Computational design of antibody-affinity improvement beyond in vivo maturation - Wikidata - wikimedia - TriplyDB

Computational design of antibody-affinity improvement beyond in vivo maturation

Computational design of antibody-affinity improvement beyond in vivo maturation

http://www.wikidata.org/entity/Q33576857

about

Computational design of a PDZ domain peptide inhibitor that rescues CFTR activity Toward high-resolution homology modeling of antibody Fv regions and application to antibody-antigen docking The SWISS-MODEL Repository and associated resources Beyond phage display: non-traditional applications of the filamentous bacteriophage as a vaccine carrier, therapeutic biologic, and bioconjugation scaffold.The development of immunoconjugates for targeted cancer therapy Predicting resistance mutations using protein design algorithms Rationalization and Design of the Complementarity Determining Region Sequences in an Antibody-Antigen Recognition Interface SnugDock: paratope structural optimization during antibody-antigen docking compensates for errors in antibody homology models Protein design using continuous rotamers Affinity- and specificity-enhancing mutations are frequent in multispecific interactions between TIMP2 and MMPs Computational design of protein-based inhibitors of Plasmodium vivax subtilisin-like 1 protease Matched Peptides: Tuning Matched Molecular Pair Analysis for Biopharmaceutical Applications Outcome of a workshop on applications of protein models in biomedical research Advances in Antibody Design Multi-constraint computational design suggests that native sequences of germline antibody H3 loops are nearly optimal for conformational flexibility Computational protein design: the Proteus software and selected applications.Protein side-chain modeling with a protein-dependent optimized rotamer library.Computational tools for epitope vaccine design and evaluation Rotamer optimization for protein design through MAP estimation and problem-size reduction.Thermodynamics of antibody-antigen interaction revealed by mutation analysis of antibody variable regions.MoFvAb: Modeling the Fv region of antibodies.The Framework of Computational Protein Design.Achievements and Challenges in Computational Protein Design.Designing artificial enzymes by intuition and computation Antibody H3 Structure Prediction.Designing specific protein-protein interactions using computation, experimental library screening, or integrated methods Analysis of fast boundary-integral approximations for modeling electrostatic contributions of molecular binding Synthetic antibody libraries focused towards peptide ligands.Structure-based design of a T-cell receptor leads to nearly 100-fold improvement in binding affinity for pepMHC.Evaluation of an inverse molecular design algorithm in a model binding site OptCDR: a general computational method for the design of antibody complementarity determining regions for targeted epitope binding.Beyond natural antibodies: the power of in vitro display technologies.Decomposing the energetic impact of drug resistant mutations in HIV-1 protease on binding DRV.Anchored design of protein-protein interfaces.An efficient method for variable region assembly in the construction of scFv phage display libraries using independent strand amplification.OSPREY: protein design with ensembles, flexibility, and provable algorithms.Specific increase in potency via structure-based design of a TCR.Proven in vitro evolution of protease cathepsin E-inhibitors and -activators at pH 4.5 using a paired peptide method.Antibody affinity maturation using yeast display with detergent-solubilized membrane proteins as antigen sources Rapid optimization and prototyping for therapeutic antibody-like molecules.

