Fueling open-source drug discovery: 177 small-molecule leads against tuberculosis. - Wikidata - wikimedia - TriplyDB

Fueling open-source drug discovery: 177 small-molecule leads against tuberculosis.

Fueling open-source drug discovery: 177 small-molecule leads against tuberculosis.

http://www.wikidata.org/entity/Q34544301

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Open drug discovery for the Zika virus Next-generation antimicrobials: from chemical biology to first-in-class drugs An Overview of the Challenges in Designing, Integrating, and Delivering BARD: A Public Chemical-Biology Resource and Query Portal for Multiple Organizations, Locations, and Disciplines The ChEMBL bioactivity database: an update A virtual screen discovers novel, fragment-sized inhibitors of Mycobacterium tuberculosis InhA Learning from the past for TB drug discovery in the future New target prediction and visualization tools incorporating open source molecular fingerprints for TB Mobile 2.0 BioPhytMol: a drug discovery community resource on anti-mycobacterial phytomolecules and plant extracts Synthesis and structural activity relationship study of antitubercular carboxamides A dual read-out assay to evaluate the potency of compounds active against Mycobacterium tuberculosis Tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide and N-benzyl-6',7'-dihydrospiro[piperidine-4,4'-thieno[3,2-c]pyran] analogues with bactericidal efficacy against Mycobacterium tuberculosis targeting MmpL3 Identification of new drug targets and resistance mechanisms in Mycobacterium tuberculosis Target prediction for an open access set of compounds active against Mycobacterium tuberculosis Looking back to the future: predicting in vivo efficacy of small molecules versus Mycobacterium tuberculosis Efficient Synthesis and Anti-Tubercular Activity of a Series of Spirocycles: An Exercise in Open Science Identification and characterization of hundreds of potent and selective inhibitors of Trypanosoma brucei growth from a kinase-targeted library screening campaign Mycobacterial dihydrofolate reductase inhibitors identified using chemogenomic methods and in vitro validation Ligand-target prediction by structural network biology using nAnnoLyze Release of 50 new, drug-like compounds and their computational target predictions for open source anti-tubercular drug discovery Identification of New Molecular Entities (NMEs) as Potential Leads against Tuberculosis from Open Source Compound Repository Bigger data, collaborative tools and the future of predictive drug discovery Novel inhibitors of Mycobacterium tuberculosis GuaB2 identified by a target based high-throughput phenotypic screen Identification of KasA as the cellular target of an anti-tubercular scaffold Comparative Study of Activities of a Diverse Set of Antimycobacterial Agents against Mycobacterium tuberculosis and Mycobacterium ulcerans Is Open Science the Future of Drug Development?DNA sequence-selective C8-linked pyrrolobenzodiazepine-heterocyclic polyamide conjugates show anti-tubercular-specific activities.Fusing dual-event data sets for Mycobacterium tuberculosis machine learning models and their evaluation.Are bigger data sets better for machine learning? Fusing single-point and dual-event dose response data for Mycobacterium tuberculosis Machine Learning Model Analysis and Data Visualization with Small Molecules Tested in a Mouse Model of Mycobacterium tuberculosis Infection (2014-2015).Insights into Integrated Lead Generation and Target Identification in Malaria and Tuberculosis Drug Discovery.Lansoprazole is an antituberculous prodrug targeting cytochrome bc1.Novel insights into the mechanism of inhibition of MmpL3, a target of multiple pharmacophores in Mycobacterium tuberculosis.Identification of novel inhibitors of nonreplicating Mycobacterium tuberculosis using a carbon starvation model Combining computational methods for hit to lead optimization in Mycobacterium tuberculosis drug discovery.Testing tuberculosis drug efficacy in a zebrafish high-throughput translational medicine screen The tuberculosis drug discovery and development pipeline and emerging drug targets.Thermodynamic Proxies to Compensate for Biases in Drug Discovery Methods.A Focused Screen Identifies Antifolates with Activity on Mycobacterium tuberculosis.A new piperidinol derivative targeting mycolic acid transport in Mycobacterium abscessus.Synthesis and Evaluation of the 2-Aminothiazoles as Anti-Tubercular Agents.

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P2860

Fueling open-source drug discovery: 177 small-molecule leads against tuberculosis.

http://www.wikidata.org/entity/Q34544301

description

2013 nî lūn-bûn

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2013 թուականի Յունուարին հրատարակուած գիտական յօդուած

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2013 թվականի հունվարին հրատարակված գիտական հոդված

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2013年の論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年论文

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name

Fueling open-source drug discovery: 177 small-molecule leads against tuberculosis.

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Fueling open-source drug discovery: 177 small-molecule leads against tuberculosis.

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Fueling open-source drug discovery: 177 small-molecule leads against tuberculosis.

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Fueling open-source drug discovery: 177 small-molecule leads against tuberculosis.

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Fueling open-source drug discovery: 177 small-molecule leads against tuberculosis.

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Fueling open-source drug discovery: 177 small-molecule leads against tuberculosis.

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Fueling open-source drug discovery: 177 small-molecule leads against tuberculosis.

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Fueling open-source drug discovery: 177 small-molecule leads against tuberculosis.

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Fueling open-source drug discovery: 177 small-molecule leads against tuberculosis.

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Fueling open-source drug discovery: 177 small-molecule leads against tuberculosis.

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Alfonso Mendoza

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Angel Santos-Villarejo

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Benigno Crespo

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Daniel Alvarez-Gomez

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David Barros

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Delia Blanco

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Emilio Alvarez-Ruiz

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Esther Pérez-Herran

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Francisco Javier Gamo-Benito

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Jaime Escribano

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P2860

The complete genome sequence of Mycobacterium bovis

Thousands of chemical starting points for antimalarial lead identification

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

Inhibition of mycolic acid transport across the Mycobacterium tuberculosis plasma membrane

Drugs for bad bugs: confronting the challenges of antibacterial discovery

Discovery and validation of new antitubercular compounds as potential drug leads and probes.

High-throughput screening for inhibitors of Mycobacterium tuberculosis H37Rv.

Antituberculosis activity of the molecular libraries screening center network library.

Fast standardized therapeutic-efficacy assay for drug discovery against tuberculosis.

Getting physical in drug discovery: a contemporary perspective on solubility and hydrophobicity.

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313-321

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scholarly article

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10.1002/CMDC.201200428

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2

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8

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José Francisco García-Bustos

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2013-01-10T00:00:00Z

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234105727

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23307663

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open-source software

Akafuba bulwadde

open-source drug discovery

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3743164

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