The LIM domain gene LMO4 inhibits differentiation of mammary epithelial cells in vitro and is overexpressed in breast cancer. - Wikidata - wikimedia - TriplyDB

The LIM domain gene LMO4 inhibits differentiation of mammary epithelial cells in vitro and is overexpressed in breast cancer.

The LIM domain gene LMO4 inhibits differentiation of mammary epithelial cells in vitro and is overexpressed in breast cancer.

http://www.wikidata.org/entity/Q33951939

about

The LIM domain protein LMO4 interacts with the cofactor CtIP and the tumor suppressor BRCA1 and inhibits BRCA1 activity Functional proteomics mapping of a human signaling pathway Overexpression of LMO4 induces mammary hyperplasia, promotes cell invasion, and is a predictor of poor outcome in breast cancer Regulation of estrogen-dependent transcription by the LIM cofactors CLIM and RLIM in breast cancer Stabilization of a binary protein complex by intein-mediated cyclization Structural basis for the recognition of ldb1 by the N-terminal LIM domains of LMO2 and LMO4 Mutation analysis of FANCD2, BRIP1/BACH1, LMO4 and SFN in familial breast cancer.Conformational flexibility of the oncogenic protein LMO2 primes the formation of the multi-protein transcription complex Null mutation of the Lmo4 gene or a combined null mutation of the Lmo1/Lmo3 genes causes perinatal lethality, and Lmo4 controls neural tube development in mice The ubiquitin ligase Rnf6 regulates local LIM kinase 1 levels in axonal growth cones.Defective neural tube closure and anteroposterior patterning in mice lacking the LIM protein LMO4 or its interacting partner Deaf-1 Drosophila, a genetic model system to study cocaine-related behaviors: a review with focus on LIM-only proteins.Transcriptome analyses of mouse and human mammary cell subpopulations reveal multiple conserved genes and pathways Oncogenic LMO3 collaborates with HEN2 to enhance neuroblastoma cell growth through transactivation of Mash1 Zinc finger protein 185 is a liver metastasis-associated factor in colon cancer patients.The co-factor of LIM domains (CLIM/LDB/NLI) maintains basal mammary epithelial stem cells and promotes breast tumorigenesis.Integrative genomics identifies LMO1 as a neuroblastoma oncogene.Necdin, a p53-target gene, is an inhibitor of p53-mediated growth arrest.Discovery of novel mechanosensitive genes in vivo using mouse carotid artery endothelium exposed to disturbed flow.Contribution of DEAF1 structural domains to the interaction with the breast cancer oncogene LMO4.Insights into gene expression changes impacting B-cell transformation: cross-species microarray analysis of bovine leukemia virus tax-responsive genes in ovine B cells Functional activity of RLIM/Rnf12 is regulated by phosphorylation-dependent nucleocytoplasmic shuttling Fibroblast growth factor receptor signaling dramatically accelerates tumorigenesis and enhances oncoprotein translation in the mouse mammary tumor virus-Wnt-1 mouse model of breast cancer.Gene expression analysis of immune-mediated arrest of tumorigenesis in a transgenic mouse model of HER-2/neu-positive basal-like mammary carcinoma.The structure of an LIM-only protein 4 (LMO4) and Deformed epidermal autoregulatory factor-1 (DEAF1) complex reveals a common mode of binding to LMO4.Stem cells in normal breast development and breast cancer.LIM-domain-binding protein 1: a multifunctional cofactor that interacts with diverse proteins.Single-stranded DNA-binding proteins regulate the abundance of LIM domain and LIM domain-binding proteins.LIM-Only Protein 4 (LMO4) and LIM Domain Binding Protein 1 (LDB1) Promote Growth and Metastasis of Human Head and Neck Cancer (LMO4 and LDB1 in Head and Neck Cancer).Oncogenic Lmo3 cooperates with Hen2 to induce hydrocephalus in mice.Proteomics of TGF-beta signaling and its impact on breast cancer.Expression of LMO4 and outcome in pancreatic ductal adenocarcinoma.Aberrant expression of LMO4 induces centrosome amplification and mitotic spindle abnormalities in breast cancer cells.Drosophila LIM-only is a positive regulator of transcription during thoracic bristle development.LIM only 4 is overexpressed in late stage pancreas cancer Apoptotic cell death in neuroblastoma.LDB1 overexpression is a negative prognostic factor in colorectal cancer.LIM-domain-only proteins in cancer.LIM-domain-only proteins: multifunctional nuclear transcription coregulators that interacts with diverse proteins.The LIM-only factor LMO4 regulates expression of the BMP7 gene through an HDAC2-dependent mechanism, and controls cell proliferation and apoptosis of mammary epithelial cells.

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P2860

The LIM domain gene LMO4 inhibits differentiation of mammary epithelial cells in vitro and is overexpressed in breast cancer.

http://www.wikidata.org/entity/Q33951939

description

2001 nî lūn-bûn

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2001 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

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2001 թվականի դեկտեմբերին հրատարակված գիտական հոդված

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2001年の論文

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2001年論文

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2001年論文

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2001年論文

@zh-hk

2001年論文

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2001年論文

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2001年论文

@wuu

name

The LIM domain gene LMO4 inhib ...... verexpressed in breast cancer.

@ast

The LIM domain gene LMO4 inhib ...... verexpressed in breast cancer.

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type

label

The LIM domain gene LMO4 inhib ...... verexpressed in breast cancer.

@ast

The LIM domain gene LMO4 inhib ...... verexpressed in breast cancer.

@en

prefLabel

The LIM domain gene LMO4 inhib ...... verexpressed in breast cancer.

@ast

The LIM domain gene LMO4 inhib ...... verexpressed in breast cancer.

@en

P1433

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P1433

Proceedings of the National Academy of Sciences of the United States of America

P1476

The LIM domain gene LMO4 inhib ...... overexpressed in breast cancer

@en

P2093

Armes J

http://www.w3.org/2001/XMLSchema#string

Hahm K

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O'Reilly L

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Santamaria M

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Sum EY

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Venter D

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Visvader JE

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White D

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Williams R

http://www.w3.org/2001/XMLSchema#string

P2860

Molecular cloning of LMO41, a new human LIM domain gene

Cloning of a novel nucleolar guanosine 5'-triphosphate binding protein autoantigen from a breast tumor

The LIM-domain binding protein Ldb1 and its partner LMO2 act as negative regulators of erythroid differentiation

TTG-2, a new gene encoding a cysteine-rich protein with the LIM motif, is overexpressed in acute T-cell leukaemia with the t(11;14)(p13;q11)

The rhombotin family of cysteine-rich LIM-domain oncogenes: distinct members are involved in T-cell translocations to human chromosomes 11p15 and 11p13

The mechanism of chromosomal translocation t(11;14) involving the T-cell receptor C delta locus on human chromosome 14q11 and a transcribed region of chromosome 11p15

Detection and mapping of amplified DNA sequences in breast cancer by comparative genomic hybridization

Nuclear LIM interactor, a rhombotin and LIM homeodomain interacting protein, is expressed early in neuronal development

Identification and characterization of LMO4, an LMO gene with a novel pattern of expression during embryogenesis

LIM domains: multiple roles as adapters and functional modifiers in protein interactions

P304

14452-14457

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scholarly article

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10.1073/PNAS.251547698

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25

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98

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Geoffrey J. Lindeman

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2001-12-01T00:00:00Z

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11621041

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11734645

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64702

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