P2860

Q21145315-8A59F063-B623-4C61-86A6-ADE1E0C24F96 Q24603390-D05AFE4F-68D3-4E36-95A9-9AC148A26B43 Q24656047-061008E6-9029-44F3-9537-5061D655EC39 Q26795483-B9CC7CE1-232A-4822-A1EF-B578C6A9BDB1 Q27021990-1E687061-2793-4F7F-BDC8-F62C1D46E15B Q27663576-ACE32D13-A3F9-4CA9-8E3B-0AF9E47DB5C1 Q27678251-50D67D9C-A941-4332-B701-97C7AC37B0AD Q28472510-EA8CA52E-20F8-42F4-B898-AAC0274F2828 Q28478881-D2A11B83-83D9-4563-A39E-F109FB085562 Q28542042-4337DB93-4464-4E30-B3A8-CF4921DC0283 Q28544098-79B3E678-32EA-4CE7-BDB9-8AAC7445AB22 Q28607086-313203B3-35A6-4277-BC65-0379124F6D71 Q28751701-B4584216-5BA2-4D00-962D-766DDCA09680 Q28817608-52C7A70F-ACDC-46E2-BC26-FD932528D3CA Q28914723-D39E05ED-F32E-4D43-83CA-DEBC485558DE Q30009563-0898A81E-437F-4DFF-B6F9-B8CE9E8F9046 Q30360147-355BF034-B69A-4AC2-AAED-0C4FA40B5453 Q30373339-F894916B-642B-42CB-8FC5-13066C8489C7 Q30374208-0F6BD676-A7D3-4BA0-8B0B-2989602237EB Q30374518-68550674-D213-40AD-B05C-E7D9A5C931D0 Q30376735-8051BDAD-ABFF-496A-A282-3E5E6AED3E94 Q30395936-C3D55A08-D828-4777-9A5D-4F49B1C48096 Q30395939-40D5870B-64D1-48E0-8098-D60973CC867E Q30396924-1E6C93A2-A39B-4358-9B5E-AAD92C0245F3 Q30398990-525EB49E-AD1C-41B7-89A3-25D45099CEF1 Q30416858-803E3A9E-4B89-4FBC-803C-8F67E80A98CC Q30444203-4E5C837F-E2ED-4865-9BDE-598F7C989F8E Q33326776-37123DC3-83F7-4A8D-8296-F84E6326021B Q33366003-C3F26AEB-EE24-4950-8F70-55F0FD15F3F3 Q33373402-6A7509AA-B313-4E5F-97CD-47374498BB33 Q33694202-E87E8813-3BF6-4E69-84B1-4BF0F693C99A Q33841864-39DDA403-6E68-4252-8CF0-F03D65A7C87E Q33899351-E6FE7C85-3AE5-444C-B333-E3E10E27F95D Q33940656-5217501F-95A9-4C76-B25B-1E4FC244152A Q34301659-E5566715-799F-4DCD-ACA5-62F7165DD982 Q34328545-C7975B6D-BE03-4159-8C94-024E1CB3689B Q34383054-D49DBB7A-9E86-4E5B-A8A7-A17C5FA9F078 Q34460074-C901A500-CBB8-4F33-9245-1191699C718E Q34460171-EE7820AE-C319-4741-9219-98578FB071FD Q34580658-BBC6E4EA-6775-48EB-A93C-7834D233745F

P2860

Computational design of antibody-affinity improvement beyond in vivo maturation

http://www.wikidata.org/entity/Q33576857

description

2007 nî lūn-bûn

@nan

2007 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

@hyw

2007 թվականի սեպտեմբերին հրատարակված գիտական հոդված

@hy

2007年の論文

@ja

2007年論文

@yue

2007年論文

@zh-hant

2007年論文

@zh-hk

2007年論文

@zh-mo

2007年論文

@zh-tw

2007年论文

@wuu

name

Computational design of antibody-affinity improvement beyond in vivo maturation

@ast

Computational design of antibody-affinity improvement beyond in vivo maturation

@en

Computational design of antibody-affinity improvement beyond in vivo maturation.

@nl

type

label

Computational design of antibody-affinity improvement beyond in vivo maturation

@ast

Computational design of antibody-affinity improvement beyond in vivo maturation

@en

Computational design of antibody-affinity improvement beyond in vivo maturation.

@nl

prefLabel

Computational design of antibody-affinity improvement beyond in vivo maturation

@ast

Computational design of antibody-affinity improvement beyond in vivo maturation

@en

Computational design of antibody-affinity improvement beyond in vivo maturation.

