Neurotoxic effects of TDP-43 overexpression in C. elegans.
about
Conjoint pathologic cascades mediated by ALS/FTLD-U linked RNA-binding proteins TDP-43 and FUSFrom animal models to human disease: a genetic approach for personalized medicine in ALSUsing C. elegans to discover therapeutic compounds for ageing-associated neurodegenerative diseasesYeast prions and human prion-like proteins: sequence features and prediction methodsDoes a loss of TDP-43 function cause neurodegeneration?Mutant TDP-43 and FUS cause age-dependent paralysis and neurodegeneration in C. elegansRNA-processing protein TDP-43 regulates FOXO-dependent protein quality control in stress responseTDP-1/TDP-43 regulates stress signaling and age-dependent proteotoxicity in Caenorhabditis elegansThe struggle by Caenorhabditis elegans to maintain proteostasis during aging and diseaseMechanisms of aging-related proteinopathies in Caenorhabditis elegansTDP-43 Proteinopathy and ALS: Insights into Disease Mechanisms and Therapeutic Targets.Aberrant localization of FUS and TDP43 is associated with misfolding of SOD1 in amyotrophic lateral sclerosisNon-human primate model of amyotrophic lateral sclerosis with cytoplasmic mislocalization of TDP-43ALS-linked TDP-43 mutations produce aberrant RNA splicing and adult-onset motor neuron disease without aggregation or loss of nuclear TDP-43.Protein kinase CK-1 inhibitors as new potential drugs for amyotrophic lateral sclerosis.Expression of ALS-linked TDP-43 mutant in astrocytes causes non-cell-autonomous motor neuron death in ratsLoss of function CHCHD10 mutations in cytoplasmic TDP-43 accumulation and synaptic integrityTDP-43 regulates its mRNA levels through a negative feedback loop.Molecular determinants and genetic modifiers of aggregation and toxicity for the ALS disease protein FUS/TLSNuclear TAR DNA-binding protein 43: A new target for amyotrophic lateral sclerosis treatmentD-beta-hydroxybutyrate extends lifespan in C. elegans.The tip of the iceberg: RNA-binding proteins with prion-like domains in neurodegenerative disease.Coaggregation of RNA-binding proteins in a model of TDP-43 proteinopathy with selective RGG motif methylation and a role for RRM1 ubiquitinationConserved acidic amino acid residues in a second RNA recognition motif regulate assembly and function of TDP-43.TDP-43 in aging and Alzheimer's disease - a reviewTDP-1, the Caenorhabditis elegans ortholog of TDP-43, limits the accumulation of double-stranded RNA.TDP-43 neurotoxicity and protein aggregation modulated by heat shock factor and insulin/IGF-1 signalingOpposing roles of p38 and JNK in a Drosophila model of TDP-43 proteinopathy reveal oxidative stress and innate immunity as pathogenic components of neurodegeneration.Model systems of motor neuron diseases as a platform for studying pathogenic mechanisms and searching for therapeutic agents.TDP-43-based animal models of neurodegeneration: new insights into ALS pathology and pathophysiology.Understanding the role of TDP-43 and FUS/TLS in ALS and beyond.Different 8-hydroxyquinolines protect models of TDP-43 protein, α-synuclein, and polyglutamine proteotoxicity through distinct mechanisms.Caenorhabditis elegans RNA-processing protein TDP-1 regulates protein homeostasis and life spanMotor neuron apoptosis and neuromuscular junction perturbation are prominent features in a Drosophila model of Fus-mediated ALSAn ALS-associated mutation affecting TDP-43 enhances protein aggregation, fibril formation and neurotoxicityActivation of ER Stress and Autophagy Induced by TDP-43 A315T as Pathogenic Mechanism and the Corresponding Histological Changes in Skin as Potential Biomarker for ALS with the MutationCytoplasmic mislocalization of RNA splicing factors and aberrant neuronal gene splicing in TDP-43 transgenic pig brain.Retrotransposon activation contributes to neurodegeneration in a Drosophila TDP-43 model of ALSNeurodegeneration the RNA wayAberrant assembly of RNA recognition motif 1 links to pathogenic conversion of TAR DNA-binding protein of 43 kDa (TDP-43)
P2860
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P2860
Neurotoxic effects of TDP-43 overexpression in C. elegans.
description
2010 nî lūn-bûn
@nan
2010 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Neurotoxic effects of TDP-43 overexpression in C. elegans.
@ast
Neurotoxic effects of TDP-43 overexpression in C. elegans.
@en
Neurotoxic effects of TDP-43 overexpression in C. elegans.
@nl
type
label
Neurotoxic effects of TDP-43 overexpression in C. elegans.
@ast
Neurotoxic effects of TDP-43 overexpression in C. elegans.
@en
Neurotoxic effects of TDP-43 overexpression in C. elegans.
@nl
prefLabel
Neurotoxic effects of TDP-43 overexpression in C. elegans.
@ast
Neurotoxic effects of TDP-43 overexpression in C. elegans.
@en
Neurotoxic effects of TDP-43 overexpression in C. elegans.
@nl
P2093
P2860
P50
P921
P356
P1476
Neurotoxic effects of TDP-43 overexpression in C. elegans.
@en
P2093
Christine M Roberts
Christopher D Link
Peter E A Ash
Tassa Saldi
Yong-Jie Zhang
P2860
P304
P356
10.1093/HMG/DDQ230
P577
2010-06-08T00:00:00Z