RAG2 and XLF/Cernunnos interplay reveals a novel role for the RAG complex in DNA repair

RAG2 and XLF/Cernunnos interplay reveals a novel role for the RAG complex in DNA repair

Item
http://www.wikidata.org/entity/Q36542548
PAXX and XLF DNA repair factors are functionally redundant in joining DNA breaks in a G1-arrested progenitor B-cell line.Real-time analysis of RAG complex activity in V(D)J recombinationSynthetic lethality between PAXX and XLF in mammalian development.PAXX promotes KU accumulation at DNA breaks and is essential for end-joining in XLF-deficient mice.V(D)J Recombination Exploits DNA Damage Responses to Promote Immunity.Recent advances in the study of immunodeficiency and DNA damage response.XLF deficiency results in reduced N-nucleotide addition during V(D)J recombination.Specific Roles of XRCC4 Paralogs PAXX and XLF during V(D)J Recombination.RAG1/2 induces genomic insertions by mobilizing DNA into RAG1/2-independent breaksDeficiency of XLF and PAXX prevents DNA double-strand break repair by non-homologous end joining in lymphocytes.Generation and CRISPR/Cas9 editing of transformed progenitor B cells as a pseudo-physiological system to study DNA repair gene function in V(D)J recombination.Synthetic lethality between murine DNA repair factors XLF and DNA-PKcs is rescued by inactivation of Ku70.PAXX and Xlf interplay revealed by impaired CNS development and immunodeficiency of double KO mice.Normal development of mice lacking PAXX, the paralogue of XRCC4 and XLF.
P2860

RAG2 and XLF/Cernunnos interplay reveals a novel role for the RAG complex in DNA repair

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http://www.wikidata.org/entity/Q36542548
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2016 nî lūn-bûn
@nan
2016年の論文
@ja
2016年論文
@yue
2016年論文
@zh-hant
2016年論文
@zh-hk
2016年論文
@zh-mo
2016年論文
@zh-tw
2016年论文
@wuu
2016年论文
@zh
2016年论文
@zh-cn
name
RAG2 and XLF/Cernunnos interplay reveals a novel role for the RAG complex in DNA repair
@ast
RAG2 and XLF/Cernunnos interplay reveals a novel role for the RAG complex in DNA repair
@en
type
label
RAG2 and XLF/Cernunnos interplay reveals a novel role for the RAG complex in DNA repair
@ast
RAG2 and XLF/Cernunnos interplay reveals a novel role for the RAG complex in DNA repair
@en
prefLabel
RAG2 and XLF/Cernunnos interplay reveals a novel role for the RAG complex in DNA repair
@ast
RAG2 and XLF/Cernunnos interplay reveals a novel role for the RAG complex in DNA repair
@en
P1433
P1476
P2093
P2860
P2888
P304
P31
P356
P407
P478
P50
P577
P5875
P698
P932
P356
P1433
P1476
RAG2 and XLF/Cernunnos interplay reveals a novel role for the RAG complex in DNA repair
@en
P2093
P2860
P2888
P304
P31
P356
P407
P478
P50
P577
P5875
P698
P932