecQ family of DNA helicases, suppresses chromosomal instability.
P2860
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P2860
The HRDC domain of BLM is required for the dissolution of double Holliday junctions
description
2005 nî lūn-bûn
@nan
2005 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
The HRDC domain of BLM is required for the dissolution of double Holliday junctions
@ast
The HRDC domain of BLM is required for the dissolution of double Holliday junctions
@en
type
label
The HRDC domain of BLM is required for the dissolution of double Holliday junctions
@ast
The HRDC domain of BLM is required for the dissolution of double Holliday junctions
@en
prefLabel
The HRDC domain of BLM is required for the dissolution of double Holliday junctions
@ast
The HRDC domain of BLM is required for the dissolution of double Holliday junctions
@en
P2093
P2860
P356
P1433
P1476
The HRDC domain of BLM is required for the dissolution of double Holliday junctions
@en
P2093
Alessandro Vindigni
Christine Ralf
Douglas A Bernstein
Ian D Hickson
James L Keck
Kok Lung Chan
Leonard Wu
Patrick L Garcia
Pavel Janscak
Vilhelm A Bohr
P2860
P304
P356
10.1038/SJ.EMBOJ.7600740
P407
P577
2005-06-30T00:00:00Z