ATM-deficient thymic lymphoma is associated with aberrant tcrd rearrangement and gene amplification. - Wikidata - wikimedia - TriplyDB

ATM-deficient thymic lymphoma is associated with aberrant tcrd rearrangement and gene amplification.

ATM-deficient thymic lymphoma is associated with aberrant tcrd rearrangement and gene amplification.

http://www.wikidata.org/entity/Q33979941

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Ataxia telangiectasia: a review ATM limits incorrect end utilization during non-homologous end joining of multiple chromosome breaks RAG2's acidic hinge restricts repair-pathway choice and promotes genomic stability.New diagnosis of atypical ataxia-telangiectasia in a 17-year-old boy with T-cell acute lymphoblastic leukemia and a novel ATM mutation Developmental propagation of V(D)J recombination-associated DNA breaks and translocations in mature B cells via dicentric chromosomes.Mechanisms that can promote peripheral B-cell lymphoma in ATM-deficient mice.Chromosome instability induced by Mps1 and p53 mutation generates aggressive lymphomas exhibiting aneuploidy-induced stress.The RAG2 C terminus suppresses genomic instability and lymphomagenesis.The BCL11B tumor suppressor is mutated across the major molecular subtypes of T-cell acute lymphoblastic leukemia.Aberrant TCRδ rearrangement underlies the T-cell lymphocytopenia and t(12;14) translocation associated with ATM deficiency.Overlapping functions between XLF repair protein and 53BP1 DNA damage response factor in end joining and lymphocyte development Redundant and nonredundant functions of ATM and H2AX in αβ T-lineage lymphocytes.DNA Repair Cofactors ATMIN and NBS1 Are Required to Suppress T Cell Activation.RAG2 and XLF/Cernunnos interplay reveals a novel role for the RAG complex in DNA repair Restoration of ATM Expression in DNA-PKcs-Deficient Cells Inhibits Signal End Joining.Higher-order looping and nuclear organization of Tcra facilitate targeted rag cleavage and regulated rearrangement in recombination centers Kinase-dead ATM protein is highly oncogenic and can be preferentially targeted by Topo-isomerase I inhibitors The RAG2 C-terminus and ATM protect genome integrity by controlling antigen receptor gene cleavage.Gadd45a deletion aggravates hematopoietic stem cell dysfunction in ATM-deficient mice.Nucks1 synergizes with Trp53 to promote radiation lymphomagenesis in mice 53BP1 is limiting for NHEJ repair in ATM-deficient model systems that are subjected to oncogenic stress or radiation.Strain background determines lymphoma incidence in Atm knockout mice The role of mechanistic factors in promoting chromosomal translocations found in lymphoid and other cancers.How does DNA break during chromosomal translocations?Cell cycle regulatory molecular profiles of pediatric T-cell lymphoblastic leukemia and lymphoma.XCIND as a genetic disease of X-irradiation hypersensitivity and cancer susceptibility.Breakpoint sites disclose the role of the V(D)J recombination machinery in the formation of T-cell receptor (TCR) and non-TCR associated aberrations in T-cell acute lymphoblastic leukemia.Multispectral imaging: a review of its technical aspects and applications in anatomic pathology.A new take on v(d)j recombination: transcription driven nuclear and chromatin reorganization in rag-mediated cleavage.Functional overlaps between XLF and the ATM-dependent DNA double strand break response.Programmed DNA breaks in lymphoid cells: repair mechanisms and consequences in human disease Recurrent trisomy and Robertsonian translocation of chromosome 14 in murine iPS cell lines.Tcrδ translocations that delete the Bcl11b haploinsufficient tumor suppressor gene promote atm-deficient T cell acute lymphoblastic leukemia.ATM deficiency augments constitutively nuclear cyclin D1-driven genomic instability and lymphomagenesis.A hypomorphic Artemis human disease allele causes aberrant chromosomal rearrangements and tumorigenesis.Early B-cell-specific inactivation of ATM synergizes with ectopic CyclinD1 expression to promote pre-germinal center B-cell lymphomas in mice.Haploinsufficiency of Bcl11b suppresses the progression of ATM-deficient T cell lymphomas.Somatic inactivation of ATM in hematopoietic cells predisposes mice to cyclin D3 dependent T cell acute lymphoblastic leukemia.Ataxia telangiectasia syndrome: moonlighting ATM.

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ATM-deficient thymic lymphoma is associated with aberrant tcrd rearrangement and gene amplification.

http://www.wikidata.org/entity/Q33979941

description

2010 nî lūn-bûn

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2010 թուականի Յունիսին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի հունիսին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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name

ATM-deficient thymic lymphoma ...... gement and gene amplification.

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ATM-deficient thymic lymphoma ...... gement and gene amplification.

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type

label

ATM-deficient thymic lymphoma ...... gement and gene amplification.

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ATM-deficient thymic lymphoma ...... gement and gene amplification.

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prefLabel

ATM-deficient thymic lymphoma ...... gement and gene amplification.

@ast

ATM-deficient thymic lymphoma ...... gement and gene amplification.

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Journal of Experimental Medicine

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ATM-deficient thymic lymphoma ...... gement and gene amplification.

@en

P2093

A Thomas Look

http://www.w3.org/2001/XMLSchema#string

Craig H Bassing

http://www.w3.org/2001/XMLSchema#string

Frederick W Alt

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Harin Patel

http://www.w3.org/2001/XMLSchema#string

James W Brush

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Michael M Murphy

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Peter H Goff

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Richard A Gatti

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Shan Zha

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Suprawee Tepsuporn

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P2860

Oncogenic transformation in the absence of Xrcc4 targets peripheral B cells that have undergone editing and switching

Molecular analysis of a t(14;14) translocation in leukemic T-cells of an ataxia telangiectasia patient

Molecular basis of mature T-cell leukemia

The mechanism of human nonhomologous DNA end joining

Targeted disruption of ATM leads to growth retardation, chromosomal fragmentation during meiosis, immune defects, and thymic lymphoma

Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia

Circular binary segmentation for the analysis of array-based DNA copy number data

Atm-deficient mice: a paradigm of ataxia telangiectasia

ATM prevents the persistence and propagation of chromosome breaks in lymphocytes.

Mechanisms promoting translocations in editing and switching peripheral B cells.

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1369-1380

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scholarly article

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10.1084/JEM.20100285

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7

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207

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2010-06-21T00:00:00Z

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44691182

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20566716

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