Phosphorylation of thymidine and AZT in heart mitochondria: elucidation of a novel mechanism of AZT cardiotoxicity
about
The roles of HIV-1 proteins and antiretroviral drug therapy in HIV-1-associated endothelial dysfunctionLong-term AZT exposure alters the metabolic capacity of cultured human lymphoblastoid cellsHIV-1 polymerase inhibition by nucleoside analogs: cellular- and kinetic parameters of efficacy, susceptibility and resistance selectionNeurotoxic effects of AZT on developing and adult neurogenesisZidovudine induces downregulation of mitochondrial deoxynucleoside kinases: implications for mitochondrial toxicity of antiviral nucleoside analogs.3'-Azido-3'-deoxythymidine (AZT) inhibits thymidine phosphorylation in isolated rat liver mitochondria: a possible mechanism of AZT hepatotoxicity.3'-Azido-3'-deoxythymidine (AZT) is a competitive inhibitor of thymidine phosphorylation in isolated rat heart and liver mitochondria.Heart mitochondrial TTP synthesis and the compartmentalization of TMP.Antiretroviral nucleosides, deoxynucleotide carrier and mitochondrial DNA: evidence supporting the DNA pol gamma hypothesis.Zidovudine inhibits thymidine phosphorylation in the isolated perfused rat heart.Absence of a universal mechanism of mitochondrial toxicity by nucleoside analogs.Metabolism of deoxypyrimidines and deoxypyrimidine antiviral analogs in isolated brain mitochondriaMitochondrial disease in the offspring as a result of antiretroviral therapy.Effect of AZT on thymidine phosphorylation in cultured H9c2, U-937, and Raji cell lines.Intracellular pharmacokinetic study of zidovudine and its phosphorylated metabolites.Effects of zidovudine and stavudine on mitochondrial DNA of differentiating 3T3-F442a cells are not associated with imbalanced deoxynucleotide pools.Long-term exposure to AZT, but not d4T, increases endothelial cell oxidative stress and mitochondrial dysfunction.Nucleoside reverse transcriptase inhibitor toxicity and mitochondrial DNA.Adenosine 3',5'-cyclic monophosphate (cAMP)-dependent phosphoregulation of mitochondrial complex I is inhibited by nucleoside reverse transcriptase inhibitors.Bridging Functional and Structural Cardiotoxicity Assays Using Human Embryonic Stem Cell-Derived Cardiomyocytes for a More Comprehensive Risk Assessment.A computational model of mitochondrial AZT metabolism.Deoxynucleoside salvage enzymes and tissue specific mitochondrial DNA depletion.Origin of pyrimidine deoxyribonucleotide pools in perfused rat heart: implications for 3'-azido-3'-deoxythymidine-dependent cardiotoxicity.Off-Target Effects of Drugs that Disrupt Human Mitochondrial DNA Maintenance.Comparative phenotypic assessment of cardiac pathology, physiology, and gene expression in C3H/HeJ, C57BL/6J, and B6C3F1/J mice.
P2860
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P2860
Phosphorylation of thymidine and AZT in heart mitochondria: elucidation of a novel mechanism of AZT cardiotoxicity
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2004 nî lūn-bûn
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2004 թուականի Յունուարին հրատարակուած գիտական յօդուած
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2004 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2004年の論文
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2004年論文
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2004年論文
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2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
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name
Phosphorylation of thymidine a ...... echanism of AZT cardiotoxicity
@ast
Phosphorylation of thymidine a ...... echanism of AZT cardiotoxicity
@en
Phosphorylation of thymidine a ...... echanism of AZT cardiotoxicity
@nl
type
label
Phosphorylation of thymidine a ...... echanism of AZT cardiotoxicity
@ast
Phosphorylation of thymidine a ...... echanism of AZT cardiotoxicity
@en
Phosphorylation of thymidine a ...... echanism of AZT cardiotoxicity
@nl
prefLabel
Phosphorylation of thymidine a ...... echanism of AZT cardiotoxicity
@ast
Phosphorylation of thymidine a ...... echanism of AZT cardiotoxicity
@en
Phosphorylation of thymidine a ...... echanism of AZT cardiotoxicity
@nl
P2093
P2860
P356
P1476
Phosphorylation of thymidine a ...... echanism of AZT cardiotoxicity
@en
P2093
Alice T Bentley
Delia Susan-Resiga
Joel Gingerich
Matthew Hatch
P2860
P2888
P304
P356
10.1385/CT:4:2:155
P50
P577
2004-01-01T00:00:00Z
P5875
P6179
1011061464