Plasminogen activator inhibitor-1 is a critical downstream target of p53 in the induction of replicative senescence
about
Both telomeric and non-telomeric DNA damage are determinants of mammalian cellular senescenceThe corepressor CTBP2 is a coactivator of retinoic acid receptor/retinoid X receptor in retinoic acid signalingSerine/threonine kinase 17A is a novel p53 target gene and modulator of cisplatin toxicity and reactive oxygen species in testicular cancer cellsYPEL3, a p53-regulated gene that induces cellular senescenceAutophagy mediates the mitotic senescence transitionCellular senescence controls fibrosis in wound healingThe matricellular protein CCN1 induces fibroblast senescence and restricts fibrosis in cutaneous wound healingNutlin-3a activates p53 to both down-regulate inhibitor of growth 2 and up-regulate mir-34a, mir-34b, and mir-34c expression, and induce senescenceEarly embryonic lethality of mice lacking the essential protein SNEVDNA Damage: A Main Determinant of Vascular AgingMolecular turnover, the H3.3 dilemma and organismal aging (hypothesis)Roles and mechanisms of cellular senescence in regulation of tissue homeostasisTumor suppressor p53 and its gain-of-function mutants in cancerNF-κB in cellular senescence and cancer treatmentP53 mutations in colorectal cancer - molecular pathogenesis and pharmacological reactivationTGF-β signaling in tissue fibrosis: redox controls, target genes and therapeutic opportunitiesOf flies, mice, and men: evolutionarily conserved tissue damage responses and agingAberrant autolysosomal regulation is linked to the induction of embryonic senescence: differential roles of Beclin 1 and p53 in vertebrate Spns1 deficiencyAblation of PRMT6 reveals a role as a negative transcriptional regulator of the p53 tumor suppressorEsophageal cancer-related gene 4 is a secreted inducer of cell senescence expressed by aged CNS precursor cellsLoss of the Birt-Hogg-Dubé tumor suppressor results in apoptotic resistance due to aberrant TGFβ-mediated transcriptionSenescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressorThe senescence-associated secretory phenotype: the dark side of tumor suppressionuPA/uPAR and SERPINE1 in head and neck cancer: role in tumor resistance, metastasis, prognosis and therapy.Granule exocytosis mediates immune surveillance of senescent cells.A human-like senescence-associated secretory phenotype is conserved in mouse cells dependent on physiological oxygen.p53 isoforms Delta133p53 and p53beta are endogenous regulators of replicative cellular senescencePAI-1-regulated extracellular proteolysis governs senescence and survival in Klotho mice.Ionizing radiation reduces ADAM10 expression in brain microvascular endothelial cells undergoing stress-induced senescence.PAI-1 Regulates the Invasive Phenotype in Human Cutaneous Squamous Cell Carcinoma.Redox control of p53 in the transcriptional regulation of TGF-β1 target genes through SMAD cooperativity.MiR-125b Is Critical for Fibroblast-to-Myofibroblast Transition and Cardiac Fibrosis.Tumor suppression by p53: making cells senescent.cGAS is essential for cellular senescence.Plasminogen activator inhibitor-1 is an aggregate response factor with pleiotropic effects on cell signaling in vascular disease and the tumor microenvironment.Iscador Qu inhibits doxorubicin-induced senescence of MCF7 cellsp53-mediated hematopoietic stem and progenitor cell competition.BRAF activation induces transformation and then senescence in human neural stem cells: a pilocytic astrocytoma model.Cellular senescence and protein degradation: breaking down cancerMolecular insights into reprogramming-initiation events mediated by the OSKM gene regulatory network.
P2860
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P2860
Plasminogen activator inhibitor-1 is a critical downstream target of p53 in the induction of replicative senescence
description
2006 nî lūn-bûn
@nan
2006 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
Plasminogen activator inhibito ...... tion of replicative senescence
@ast
Plasminogen activator inhibito ...... tion of replicative senescence
@en
Plasminogen activator inhibito ...... tion of replicative senescence
@nl
type
label
Plasminogen activator inhibito ...... tion of replicative senescence
@ast
Plasminogen activator inhibito ...... tion of replicative senescence
@en
Plasminogen activator inhibito ...... tion of replicative senescence
@nl
prefLabel
Plasminogen activator inhibito ...... tion of replicative senescence
@ast
Plasminogen activator inhibito ...... tion of replicative senescence
@en
Plasminogen activator inhibito ...... tion of replicative senescence
@nl
P2860
P356
P1433
P1476
Plasminogen activator inhibito ...... tion of replicative senescence
@en
P2093
Paul J Higgins
Roderik M Kortlever
P2860
P2888
P304
P356
10.1038/NCB1448
P577
2006-07-23T00:00:00Z
P5875
P6179
1041572819