Mouse model for noninvasive imaging of HIF prolyl hydroxylase activity: assessment of an oral agent that stimulates erythropoietin production - Wikidata - wikimedia - TriplyDB

Mouse model for noninvasive imaging of HIF prolyl hydroxylase activity: assessment of an oral agent that stimulates erythropoietin production

Mouse model for noninvasive imaging of HIF prolyl hydroxylase activity: assessment of an oral agent that stimulates erythropoietin production

http://www.wikidata.org/entity/Q34248310

about

HIF prolyl hydroxylase inhibition results in endogenous erythropoietin induction, erythrocytosis, and modest fetal hemoglobin expression in rhesus macaques Oxygen Sensing and Homeostasis In vivo models of brain tumors: roles of genetically engineered mouse models in understanding tumor biology and use in preclinical studies Hypoxia and fibrosis in chronic kidney disease: crossing at pericytes The hypoxia-inducible factor pathway, prolyl hydroxylase domain protein inhibitors, and their roles in bone repair and regeneration HIF hydroxylase pathways in cardiovascular physiology and medicine Attenuating myocardial ischemia by targeting A2B adenosine receptors HIF1A reduces acute lung injury by optimizing carbohydrate metabolism in the alveolar epithelium Frequently asked questions in hypoxia research The myeloma drug lenalidomide promotes the cereblon-dependent destruction of Ikaros proteins Whole animal imaging.Molecular imaging agents: impact on diagnosis and therapeutics in oncology Increased prolyl 4-hydroxylase domain proteins compensate for decreased oxygen levels. Evidence for an autoregulatory oxygen-sensing system.Real-time imaging of HIF-1alpha stabilization and degradation.Anthracyclines suppress pheochromocytoma cell characteristics, including metastasis, through inhibition of the hypoxia signaling pathway.Mechanisms of metabolic memory and renal hypoxia as a therapeutic target in diabetic kidney disease.Suppression of hypoxia-inducible factor 1α (HIF-1α) by tirapazamine is dependent on eIF2α phosphorylation rather than the mTORC1/4E-BP1 pathway.Regulation of 4E-BP1 activity in the mammalian oocyte.Zinc downregulates HIF-1α and inhibits its activity in tumor cells in vitro and in vivo In vivo dynamics and distinct functions of hypoxia in primary tumor growth and organotropic metastasis of breast cancer.Use of the ODD-luciferase transgene for the non-invasive imaging of spontaneous tumors in mice.Development of Neh2-luciferase reporter and its application for high throughput screening and real-time monitoring of Nrf2 activators.Detection of the onset of ischemia and carcinogenesis by hypoxia-inducible transcription factor-based in vivo bioluminescence imaging Assessment of hypoxia inducible factor levels in cancer cell lines upon hypoxic induction using a novel reporter construct Noninvasive imaging of lipid nanoparticle-mediated systemic delivery of small-interfering RNA to the liver.Adora2b-elicited Per2 stabilization promotes a HIF-dependent metabolic switch crucial for myocardial adaptation to ischemia.Generation of a new bioluminescent model for visualisation of mammary tumour development in transgenic mice.Monitoring tumorigenesis and senescence in vivo with a p16(INK4a)-luciferase model.Inhibition of prolyl hydroxylases increases erythropoietin production in ESRD.Drug-induced regeneration in adult mice.Dynamics of tumor hypoxia in response to patupilone and ionizing radiation Optical imaging in vivo with a focus on paediatric disease: technical progress, current preclinical and clinical applications and future perspectives Intermediary metabolite precursor dimethyl-2-ketoglutarate stabilizes hypoxia-inducible factor-1α by inhibiting prolyl-4-hydroxylase PHD2.Erythropoietin after a century of research: younger than ever.Antihelminthic benzimidazoles are novel HIF activators that prevent oxidative neuronal death via binding to tubulin.Regulation of p53 by jagged1 contributes to angiotensin II-induced impairment of myocardial angiogenesis.Applications of molecular imaging.Molecular imaging in tumor angiogenesis and relevant drug research Loss of the retinoblastoma binding protein 2 (RBP2) histone demethylase suppresses tumorigenesis in mice lacking Rb1 or Men1 Enhanced hypoxia-inducible factor (HIF)-1α stability induced by 5-hydroxymethyl-2-furfural (5-HMF) contributes to protection against hypoxia.

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P2860

Mouse model for noninvasive imaging of HIF prolyl hydroxylase activity: assessment of an oral agent that stimulates erythropoietin production

http://www.wikidata.org/entity/Q34248310

description

2005 nî lūn-bûn

@nan

2005 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2005 թվականի դեկտեմբերին հրատարակված գիտական հոդված

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2005年の論文

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2005年論文

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2005年論文

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2005年論文

@zh-hk

2005年論文

@zh-mo

2005年論文

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2005年论文

@wuu

name

Mouse model for noninvasive im ...... ates erythropoietin production

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Mouse model for noninvasive im ...... ates erythropoietin production

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Mouse model for noninvasive im ...... ates erythropoietin production

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type

label

Mouse model for noninvasive im ...... ates erythropoietin production

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Mouse model for noninvasive im ...... ates erythropoietin production

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Mouse model for noninvasive im ...... ates erythropoietin production

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prefLabel

Mouse model for noninvasive im ...... ates erythropoietin production

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Mouse model for noninvasive im ...... ates erythropoietin production

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Mouse model for noninvasive im ...... ates erythropoietin production

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PNAS.0509459103

P1433

Proceedings of the National Academy of Sciences of the United States of America

P1476

Mouse model for noninvasive im ...... ates erythropoietin production

@en

P2093

Fionnuala O'Connell

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James W Horner

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Lee Flippin

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Michal Safran

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Ronald A Depinho

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Volkmar Günzler

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William Y Kim

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P2860

Structure of the VHL-ElonginC-ElonginB complex: implications for VHL tumor suppressor function

HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing

Biochemical purification and pharmacological inhibition of a mammalian prolyl hydroxylase acting on hypoxia-inducible factor.

Regulation of hypoxia-inducible factor 1alpha is mediated by an O2-dependent degradation domain via the ubiquitin-proteasome pathway

The DNA-repair protein AlkB, EGL-9, and leprecan define new families of 2-oxoglutarate- and iron-dependent dioxygenases

Cre reporter strains produced by targeted insertion of EYFP and ECFP into the ROSA26 locus

Generalized lacZ expression with the ROSA26 Cre reporter strain

Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation

Characterization of the human prolyl 4-hydroxylases that modify the hypoxia-inducible factor

Characterization and comparative analysis of the EGLN gene family

P304

105-110

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scholarly article

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10.1073/PNAS.0509459103

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1

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103

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William G. Kaelin

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2005-12-22T00:00:00Z

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7396762

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16373502

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1324998

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