Highly organized but pliant active site of DNA polymerase beta: compensatory mechanisms in mutant enzymes revealed by dynamics simulations and energy analyses.
about
Unfavorable Electrostatic and Steric Interactions in DNA Polymerase β E295K Mutant Interfere with the Enzyme’s PathwayRegulation of DNA repair fidelity by molecular checkpoints: "gates" in DNA polymerase beta's substrate selectionUltrafast water dynamics at the interface of the polymerase-DNA binding complexIn silico studies of the African swine fever virus DNA polymerase X support an induced-fit mechanismSubstrate-induced DNA polymerase β activation.Energy analysis of chemistry for correct insertion by DNA polymerase beta.Sequential side-chain residue motions transform the binary into the ternary state of DNA polymerase lambda.Prechemistry versus preorganization in DNA replication fidelity.Differing conformational pathways before and after chemistry for insertion of dATP versus dCTP opposite 8-oxoG in DNA polymerase betaMagnesium-cationic dummy atom molecules enhance representation of DNA polymerase beta in molecular dynamics simulations: improved accuracy in studies of structural features and mutational effects.Polymerase-catalyzed synthesis of DNA from phosphoramidate conjugates of deoxynucleotides and amino acids.The X family portrait: structural insights into biological functions of X family polymerases.Exploring the role of large conformational changes in the fidelity of DNA polymerase betaPerspective: pre-chemistry conformational changes in DNA polymerase mechanismsHow DNA polymerase X preferentially accommodates incoming dATP opposite 8-oxoguanine on the template.Catalytic effects of mutations of distant protein residues in human DNA polymerase β: theory and experiment.Why nature really chose phosphate.Exploring the mechanism of DNA polymerases by analyzing the effect of mutations of active site acidic groups in Polymerase βC(α) torsion angles as a flexible criterion to extract secrets from a molecular dynamics simulation.Fidelity discrimination in DNA polymerase beta: differing closing profiles for a mismatched (G:A) versus matched (G:C) base pair.Influence of DNA structure on DNA polymerase beta active site function: extension of mutagenic DNA intermediates.3-Phosphono-L-alanine as pyrophosphate mimic for DNA synthesis using HIV-1 reverse transcriptase.I260Q DNA polymerase β highlights precatalytic conformational rearrangements critical for fidelity
P2860
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P2860
Highly organized but pliant active site of DNA polymerase beta: compensatory mechanisms in mutant enzymes revealed by dynamics simulations and energy analyses.
description
2004 nî lūn-bûn
@nan
2004 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
Highly organized but pliant ac ...... mulations and energy analyses.
@ast
Highly organized but pliant ac ...... mulations and energy analyses.
@en
Highly organized but pliant ac ...... mulations and energy analyses.
@nl
type
label
Highly organized but pliant ac ...... mulations and energy analyses.
@ast
Highly organized but pliant ac ...... mulations and energy analyses.
@en
Highly organized but pliant ac ...... mulations and energy analyses.
@nl
prefLabel
Highly organized but pliant ac ...... mulations and energy analyses.
@ast
Highly organized but pliant ac ...... mulations and energy analyses.
@en
Highly organized but pliant ac ...... mulations and energy analyses.
@nl
P2093
P2860
P1433
P1476
Highly organized but pliant ac ...... imulations and energy analyses
@en
P2093
Linjing Yang
Suse Broyde
Tamar Schlick
William A Beard
P2860
P304
P356
10.1529/BIOPHYSJ.103.036012
P407
P577
2004-06-01T00:00:00Z