Nef protein of human immunodeficiency virus type 1: evidence against its role as a transcriptional inhibitor.
about
Human immunodeficiency virus type 1 Nef binds directly to Lck and mitogen-activated protein kinase, inhibiting kinase activityBinding of c-Raf1 kinase to a conserved acidic sequence within the carboxyl-terminal region of the HIV-1 Nef proteinHuman immunodeficiency virus type 1 Nef associates with a cellular serine kinase in T lymphocytesPathogenesis of human immunodeficiency virus infectionHuman immunodeficiency virus type 1 Nef associates with a member of the p21-activated kinase familyA novel human immunodeficiency virus type 1 protein, tev, shares sequences with tat, env, and rev proteinsRegions of human immunodeficiency virus type 1 nef required for function in vivoPhysical and functional interaction of Nef with Lck. HIV-1 Nef-induced T-cell signaling defects.Dissociation of the CD4 downregulation and viral infectivity enhancement functions of human immunodeficiency virus type 1 Nef.Human immunodeficiency virus type 1 Nef protein inhibits NF-kappa B induction in human T cells.The human immunodeficiency virus type 2 vpr gene is essential for productive infection of human macrophages.Human immunodeficiency virus type 1 nef quasispecies in pathological tissueThe nef gene of simian immunodeficiency virus SIVmac1A11Positive and negative aspects of the human immunodeficiency virus protease: development of inhibitors versus its role in AIDS pathogenesisThe Vpu protein: new concepts in virus release and CD4 down-modulationAltered T cell activation and development in transgenic mice expressing the HIV-1 nef geneCD4 cell surface downregulation in HIV-1 Nef transgenic mice is a consequence of intracellular sequestration.Feedback regulation of human immunodeficiency virus type 1 expression by the Rev protein.Lack of a negative influence on viral growth by the nef gene of human immunodeficiency virus type 1.Mechanism of action of regulatory proteins encoded by complex retrovirusesCharacterization of nef sequences in long-term survivors of human immunodeficiency virus type 1 infection.Replication in vitro and in vivo of an equine infectious anemia virus mutant deficient in dUTPase activity.Nef stimulates human immunodeficiency virus type 1 proviral DNA synthesisInducible human immunodeficiency virus type 1 packaging cell linesDownregulation of cell-surface CD4 expression by simian immunodeficiency virus Nef prevents viral super infection.The human immunodeficiency virus-1 nef gene product: a positive factor for viral infection and replication in primary lymphocytes and macrophages.Severe immunodeficiency associated with a human immunodeficiency virus 1 NEF/3'-long terminal repeat transgeneCD4 down-regulation by nef alleles isolated from human immunodeficiency virus type 1-infected individuals.Novel features of retroviruses associated with human diseases.Temporal patterns of human immunodeficiency virus type 1 transcripts in human fetal astrocytes.Human immunodeficiency virus type 1 Nef-induced down-modulation of CD4 is due to rapid internalization and degradation of surface CD4.Upstream U3 sequences in simian immunodeficiency virus are selectively deleted in vivo in the absence of an intact nef gene.Optimal infectivity in vitro of human immunodeficiency virus type 1 requires an intact nef gene.Requirement of human immunodeficiency virus type 1 nef for in vivo replication and pathogenicity.Molecular biology of the human immunodeficiency virus accessory proteinsHuman immunodeficiency virus type 1 infection of the brain.The negative effect of human immunodeficiency virus type 1 Nef on cell surface CD4 expression is not species specific and requires the cytoplasmic domain of CD4.Nef from primary isolates of human immunodeficiency virus type 1 suppresses surface CD4 expression in human and mouse T cells.Alternative splicing of human immunodeficiency virus type 1 mRNA modulates viral protein expression, replication, and infectivity.Effects of the tat and nef gene products of human immunodeficiency virus type 1 (HIV-1) on transcription controlled by the HIV-1 long terminal repeat and on cell growth in macrophages
P2860
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P2860
Nef protein of human immunodeficiency virus type 1: evidence against its role as a transcriptional inhibitor.
description
1989 nî lūn-bûn
@nan
1989 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1989 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
1989年の論文
@ja
1989年論文
@yue
1989年論文
@zh-hant
1989年論文
@zh-hk
1989年論文
@zh-mo
1989年論文
@zh-tw
1989年论文
@wuu
name
Nef protein of human immunodef ...... s a transcriptional inhibitor.
@ast
Nef protein of human immunodef ...... s a transcriptional inhibitor.
@en
Nef protein of human immunodef ...... s a transcriptional inhibitor.
@nl
type
label
Nef protein of human immunodef ...... s a transcriptional inhibitor.
@ast
Nef protein of human immunodef ...... s a transcriptional inhibitor.
@en
Nef protein of human immunodef ...... s a transcriptional inhibitor.
@nl
prefLabel
Nef protein of human immunodef ...... s a transcriptional inhibitor.
@ast
Nef protein of human immunodef ...... s a transcriptional inhibitor.
@en
Nef protein of human immunodef ...... s a transcriptional inhibitor.
@nl
P2093
P2860
P356
P1476
Nef protein of human immunodef ...... s a transcriptional inhibitor.
@en
P2093
P2860
P304
P356
10.1073/PNAS.86.23.9549
P407
P577
1989-12-01T00:00:00Z