Footprint analysis of the RAG protein recombination signal sequence complex for V(D)J type recombination.
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The RAG1 homeodomain recruits HMG1 and HMG2 to facilitate recombination signal sequence binding and to enhance the intrinsic DNA-bending activity of RAG1-RAG2A functional analysis of the spacer of V(D)J recombination signal sequencesStructure of the RAG1 nonamer binding domain with DNA reveals a dimer that mediates DNA synapsisRecombination-activating gene proteins: more regulation, pleaseThe taming of a transposon: V(D)J recombination and the immune systemDistinct roles of RAG1 and RAG2 in binding the V(D)J recombination signal sequences.RAG-2 promotes heptamer occupancy by RAG-1 in the assembly of a V(D)J initiation complex.Detection of RAG protein-V(D)J recombination signal interactions near the site of DNA cleavage by UV cross-linking.Mutations in conserved regions of the predicted RAG2 kelch repeats block initiation of V(D)J recombination and result in primary immunodeficienciesMutational analysis of all conserved basic amino acids in RAG-1 reveals catalytic, step arrest, and joining-deficient mutants in the V(D)J recombinaseAssembly of the RAG1/RAG2 synaptic complexMutational analysis of RAG1 and RAG2 identifies three catalytic amino acids in RAG1 critical for both cleavage steps of V(D)J recombination.DNA cleavage activity of the V(D)J recombination protein RAG1 is autoregulated.Regulation of T-cell receptor beta-chain gene assembly by recombination signals: the beyond 12/23 restriction.Many levels of control of V gene rearrangement frequency.The bounty of RAGs: recombination signal complexes and reaction outcomes.Sequence of the spacer in the recombination signal sequence affects V(D)J rearrangement frequency and correlates with nonrandom Vkappa usage in vivoA non-sequence-specific DNA binding mode of RAG1 is inhibited by RAG2A zinc site in the C-terminal domain of RAG1 is essential for DNA cleavage activity.Genetic regulation of the yefM-yoeB toxin-antitoxin locus of Streptococcus pneumoniae.RAG1-DNA binding in V(D)J recombination. Specificity and DNA-induced conformational changes revealed by fluorescence and CD spectroscopy.Fine structure and activity of discrete RAG-HMG complexes on V(D)J recombination signals.Footprint analysis of recombination signal sequences in the 12/23 synaptic complex of V(D)J recombination.RAG-heptamer interaction in the synaptic complex is a crucial biochemical checkpoint for the 12/23 recombination rule.Joining mutants of RAG1 and RAG2 that demonstrate impaired interactions with the coding-end DNA.In vitro processing of the 3'-overhanging DNA in the postcleavage complex involved in V(D)J joining.The effect of Me2+ cofactors at the initial stages of V(D)J recombination.Recombination activating genes (RAG) induce secondary Ig gene rearrangement in and subsequent apoptosis of human peripheral blood circulating B lymphocytes.
P2860
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P2860
Footprint analysis of the RAG protein recombination signal sequence complex for V(D)J type recombination.
description
1998 nî lūn-bûn
@nan
1998 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի հունվարին հրատարակված գիտական հոդված
@hy
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
name
Footprint analysis of the RAG ...... for V(D)J type recombination.
@ast
Footprint analysis of the RAG ...... for V(D)J type recombination.
@en
type
label
Footprint analysis of the RAG ...... for V(D)J type recombination.
@ast
Footprint analysis of the RAG ...... for V(D)J type recombination.
@en
prefLabel
Footprint analysis of the RAG ...... for V(D)J type recombination.
@ast
Footprint analysis of the RAG ...... for V(D)J type recombination.
@en
P2093
P2860
P356
P1476
Footprint analysis of the RAG ...... x for V(D)J type recombination
@en
P2093
A Ishikawa
A J Otsuka
K Ishiguro
T Takemori
P2860
P304
P356
10.1128/MCB.18.1.655
P407
P50
P577
1998-01-01T00:00:00Z