Genetic protection from the inflammatory disease type 1 diabetes in humans and animal models.
about
Central role of defective interleukin-2 production in the triggering of islet autoimmune destructionSignaling advances from immunogenetics to immunogenomicsThe Non-Obese Diabetic Mouse Strain as a Model to Study CD8(+) T Cell Function in Relapsing and Progressive Multiple SclerosisCrystal structure of HLA-DQ0602 that protects against type 1 diabetes and confers strong susceptibility to narcolepsyExperimental Diabetes Mellitus in Different Animal ModelsFunctional evidence for the mediation of diabetogenic T cell responses by HLA-A2.1 MHC class I molecules through transgenic expression in NOD mice.Novel analytical methods applied to type 1 diabetes genome-scan data.Sequencing and association analysis of the type 1 diabetes-linked region on chromosome 10p12-q11.MultiRTA: a simple yet reliable method for predicting peptide binding affinities for multiple class II MHC allotypes.Molecular pathway alterations in CD4 T-cells of nonobese diabetic (NOD) mice in the preinsulitis phase of autoimmune diabetes.Towards universal structure-based prediction of class II MHC epitopes for diverse allotypes.A novel pancreatic β-cell targeting bispecific-antibody (BsAb) can prevent the development of type 1 diabetes in NOD miceLocalization of a type 1 diabetes locus in the IL2RA/CD25 region by use of tag single-nucleotide polymorphisms.T-cell regulation by casitas B-lineage lymphoma (Cblb) is a critical failsafe against autoimmune disease due to autoimmune regulator (Aire) deficiency.The use of animal models in diabetes research.Molecular phenotyping of immune cells from young NOD mice reveals abnormal metabolic pathways in the early induction phase of autoimmune diabetesAlteration of intra-pancreatic target-organ specificity by abrogation of Aire in NOD mice.Zinc finger protein 467 is a novel regulator of osteoblast and adipocyte commitment.The nonconventional MHC class II molecule DM governs diabetes susceptibility in NOD miceNatural killer cells from children with type 1 diabetes have defects in NKG2D-dependent function and signalingGenetic vaccination for re-establishing T-cell tolerance in type 1 diabetes.Prevention of "Humanized" diabetogenic CD8 T-cell responses in HLA-transgenic NOD mice by a multipeptide coupled-cell approachHLA-A2-matched peripheral blood mononuclear cells from type 1 diabetic patients, but not nondiabetic donors, transfer insulitis to NOD-scid/γc(null)/HLA-A2 transgenic mice concurrent with the expansion of islet-specific CD8+ T cells.Signatures of human regulatory T cells: an encounter with old friends and new playersImpairment of organ-specific T cell negative selection by diabetes susceptibility genes: genomic analysis by mRNA profilingHumanized animal models for autoimmune diseases.Exploring the genetic basis of disease using RNA interference.Evidence for a primary islet autoantigen (preproinsulin 1) for insulitis and diabetes in the nonobese diabetic mouse.Susceptible MHC alleles, not background genes, select an autoimmune T cell reactivity.The good turned ugly: immunopathogenic basis for diabetogenic CD8+ T cells in NOD mice.Enhancement of 26S proteasome functionality connects oxidative stress and vascular endothelial inflammatory response in diabetes mellitus.Genetic Background Specific Hypoxia Resistance in Rat is Correlated with Balanced Activation of a Cross-Chromosomal Genetic Network Centering on Physiological Homeostasis.Immunotherapy for the prevention and treatment of type 1 diabetes.Failure to censor forbidden clones of CD4 T cells in autoimmune diabetes.Restricted MHC-peptide repertoire predisposes to autoimmunity.MHC class II proteins and disease: a structural perspective.The use of genomewide ENU mutagenesis screens to unravel complex mammalian traits: identifying genes that regulate organ-specific and systemic autoimmunity.Glutamic acid decarboxylase-specific CD4+ regulatory T cells.Loss of T cell progenitor checkpoint control underlies leukemia initiation in Rag1-deficient nonobese diabetic mice.Identification of novel IGRP epitopes targeted in type 1 diabetes patients.
P2860
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P2860
Genetic protection from the inflammatory disease type 1 diabetes in humans and animal models.
description
2001 nî lūn-bûn
@nan
2001 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年学术文章
@wuu
2001年学术文章
@zh-cn
2001年学术文章
@zh-hans
2001年学术文章
@zh-my
2001年学术文章
@zh-sg
2001年學術文章
@yue
name
Genetic protection from the in ...... s in humans and animal models.
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Genetic protection from the in ...... s in humans and animal models.
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Genetic protection from the in ...... s in humans and animal models.
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type
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Genetic protection from the in ...... s in humans and animal models.
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Genetic protection from the in ...... s in humans and animal models.
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Genetic protection from the in ...... s in humans and animal models.
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prefLabel
Genetic protection from the in ...... s in humans and animal models.
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Genetic protection from the in ...... s in humans and animal models.
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Genetic protection from the in ...... s in humans and animal models.
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P1433
P1476
Genetic protection from the in ...... s in humans and animal models.
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P2093
P304
P356
10.1016/S1074-7613(01)00202-3
P407
P577
2001-09-01T00:00:00Z