Mre11 and Rad50 from Pyrococcus furiosus: cloning and biochemical characterization reveal an evolutionarily conserved multiprotein machine.
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An expanded inventory of conserved meiotic genes provides evidence for sex in Trichomonas vaginalisThe Mre11 protein interacts with both Rad50 and the HerA bipolar helicase and is recruited to DNA following gamma irradiation in the archaeon Sulfolobus acidocaldariusGenome analysis and genome-wide proteomics of Thermococcus gammatolerans, the most radioresistant organism known amongst the ArchaeaRAD50 and NBS1 form a stable complex functional in DNA binding and tetheringDNA end resection: many nucleases make light workThe Mre11/Rad50/Nbs1 complex: recent insights into catalytic activities and ATP-driven conformational changesSuperoxide dismutase from the eukaryotic thermophile Alvinella pompejana: structures, stability, mechanism, and insights into amyotrophic lateral sclerosisStructural basis for DNA recognition and nuclease processing by the Mre11 homologue SbcD in double-strand breaks repairAn archaeal Rad54 protein remodels DNA and stimulates DNA strand exchange by RadARAD50, an SMC family member with multiple roles in DNA break repair: how does ATP affect function?Role of RAD52 epistasis group genes in homologous recombination and double-strand break repairIdentification of a novel helicase activity unwinding branched DNAs from the hyperthermophilic archaeon, Pyrococcus furiosus.ATM activation and its recruitment to damaged DNA require binding to the C terminus of Nbs1.End resection at double-strand breaks: mechanism and regulation.MlaA, a hexameric ATPase linked to the Mre11 complex in archaeal genomes.An interaction between the Walker A and D-loop motifs is critical to ATP hydrolysis and cooperativity in bacteriophage T4 Rad50Homologous recombination occurs in Entamoeba and is enhanced during growth stress and stage conversion.Mre11-Rad50-Nbs1 conformations and the control of sensing, signaling, and effector responses at DNA double-strand breaksBiochemical characterization of bacteriophage T4 Mre11-Rad50 complexCrystal structure of the Mre11-Rad50-ATPγS complex: understanding the interplay between Mre11 and Rad50Envisioning the fourth dimension of the genetic code: the structural biology of macromolecular recognition and conformational switching in DNA repair.Biochemical and Functional Characterization of the NurA-HerA Complex from Deinococcus radiodurans.DNA repair factor MRE11/RAD50 cleaves 3'-phosphotyrosyl bonds and resects DNA to repair damage caused by topoisomerase 1 poisons.ATP hydrolysis by RAD50 protein switches MRE11 enzyme from endonuclease to exonuclease.NurA Is Endowed with Endo- and Exonuclease Activities that Are Modulated by HerA: New Insight into Their Role in DNA-End ProcessingATP-dependent DNA binding, unwinding, and resection by the Mre11/Rad50 complexRad50 is not essential for the Mre11-dependent repair of DNA double-strand breaks in Halobacterium sp. strain NRC-1.Mre11-Rad50-Nbs1 is a keystone complex connecting DNA repair machinery, double-strand break signaling, and the chromatin template.Coprinus cinereus rad50 mutants reveal an essential structural role for Rad50 in axial element and synaptonemal complex formation, homolog pairing and meiotic recombinationA 21-amino acid peptide from the cysteine cluster II of the family D DNA polymerase from Pyrococcus horikoshii stimulates its nuclease activity which is Mre11-like and prefers manganese ion as the cofactorA bipolar DNA helicase gene, herA, clusters with rad50, mre11 and nurA genes in thermophilic archaea.Metal dependence and branched RNA cocrystal structures of the RNA lariat debranching enzyme Dbr1.Making the best of the loose ends: Mre11/Rad50 complexes and Sae2 promote DNA double-strand break resection.Structural studies of DNA end detection and resection in homologous recombination.ATP puts the brake on DNA double-strand break repair: a new study shows that ATP switches the Mre11-Rad50-Nbs1 repair factor between signaling and processing of DNA ends.Metallophosphoesterases: structural fidelity with functional promiscuity.CtIP/Ctp1/Sae2, molecular form fit for function.Consider the workhorse: Nonhomologous end-joining in budding yeast.A novel mode of nuclease action is revealed by the bacterial Mre11/Rad50 complex.DNA end-binding specificity of human Rad50/Mre11 is influenced by ATP.
P2860
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P2860
Mre11 and Rad50 from Pyrococcus furiosus: cloning and biochemical characterization reveal an evolutionarily conserved multiprotein machine.
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2000 nî lūn-bûn
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2000 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
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2000 թվականի նոյեմբերին հրատարակված գիտական հոդված
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2000年の論文
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2000年論文
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2000年論文
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Mre11 and Rad50 from Pyrococcu ...... onserved multiprotein machine.
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Mre11 and Rad50 from Pyrococcu ...... onserved multiprotein machine.
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label
Mre11 and Rad50 from Pyrococcu ...... onserved multiprotein machine.
@ast
Mre11 and Rad50 from Pyrococcu ...... onserved multiprotein machine.
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prefLabel
Mre11 and Rad50 from Pyrococcu ...... onserved multiprotein machine.
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Mre11 and Rad50 from Pyrococcu ...... onserved multiprotein machine.
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P2093
P2860
P1476
Mre11 and Rad50 from Pyrococcu ...... onserved multiprotein machine.
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P2093
P2860
P304
P356
10.1128/JB.182.21.6036-6041.2000
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P577
2000-11-01T00:00:00Z