The cytoskeletal protein talin contains at least two distinct vinculin binding domains
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Layilin, a novel talin-binding transmembrane protein homologous with C-type lectins, is localized in membrane rufflesStructural basis for amplifying vinculin activation by talinStructural Determinants of Integrin Binding to the Talin RodTalin contains three similar vinculin-binding sites predicted to form an amphipathic helixA fluorescence cell biology approach to map the second integrin-binding site of talin to a 130-amino acid sequence within the rod domain.Developmental regulation of focal contact protein expression in human melanocytes.The integrin binding site 2 (IBS2) in the talin rod domain is essential for linking integrin beta subunits to the cytoskeleton.α-actinin is required for the proper assembly of Z-disk/focal-adhesion-like structures and for efficient locomotion in Caenorhabditis elegans.Talin and vinculin play distinct roles in filopodial motility in the neuronal growth cone.Vinculin is part of the cadherin-catenin junctional complex: complex formation between alpha-catenin and vinculin.Isolation of peptides from phage-displayed random peptide libraries that interact with the talin-binding domain of vinculin.Talin requires beta-integrin, but not vinculin, for its assembly into focal adhesion-like structures in the nematode Caenorhabditis elegans.Specific beta1 integrin site selectively regulates Akt/protein kinase B signaling via local activation of protein phosphatase 2A.Interaction of the 47-kDa talin fragment and the 32-kDa vinculin fragment with acidic phospholipids: a computer analysisDomain interplay in the urokinase receptor. Requirement for the third domain in high affinity ligand binding and demonstration of ligand contact sites in distinct receptor domains.Disruption of the talin gene compromises focal adhesion assembly in undifferentiated but not differentiated embryonic stem cellsA talin homologue of Dictyostelium rapidly assembles at the leading edge of cells in response to chemoattractant.Further characterization of the interaction between the cytoskeletal proteins talin and vinculin.The activity of the vinculin binding sites in talin is influenced by the stability of the helical bundles that make up the talin rod.Tension development during contractile stimulation of smooth muscle requires recruitment of paxillin and vinculin to the membrane.Mapping and consensus sequence identification for multiple vinculin binding sites within the talin rod.Energy-filtered electron microscopy reveals that talin is a highly flexible protein composed of a series of globular domains.Identification of a Talin-binding Site in the Integrin β3Subunit Distinct from the NPLY Regulatory Motif of Post-ligand Binding FunctionsBinding of the Cytoplasmic Domain of Intercellular Adhesion Molecule-2 (ICAM-2) to α-Actinin
P2860
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P2860
The cytoskeletal protein talin contains at least two distinct vinculin binding domains
description
1993 nî lūn-bûn
@nan
1993 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
1993 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
1993年の論文
@ja
1993年論文
@yue
1993年論文
@zh-hant
1993年論文
@zh-hk
1993年論文
@zh-mo
1993年論文
@zh-tw
1993年论文
@wuu
name
The cytoskeletal protein talin contains at least two distinct vinculin binding domains
@ast
The cytoskeletal protein talin contains at least two distinct vinculin binding domains
@en
The cytoskeletal protein talin contains at least two distinct vinculin binding domains
@nl
type
label
The cytoskeletal protein talin contains at least two distinct vinculin binding domains
@ast
The cytoskeletal protein talin contains at least two distinct vinculin binding domains
@en
The cytoskeletal protein talin contains at least two distinct vinculin binding domains
@nl
prefLabel
The cytoskeletal protein talin contains at least two distinct vinculin binding domains
@ast
The cytoskeletal protein talin contains at least two distinct vinculin binding domains
@en
The cytoskeletal protein talin contains at least two distinct vinculin binding domains
@nl
P2093
P2860
P356
P1476
The cytoskeletal protein talin contains at least two distinct vinculin binding domains
@en
P2093
P2860
P304
P356
10.1083/JCB.122.2.337
P407
P577
1993-07-01T00:00:00Z