Drosophila histone deacetylase 6 protects dopaminergic neurons against {alpha}-synuclein toxicity by promoting inclusion formation. - Wikidata - wikimedia - TriplyDB

Drosophila histone deacetylase 6 protects dopaminergic neurons against {alpha}-synuclein toxicity by promoting inclusion formation.

Drosophila histone deacetylase 6 protects dopaminergic neurons against {alpha}-synuclein toxicity by promoting inclusion formation.

http://www.wikidata.org/entity/Q33948478

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Identification of novel ATP13A2 interactors and their role in α-synuclein misfolding and toxicity HDAC6 regulates mutant SOD1 aggregation through two SMIR motifs and tubulin acetylation HDAC6 as a target for neurodegenerative diseases: what makes it different from the other HDACs?Autophagy in neurodegenerative diseases: from mechanism to therapeutic approach ATP13A2 and Alpha-synuclein: a Metal Taste in Autophagy Endonuclease G mediates α-synuclein cytotoxicity during Parkinson's disease Septins promote dendrite and axon development by negatively regulating microtubule stability via HDAC6-mediated deacetylation.Hdac6 knock-out increases tubulin acetylation but does not modify disease progression in the R6/2 mouse model of Huntington's disease Insecticidal activities of histone deacetylase inhibitors against a dipteran parasite of sheep, Lucilia cuprina Genetic deletion of the Histone Deacetylase 6 exacerbates selected behavioral deficits in the R6/1 mouse model for Huntington's disease.Histone deacetylases suppress CGG repeat-induced neurodegeneration via transcriptional silencing in models of fragile X tremor ataxia syndrome.The mitochondrial chaperone protein TRAP1 mitigates α-Synuclein toxicity Cellular strategies of protein quality control.α-Synuclein Transgenic Drosophila As a Model of Parkinson's Disease and Related Synucleinopathies.Drosophila models of Parkinson's disease: discovering relevant pathways and novel therapeutic strategies.A Drosophila model of FUS-related neurodegeneration reveals genetic interaction between FUS and TDP-43.Heat shock protein-70 (Hsp-70) suppresses paraquat-induced neurodegeneration by inhibiting JNK and caspase-3 activation in Drosophila model of Parkinson's disease.Genetic activation of Nrf2 signaling is sufficient to ameliorate neurodegenerative phenotypes in a Drosophila model of Parkinson's disease.High Throughput Sequencing Identifies MicroRNAs Mediating α-Synuclein Toxicity by Targeting Neuroactive-Ligand Receptor Interaction Pathway in Early Stage of Drosophila Parkinson's Disease Model.RAN translation at CGG repeats induces ubiquitin proteasome system impairment in models of fragile X-associated tremor ataxia syndrome HDAC6 mutations rescue human tau-induced microtubule defects in Drosophila.Uncoupling of Protein Aggregation and Neurodegeneration in a Mouse Amyotrophic Lateral Sclerosis Model.RNA-binding proteins in neurodegenerative disease: TDP-43 and beyond.Various applications of TALEN- and CRISPR/Cas9-mediated homologous recombination to modify the Drosophila genome.To prevent neurodegeneration: HDAC6 uses different strategies for different challenges.The axon initial segment in nervous system disease and injury Interplay between histone deacetylases and autophagy--from cancer therapy to neurodegeneration.HDAC6 at the Intersection of Neuroprotection and Neurodegeneration.Histone deacetylase 6 in health and disease.Drosophila Answers to TDP-43 Proteinopathies.The Role of Histone Deacetylase 6 in Synaptic Plasticity and Memory.Increased acetylation of microtubules rescues human tau-induced microtubule defects and neuromuscular junction abnormalities in Drosophila.Epigenetics in Parkinson's Disease.Histone deacetylases (HDACs) in frontotemporal lobar degeneration.Metabolomic Analysis Provides Insights on Paraquat-Induced Parkinson-Like Symptoms in Drosophila melanogaster.Systemic anti-vascular endothelial growth factor therapies induce a painful sensory neuropathy.HDAC6 and RhoA are novel players in Abeta-driven disruption of neuronal polarity.Class II HDACs and neuronal regeneration.Genetics and epigenetics of Parkinson's disease.Modeling Parkinson's Disease in Drosophila: What Have We Learned for Dominant Traits?

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P2860

Drosophila histone deacetylase 6 protects dopaminergic neurons against {alpha}-synuclein toxicity by promoting inclusion formation.

http://www.wikidata.org/entity/Q33948478

description

2010 nî lūn-bûn

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2010 թուականի Մայիսին հրատարակուած գիտական յօդուած

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2010 թվականի մայիսին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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name

Drosophila histone deacetylase ...... promoting inclusion formation.

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Drosophila histone deacetylase ...... promoting inclusion formation.

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type

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Drosophila histone deacetylase ...... promoting inclusion formation.

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Drosophila histone deacetylase ...... promoting inclusion formation.

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Drosophila histone deacetylase ...... promoting inclusion formation.

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Drosophila histone deacetylase ...... promoting inclusion formation.

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Molecular Biology of the Cell

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Drosophila histone deacetylase ...... promoting inclusion formation.

@en

P2093

Chih-Chen Wang

http://www.w3.org/2001/XMLSchema#string

Guiping Du

http://www.w3.org/2001/XMLSchema#string

Mei Song

http://www.w3.org/2001/XMLSchema#string

Renjie Jiao

http://www.w3.org/2001/XMLSchema#string

Xiang Liu

http://www.w3.org/2001/XMLSchema#string

Xinping Chen

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Yan Yan

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P2860

Parkinson's disease: clinical features and diagnosis

The deacetylase HDAC6 regulates aggresome formation and cell viability in response to misfolded protein stress

Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

Pre-fibrillar alpha-synuclein variants with impaired beta-structure increase neurotoxicity in Parkinson's disease models

Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

alpha-Synuclein locus triplication causes Parkinson's disease

HDAC6 controls major cell response pathways to cytotoxic accumulation of protein aggregates

Identification and functional characterization of a novel R621C mutation in the synphilin-1 gene in Parkinson's disease

Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death

Mapping of a gene for Parkinson's disease to chromosome 4q21-q23

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13

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21

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2893978

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