Alzheimer-associated presenilins 1 and 2: neuronal expression in brain and localization to intracellular membranes in mammalian cells. - Wikidata - wikimedia - TriplyDB

Alzheimer-associated presenilins 1 and 2: neuronal expression in brain and localization to intracellular membranes in mammalian cells.

Alzheimer-associated presenilins 1 and 2: neuronal expression in brain and localization to intracellular membranes in mammalian cells.

http://www.wikidata.org/entity/Q34372665

about

A myristoylated calcium-binding protein that preferentially interacts with the Alzheimer's disease presenilin 2 protein Identification of ubiquilin, a novel presenilin interactor that increases presenilin protein accumulation A presenilin-1/gamma-secretase cleavage releases the E-cadherin intracellular domain and regulates disassembly of adherens junctions.The novel presenilin-1-associated protein is a proapoptotic mitochondrial protein Interaction between amyloid precursor protein and presenilins in mammalian cells: implications for the pathogenesis of Alzheimer disease Syntaxin 5 interacts with presenilin holoproteins, but not with their N- or C-terminal fragments, and affects beta-amyloid peptide production The presenilin 2 mutation (N141I) linked to familial Alzheimer disease (Volga German families) increases the secretion of amyloid beta protein ending at the 42nd (or 43rd) residue Interaction of presenilins with the filamin family of actin-binding proteins delta-catenin, an adhesive junction-associated protein which promotes cell scattering Genetic of Alzheimer's Disease: A Narrative Review Article APP processing in Alzheimer's disease Direct interaction of Alzheimer's disease-related presenilin 1 with armadillo protein p0071 PAPIN. A novel multiple PSD-95/Dlg-A/ZO-1 protein interacting with neural plakophilin-related armadillo repeat protein/delta-catenin and p0071 Presenilin 1 regulates beta-catenin-mediated transcription in a glycogen synthase kinase-3-independent fashion Assembly, trafficking and function of gamma-secretase Aggresomes: a cellular response to misfolded proteins Neurotrophic factors [activity-dependent neurotrophic factor (ADNF) and basic fibroblast growth factor (bFGF)] interrupt excitotoxic neurodegenerative cascades promoted by a PS1 mutation Mice lacking both presenilin genes exhibit early embryonic patterning defects Presenilin 1 suppresses the function of c-Jun homodimers via interaction with QM/Jif-1 Identification of caspases that cleave presenilin-1 and presenilin-2 Differential release of β-amyloid from dendrite- versus axon-targeted APP.Human brain carboxypeptidase B, which cleaves beta-amyloid peptides in vitro, is expressed in the endoplasmic reticulum of neurons.Endogenous presenilin 1 redistributes to the surface of lamellipodia upon adhesion of Jurkat cells to a collagen matrix.Presenilin-1 C410Y Alzheimer disease plaques contain synaptic proteins.Alzheimer's disease-associated presenilin 2 interacts with DRAL, an LIM-domain protein.Characterization of age-dependent and progressive cortical neuronal degeneration in presenilin conditional mutant mice.The amyloid precursor protein of Alzheimer's disease and the Abeta peptide.Evidence for functional and physical association between Caenorhabditis elegans SEL-10, a Cdc4p-related protein, and SEL-12 presenilin The role of cell cycle-mediated events in Alzheimer's disease.The seven-transmembrane spanning topography of the Alzheimer disease-related presenilin proteins in the plasma membranes of cultured cells.A genetic dichotomy model for the inheritance of Alzheimer's disease and common age-related disorders Abnormalities of Mitochondrial Dynamics in Neurodegenerative Diseases.The genetic architecture of Alzheimer's disease: beyond APP, PSENs and APOE.Amyloid precursor protein (APP) mediated regulation of ganglioside homeostasis linking Alzheimer's disease pathology with ganglioside metabolism.Presenilin-1 regulates the constitutive turnover of the fibronectin matrix in endothelial cells Secretases as targets for drug design in Alzheimer's disease.Genetics of Alzheimer disease Neurons bearing presenilins: weapons for defense or suicide?Presenilin is necessary for efficient proteolysis through the autophagy-lysosome system in a γ-secretase-independent manner.Loss of presenilin 2 is associated with increased iPLA2 activity and lung tumor development.

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Alzheimer-associated presenilins 1 and 2: neuronal expression in brain and localization to intracellular membranes in mammalian cells.

http://www.wikidata.org/entity/Q34372665

description

1996 nî lūn-bûn

@nan

1996 թուականի Փետրուարին հրատարակուած գիտական յօդուած

@hyw

1996 թվականի փետրվարին հրատարակված գիտական հոդված

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1996年の論文

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1996年論文

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1996年論文

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1996年論文

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1996年論文

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1996年論文

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1996年论文

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name

Alzheimer-associated presenili ...... membranes in mammalian cells.

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Alzheimer-associated presenili ...... membranes in mammalian cells.

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Alzheimer-associated presenili ...... membranes in mammalian cells.

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type

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Alzheimer-associated presenili ...... membranes in mammalian cells.

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Alzheimer-associated presenili ...... membranes in mammalian cells.

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Alzheimer-associated presenili ...... membranes in mammalian cells.

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Alzheimer-associated presenili ...... membranes in mammalian cells.

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Alzheimer-associated presenili ...... membranes in mammalian cells.

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Nature Medicine

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Alzheimer-associated presenili ...... r membranes in mammalian cells

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P2093

B T Hyman

http://www.w3.org/2001/XMLSchema#string

D E Merriam

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D M Kovacs

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H J Fausett

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224-229

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scholarly article

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10.1038/NM0296-224

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2

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2

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14625509

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8574969

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P921

Alzheimer's disease