Phenotype-based identification of mouse chromosome instability mutants
about
POLQ (Pol theta), a DNA polymerase and DNA-dependent ATPase in human cellsPromiscuous DNA synthesis by human DNA polymerase θHuman DNA polymerase theta possesses 5'-dRP lyase activity and functions in single-nucleotide base excision repair in vitroThe translesion DNA polymerase theta plays a dominant role in immunoglobulin gene somatic hypermutationHigh-efficiency bypass of DNA damage by human DNA polymerase QHigh throughput sequencing approaches to mutation discovery in the mouseMammalian BTBD12 (SLX4) protects against genomic instability during mammalian spermatogenesisDNA polymerase θ (POLQ), double-strand break repair, and cancerDNA Polymerase θ: A Unique Multifunctional End-Joining MachineDNA polymerase theta contributes to the generation of C/G mutations during somatic hypermutation of Ig genes.Mechanism of suppression of chromosomal instability by DNA polymerase POLQMcph1-deficient mice reveal a role for MCPH1 in otitis mediaThe mouse genomic instability mutation chaos1 is an allele of Polq that exhibits genetic interaction with AtmMammalian polymerase θ promotes alternative NHEJ and suppresses recombinationRandom mutagenesis of proximal mouse chromosome 5 uncovers predominantly embryonic lethal mutationsArabidopsis TEBICHI, with helicase and DNA polymerase domains, is required for regulated cell division and differentiation in meristems.A link among DNA replication, recombination, and gene expression revealed by genetic and genomic analysis of TEBICHI gene of Arabidopsis thaliana.High resolution mapping and positional cloning of ENU-induced mutations in the Rw region of mouse chromosome 5.New genetic resources for mammalian developmental biologistsAnalysis of DNA polymerase ν function in meiotic recombination, immunoglobulin class-switching, and DNA damage tolerance.Hypersensitivity of primordial germ cells to compromised replication-associated DNA repair involves ATM-p53-p21 signalingReplication stress induces micronuclei comprising of aggregated DNA double-strand breaksN-ethyl-N-nitrosourea mutagenesis: boarding the mouse mutant express.ENU Mutagenesis in the Mouse.DNA polymerase theta up-regulation is associated with poor survival in breast cancer, perturbs DNA replication, and promotes genetic instabilityMus308 processes oxygen and nitrogen ethylation DNA damage in germ cells of Drosophila.DNA polymerases and somatic hypermutation of immunoglobulin genesLesion bypass activity of DNA polymerase θ (POLQ) is an intrinsic property of the pol domain and depends on unique sequence inserts.Zebrafish genomic instability mutants and cancer susceptibility.Human DNA polymerase θ grasps the primer terminus to mediate DNA repairHaving a direct look: analysis of DNA damage and repair mechanisms by next generation sequencing.Vertebrate POLQ and POLbeta cooperate in base excision repair of oxidative DNA damage.Polymerase Θ is a key driver of genome evolution and of CRISPR/Cas9-mediated mutagenesisDisease severity in a mouse model of ataxia telangiectasia is modulated by the DNA damage checkpoint gene Hus1DNA lesions and repair in immunoglobulin class switch recombination and somatic hypermutation.Linking DNA polymerase theta structure and function in health and diseaseDNA polymerase POLQ and cellular defense against DNA damage.A high-throughput in vivo micronucleus assay for genome instability screening in miceLow-fidelity DNA synthesis by human DNA polymerase theta.DNA polymerases and cancer.
P2860
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P2860
Phenotype-based identification of mouse chromosome instability mutants
description
2003 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի մարտին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2003
@ast
im März 2003 veröffentlichter wissenschaftlicher Artikel
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scientific journal article
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vedecký článok (publikovaný 2003/03/01)
@sk
vědecký článek publikovaný v roce 2003
@cs
wetenschappelijk artikel (gepubliceerd op 2003/03/01)
@nl
наукова стаття, опублікована в березні 2003
@uk
مقالة علمية (نشرت في مارس 2003)
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name
Phenotype-based identification of mouse chromosome instability mutants
@ast
Phenotype-based identification of mouse chromosome instability mutants
@en
Phenotype-based identification of mouse chromosome instability mutants
@nl
type
label
Phenotype-based identification of mouse chromosome instability mutants
@ast
Phenotype-based identification of mouse chromosome instability mutants
@en
Phenotype-based identification of mouse chromosome instability mutants
@nl
prefLabel
Phenotype-based identification of mouse chromosome instability mutants
@ast
Phenotype-based identification of mouse chromosome instability mutants
@en
Phenotype-based identification of mouse chromosome instability mutants
@nl
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P2860
P3181
P1433
P1476
Phenotype-based identification of mouse chromosome instability mutants
@en
P2093
John C. Schimenti
Kerry J. Schimenti
Lawriston A. Wilson
Naoko Shima
Suzanne A. Hartford
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P304
P3181
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2003-03-01T00:00:00Z