@nl

P1433

Q33576857-155B7490-9F49-4A71-9AD6-3157A50D2479

P1476

Q33576857-8BF846B4-FF1D-4F94-AC74-C26156319C11

P2093

Q33576857-2D2885E4-7D1E-4465-B20B-35E847CB3477

Q33576857-5ADC64D5-BE68-4429-8391-BD83B91F7FDE

P2860

Q33576857-01DA93C0-EC50-4AD1-9B5E-8C7AA46BF735

Q33576857-05C1312D-9935-4207-B028-8538EEA57AD2

Q33576857-097A8A9B-2CC5-419E-8734-C6B468E76855

Q33576857-0C8BBCB0-69EF-46C6-921B-A88F89689DF3

Q33576857-1B9A864D-6974-483D-8616-31D1B5C9C829

Q33576857-3B152F3F-B5B8-4CA4-8C7A-B5C102652C04

Q33576857-42063D70-BAF9-4FDC-872F-1761C6487980

Q33576857-579FCF3B-B839-47CA-AC8F-3E22FB502821

Q33576857-5AC74F35-2B08-4072-82C1-AAA6267B2D29

Q33576857-669C8B78-4CD8-4CDD-9D7E-604BE9101F74

P2888

Q33576857-209E03EC-D5DC-4734-85D5-2C3EFCDE0ECB

P304

Q33576857-C2BFC13E-2129-43EC-B100-D0577D3ED912

P31

Q33576857-81DDBF2A-A044-4B71-9DC6-FBC8B7822009

P356

Q33576857-BD911DC6-79DF-4298-AC92-CE21A5441155

P433

Q33576857-F34C5D13-157A-4893-8E9B-CBEB0C28FA1F

P478

Q33576857-81094F91-7777-425C-A5E7-258CD8553ABC

P50

Q33576857-1807A6E9-830C-4890-84D8-CBCA25FC6D6D

P577

Q33576857-882D8756-B037-417E-886B-F5C53EC4DD80

P5875

Q33576857-C6D2CA32-8924-4058-BA6D-B860525CA2DD

P698

Q33576857-214D79AD-51EE-4520-A83A-E61EDFAFF925

P921

Q33576857-D391C646-35B2-4DEC-86B4-413B65B30B55

P932

Q33576857-6C33A646-70CB-44E6-8E35-BA6494713ED1

P356

P1433

Nature Biotechnology

P1476

Computational design of antibody-affinity improvement beyond in vivo maturation

@en

P2093

K Dane Wittrup

http://www.w3.org/2001/XMLSchema#string

Shaun M Lippow

http://www.w3.org/2001/XMLSchema#string

P2860

Design of a Novel Globular Protein Fold with Atomic-Level Accuracy

Computational redesign of endonuclease DNA binding and cleavage specificity

Selection and analysis of an optimized anti-VEGF antibody: crystal structure of an affinity-matured Fab in complex with antigen

De novo protein design: fully automated sequence selection

Rational design of intercellular adhesion molecule-1 (ICAM-1) variants for antagonizing integrin lymphocyte function-associated antigen-1-dependent adhesion

Computational design of receptor and sensor proteins with novel functions.

On the nonpolar hydration free energy of proteins: surface area and continuum solvent models for the solute-solvent interaction energy.

Theoretical and experimental studies of biotin analogues that bind almost as tightly to streptavidin as biotin.

Directed evolution of antibody fragments with monovalent femtomolar antigen-binding affinity.

Specificity versus stability in computational protein design

P2888

P304

1171-1176

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1038/NBT1336

http://www.w3.org/2001/XMLSchema#string

P433

10

http://www.w3.org/2001/XMLSchema#string

P478

25

http://www.w3.org/2001/XMLSchema#string

P50

P577

2007-09-23T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

5953375

http://www.w3.org/2001/XMLSchema#string

P698

17891135

http://www.w3.org/2001/XMLSchema#string

P921

P932

2803018

http://www.w3.org/2001/XMLSchema#string