about
Structural conservation of druggable hot spots in protein-protein interfacesDruggability Assessment of Allosteric Proteins by Dynamics Simulations in the Presence of Probe MoleculesPRECISE: a Database of Predicted and Consensus Interaction Sites in EnzymesProtein flexibility in docking and surface mappingExpanding the number of 'druggable' targets: non-enzymes and protein-protein interactionsExperimental and computational mapping of the binding surface of a crystalline proteinMinimal Pharmacophoric Elements and Fragment Hopping, an Approach Directed at Molecular Diversity and Isozyme Selectivity. Design of Selective Neuronal Nitric Oxide Synthase InhibitorsDocking for fragment inhibitors of AmpC -lactamaseExperimental and computational active site mapping as a starting point to fragment-based lead discoveryThe crystal structure of subtilisin Carlsberg in anhydrous dioxane and its comparison with those in water and acetonitrileProbing the surface of a sweet protein: NMR study of MNEI with a paramagnetic probeEvidence of conformational selection driving the formation of ligand binding sites in protein-protein interfacesEmerging Computational Methods for the Rational Discovery of Allosteric Drugs.Analysis of protein hydration in ultrahigh-resolution structures of the SRP GTPase FfhEfficient identification of critical residues based only on protein structure by network analysis.Parameter choice matters: validating probe parameters for use in mixed-solvent simulations.Novel druggable hot spots in avian influenza neuraminidase H5N1 revealed by computational solvent mapping of a reduced and representative receptor ensemble.Ensemble-based virtual screening reveals potential novel antiviral compounds for avian influenza neuraminidase.Analysis of substructural variation in families of enzymatic proteins with applications to protein function prediction.Full protein flexibility is essential for proper hot-spot mapping.Anatomy of protein pockets and cavities: measurement of binding site geometry and implications for ligand designNMR studies of protein surface accessibility.Selective prediction of interaction sites in protein structures with THEMATICS.Fragment-based identification of druggable 'hot spots' of proteins using Fourier domain correlation techniques.Detection of ligand binding hot spots on protein surfaces via fragment-based methods: application to DJ-1 and glucocerebrosidase.Pharmacological chaperones stabilize retromer to limit APP processing.Computational mapping identifies the binding sites of organic solvents on proteins.Mapping the druggable allosteric space of G-protein coupled receptors: a fragment-based molecular dynamics approach.Where does amantadine bind to the influenza virus M2 proton channel?Robust identification of binding hot spots using continuum electrostatics: application to hen egg-white lysozyme.Pharmacological chaperones in the age of proteomic pathology.Arbitrary protein-protein docking targets biologically relevant interfaces.FTMAP: extended protein mapping with user-selected probe molecules.Optimal clustering for detecting near-native conformations in protein docking.Improving protocols for protein mapping through proper comparison to crystallography data.FTFlex: accounting for binding site flexibility to improve fragment-based identification of druggable hot spots.Identification of novel drug scaffolds for inhibition of SARS-CoV 3-Chymotrypsin-like protease using virtual and high-throughput screeningsHalogen-enriched fragment libraries as chemical probes for harnessing halogen bonding in fragment-based lead discovery.Evolutionary origins of the estrogen signaling system: insights from amphioxusLigand deconstruction: Why some fragment binding positions are conserved and others are not
P2860
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P2860
description
1996 nî lūn-bûn
@nan
1996 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
1996 թվականի մայիսին հրատարակված գիտական հոդված
@hy
1996年の論文
@ja
1996年論文
@yue
1996年論文
@zh-hant
1996年論文
@zh-hk
1996年論文
@zh-mo
1996年論文
@zh-tw
1996年论文
@wuu
name
Locating and characterizing binding sites on proteins.
@ast
Locating and characterizing binding sites on proteins.
@en
Locating and characterizing binding sites on proteins.
@nl
type
label
Locating and characterizing binding sites on proteins.
@ast
Locating and characterizing binding sites on proteins.
@en
Locating and characterizing binding sites on proteins.
@nl
prefLabel
Locating and characterizing binding sites on proteins.
@ast
Locating and characterizing binding sites on proteins.
@en
Locating and characterizing binding sites on proteins.
@nl
P2860
P356
P1433
P1476
Locating and characterizing binding sites on proteins.
@en
P2093
P2860
P2888
P304
P356
10.1038/NBT0596-595
P577
1996-05-01T00:00:00Z
P5875
P6179
1052333194