ATM-Chk2-p53 activation prevents tumorigenesis at an expense of organ homeostasis upon Brca1 deficiency - Wikidata - wikimedia - TriplyDB

ATM-Chk2-p53 activation prevents tumorigenesis at an expense of organ homeostasis upon Brca1 deficiency

ATM-Chk2-p53 activation prevents tumorigenesis at an expense of organ homeostasis upon Brca1 deficiency

http://www.wikidata.org/entity/Q34619732

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BRCA1 affects global DNA methylation through regulation of DNMT1 Two faces of p53: aging and tumor suppression Trial Watch: Targeting ATM-CHK2 and ATR-CHK1 pathways for anticancer therapy A selective requirement for 53BP1 in the biological response to genomic instability induced by Brca1 deficiency BRCA1 and Oxidative Stress Chk2 suppresses the oncogenic potential of DNA replication-associated DNA damage 53BP1 inhibits homologous recombination in Brca1-deficient cells by blocking resection of DNA breaks The yin-yang of DNA damage response: roles in tumorigenesis and cellular senescence.Role of BRCA1 in brain development.Crosstalk between the DNA damage response, histone modifications and neovascularisation.Wild-type BRCA1, but not mutated BRCA1, regulates the expression of the nuclear form of beta-catenin Cooperative functions of Chk1 and Chk2 reduce tumour susceptibility in vivo Low levels of 3,3'-diindolylmethane activate estrogen receptor α and induce proliferation of breast cancer cells in the absence of estradiol.PARP-1 inhibitors: are they the long-sought genetically specific drugs for BRCA1/2-associated breast cancers?SIRT1 suppresses the senescence-associated secretory phenotype through epigenetic gene regulation.Metformin and the ATM DNA damage response (DDR): accelerating the onset of stress-induced senescence to boost protection against cancer A dual role of BRCA1 in two distinct homologous recombination mediated repair in response to replication arrest.Cell cycle- and DNA repair pathway-specific effects of apoptosis on tumor suppression.BRCA1 loss activates cathepsin L-mediated degradation of 53BP1 in breast cancer cells.Mouse models of BRCA1 and BRCA2 deficiency: past lessons, current understanding and future prospects.The role of BRCA1 in homologous recombination repair in response to replication stress: significance in tumorigenesis and cancer therapy The ATM signaling network in development and disease.BRG1 is required for formation of senescence-associated heterochromatin foci induced by oncogenic RAS or BRCA1 loss Interplay among BRCA1, SIRT1, and Survivin during BRCA1-associated tumorigenesis.Death receptor-induced activation of the Chk2- and histone H2AX-associated DNA damage response pathways.BRCA1 and BRCA2: different roles in a common pathway of genome protection.Impaired skin and mammary gland development and increased gamma-irradiation-induced tumorigenesis in mice carrying a mutation of S1152-ATM phosphorylation site in Brca1.Taking the time to make important decisions: the checkpoint effector kinases Chk1 and Chk2 and the DNA damage response.The MRE11 complex: starting from the ends.p16INK4a suppresses BRCA1-deficient mammary tumorigenesis.Mouse models of BRCA1 and their application to breast cancer research.DNA double-strand break repair as determinant of cellular radiosensitivity to killing and target in radiation therapy.p16 loss rescues functional decline of Brca1-deficient mammary stem cells.CHEK2 genomic and proteomic analyses reveal genetic inactivation or endogenous activation across the 60 cell lines of the US National Cancer Institute.Working together and apart: the twisted relationship of the Mre11 complex and Chk2 in apoptosis and tumor suppression.Germline mutation of Brca1 alters the fate of mammary luminal cells and causes luminal-to-basal mammary tumor transformation.Unexpected functional similarities between gatekeeper tumour suppressor genes and proto-oncogenes revealed by systems biology.Cancer gets the Chk'ered flag.Replication Stress Shapes a Protective Chromatin Environment across Fragile Genomic Regions.ATM loss leads to synthetic lethality in BRCA1 BRCT mutant mice associated with exacerbated defects in homology-directed repair.

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ATM-Chk2-p53 activation prevents tumorigenesis at an expense of organ homeostasis upon Brca1 deficiency

http://www.wikidata.org/entity/Q34619732

description

2006 nî lūn-bûn

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2006 թուականի Մայիսին հրատարակուած գիտական յօդուած

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2006 թվականի մայիսին հրատարակված գիտական հոդված

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2006年の論文

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2006年論文

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ATM-Chk2-p53 activation preven ...... eostasis upon Brca1 deficiency

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ATM-Chk2-p53 activation preven ...... eostasis upon Brca1 deficiency

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ATM-Chk2-p53 activation preven ...... eostasis upon Brca1 deficiency

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ATM-Chk2-p53 activation preven ...... eostasis upon Brca1 deficiency

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ATM-Chk2-p53 activation preven ...... eostasis upon Brca1 deficiency

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ATM-Chk2-p53 activation preven ...... eostasis upon Brca1 deficiency

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ATM-Chk2-p53 activation preven ...... eostasis upon Brca1 deficiency

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ATM-Chk2-p53 activation preven ...... eostasis upon Brca1 deficiency

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ATM-Chk2-p53 activation preven ...... eostasis upon Brca1 deficiency

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SJ.EMBOJ.7601115

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The EMBO Journal

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ATM-Chk2-p53 activation preven ...... eostasis upon Brca1 deficiency

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Chu-Xia Deng

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Cuiying Xiao

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Hiroyuki Takai

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Joseph A De Soto

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Liu Cao

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Noboru Motoyama

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Rui-Hong Wang

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Sabine Mai

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Sangsoo Kim

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Stephen J Elledge

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P2860

Linkage of ATM to cell cycle regulation by the Chk2 protein kinase

Heterozygous germ line hCHK2 mutations in Li-Fraumeni syndrome

A biomarker that identifies senescent human cells in culture and in aging skin in vivo

Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint

BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures

Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis

Quantitative studies of the growth of mouse embryo cells in culture and their development into established lines

BRCA1: cell cycle checkpoint, genetic instability, DNA damage response and cancer evolution

DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139

DNA damage-induced activation of p53 by the checkpoint kinase Chk2

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2167-2177

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