Disruption of the 11-cis-retinol dehydrogenase gene leads to accumulation of cis-retinols and cis-retinyl esters. - Wikidata - wikimedia - TriplyDB

Disruption of the 11-cis-retinol dehydrogenase gene leads to accumulation of cis-retinols and cis-retinyl esters.

Disruption of the 11-cis-retinol dehydrogenase gene leads to accumulation of cis-retinols and cis-retinyl esters.

http://www.wikidata.org/entity/Q33963932

about

Dual-substrate specificity short chain retinol dehydrogenases from the vertebrate retina Characterization of key residues and membrane association domains in retinol dehydrogenase 10 Stimulation of retinoic acid production and growth by ubiquitously expressed alcohol dehydrogenase Adh3 Role of photoreceptor-specific retinol dehydrogenase in the retinoid cycle in vivo.Retinol Dehydrogenases Regulate Vitamin A Metabolism for Visual Function Biosynthesis of 9-cis-retinoic acid in vivo. The roles of different retinol dehydrogenases and a structure-activity analysis of microsomal retinol dehydrogenases RPE65, visual cycle retinol isomerase, is not inherently 11-cis-specific: support for a carbocation mechanism of retinol isomerization Membrane-binding and enzymatic properties of RPE65 Chemistry of the retinoid (visual) cycle Isomerization of 11-cis-retinoids to all-trans-retinoids in vitro and in vivo.Characterization of a dehydrogenase activity responsible for oxidation of 11-cis-retinol in the retinal pigment epithelium of mice with a disrupted RDH5 gene. A model for the human hereditary disease fundus albipunctatus.Localizations of visual cycle components in retinal pigment epithelium Genetic evidence that retinaldehyde dehydrogenase Raldh1 (Aldh1a1) functions downstream of alcohol dehydrogenase Adh1 in metabolism of retinol to retinoic acid Chemistry and biology of the initial steps in vision: the Friedenwald lecture.Distinct retinoid metabolic functions for alcohol dehydrogenase genes Adh1 and Adh4 in protection against vitamin A toxicity or deficiency revealed in double null mutant mice Inhibition of the visual cycle in vivo by 13-cis retinoic acid protects from light damage and provides a mechanism for night blindness in isotretinoin therapy.Retinol dehydrogenase (RDH12) protects photoreceptors from light-induced degeneration in mice.Mutation of key residues of RPE65 abolishes its enzymatic role as isomerohydrolase in the visual cycle.Biochemical defects in 11-cis-retinol dehydrogenase mutants associated with fundus albipunctatus.Retinal degeneration in animal models with a defective visual cycle.Fluorescence adaptive optics scanning laser ophthalmoscope for detection of reduced cones and hypoautofluorescent spots in fundus albipunctatus Delayed dark adaptation in 11-cis-retinol dehydrogenase-deficient mice: a role of RDH11 in visual processes in vivo.Lecithin-retinol acyltransferase is essential for accumulation of all-trans-retinyl esters in the eye and in the liver.Fundus albipunctatus: review of the literature and report of a novel RDH5 gene mutation affecting the invariant tyrosine (p.Tyr175Phe)Understanding retinol metabolism: structure and function of retinol dehydrogenases.Evaluation of the role of the retinal G protein-coupled receptor (RGR) in the vertebrate retina in vivo.Stereoisomeric specificity of the retinoid cycle in the vertebrate retina.The role of 11-cis-retinyl esters in vertebrate cone vision.Treatment with isotretinoin inhibits lipofuscin accumulation in a mouse model of recessive Stargardt's macular degeneration.Aberrant metabolites in mouse models of congenital blinding diseases: formation and storage of retinyl esters.Key enzymes of the retinoid (visual) cycle in vertebrate retina Improvement in rod and cone function in mouse model of Fundus albipunctatus after pharmacologic treatment with 9-cis-retinal.Targeted disruption of the murine retinal dehydrogenase gene Rdh12 does not limit visual cycle function.The specific binding of retinoic acid to RPE65 and approaches to the treatment of macular degeneration.Novel mutations in RDH5 cause fundus albipunctatus in two consanguineous Pakistani families.Leukemia inhibitory factor coordinates the down-regulation of the visual cycle in the retina and retinal-pigmented epithelium.Molecular biology and analytical chemistry methods used to probe the retinoid cycle Visualization of retinoid storage and trafficking by two-photon microscopy.Redundant and unique roles of retinol dehydrogenases in the mouse retina.Diseases caused by defects in the visual cycle: retinoids as potential therapeutic agents

P2860

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P2860

Disruption of the 11-cis-retinol dehydrogenase gene leads to accumulation of cis-retinols and cis-retinyl esters.

http://www.wikidata.org/entity/Q33963932

description

2000 nî lūn-bûn

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2000 թուականի Յունիսին հրատարակուած գիտական յօդուած

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2000 թվականի հունիսին հրատարակված գիտական հոդված

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2000年の論文

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2000年論文

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2000年論文

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2000年論文

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Disruption of the 11-cis-retin ...... tinols and cis-retinyl esters.

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Disruption of the 11-cis-retin ...... tinols and cis-retinyl esters.

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Disruption of the 11-cis-retin ...... tinols and cis-retinyl esters.

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Disruption of the 11-cis-retin ...... tinols and cis-retinyl esters.

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Disruption of the 11-cis-retin ...... tinols and cis-retinyl esters.

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Disruption of the 11-cis-retin ...... tinols and cis-retinyl esters.

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MCB.20.12.4275-4287.2000

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Molecular and Cellular Biology

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Disruption of the 11-cis-retin ...... tinols and cis-retinyl esters.

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P2093

A F Deutman

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A H Van Vugt

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B E Wieringa

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B P Janssen

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C A Driessen

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H J Winkens

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J J Janssen

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J P Van Hooser

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K Hoffmann

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K Palczewski

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P2860

Identification and characterization of a stereospecific human enzyme that catalyzes 9-cis-retinol oxidation. A possible role in 9-cis-retinoic acid formation

Mutations in RPE65 cause autosomal recessive childhood-onset severe retinal dystrophy

Mutation of the gene encoding cellular retinaldehyde-binding protein in autosomal recessive retinitis pigmentosa

Activity of human 11-cis-retinol dehydrogenase (Rdh5) with steroids and retinoids and expression of its mRNA in extra-ocular human tissue

Isomerization of all-trans-retinoids to 11-cis-retinoids in vitro

Mutations in the RPE65 gene in patients with autosomal recessive retinitis pigmentosa or leber congenital amaurosis

Mutations in the gene encoding 11-cis retinol dehydrogenase cause delayed dark adaptation and fundus albipunctatus

Insights into the function of Rim protein in photoreceptors and etiology of Stargardt's disease from the phenotype in abcr knockout mice

Embryonic retinoic acid synthesis is essential for early mouse post-implantation development

Mutations in RPE65 cause Leber's congenital amaurosis

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