3'-Azido-3'-deoxythymidine (AZT) inhibits thymidine phosphorylation in isolated rat liver mitochondria: a possible mechanism of AZT hepatotoxicity.
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An analysis of enzyme kinetics data for mitochondrial DNA strand termination by nucleoside reverse transcription inhibitorsThe kinetic effects on thymidine kinase 2 by enzyme-bound dTTP may explain the mitochondrial side effects of antiviral thymidine analogsZidovudine and Lamivudine for HIV Infection.A novel anti-HIV dextrin-zidovudine conjugate improving the pharmacokinetics of zidovudine in rats.3'-Azido-3'-deoxythymidine (AZT) is a competitive inhibitor of thymidine phosphorylation in isolated rat heart and liver mitochondria.Heart mitochondrial TTP synthesis and the compartmentalization of TMP.Zidovudine inhibits thymidine phosphorylation in the isolated perfused rat heart.Absence of a universal mechanism of mitochondrial toxicity by nucleoside analogs.Metabolism of deoxypyrimidines and deoxypyrimidine antiviral analogs in isolated brain mitochondriaAZT-induced mitochondrial toxicity: an epigenetic paradigm for dysregulation of gene expression through mitochondrial oxidative stressA novel (11)C-labeled thymidine analog, [(11)C]AZT, for tumor imaging by positron emission tomography.Effect of AZT on thymidine phosphorylation in cultured H9c2, U-937, and Raji cell lines.The role of mitochondrial and plasma membrane nucleoside transporters in drug toxicity.Effects of zidovudine and stavudine on mitochondrial DNA of differentiating 3T3-F442a cells are not associated with imbalanced deoxynucleotide pools.Mitochondrial DNA depletion in rat liver induced by fosalvudine tidoxil, a novel nucleoside reverse transcriptase inhibitor prodrugLong-term exposure to AZT, but not d4T, increases endothelial cell oxidative stress and mitochondrial dysfunction.BMS-986001, an HIV nucleoside reverse transcriptase inhibitor, does not degrade mitochondrial DNA in long-term primary cultures of cells isolated from human kidney, muscle, and adipose tissue.Early identification of clinically relevant drug interactions with the human bile salt export pump (BSEP/ABCB11).Increased mtDNA levels without change in mitochondrial enzymes in peripheral blood mononuclear cells of infants born to HIV-infected mothers on antiretroviral therapyMitochondrial purine and pyrimidine metabolism and beyond.Synthesis, cytotoxicity and cellular uptake studies of N3 functionalized Re(CO)3 thymidine complexes.Anticancer conjugates and cocktails based on methotrexate and nucleoside synergism.Synthesis, characterization, and in vitro assay of folic acid conjugates of 3'-azido-3'-deoxythymidine (AZT): toward targeted AZT based anticancer therapeutics.Origin of pyrimidine deoxyribonucleotide pools in perfused rat heart: implications for 3'-azido-3'-deoxythymidine-dependent cardiotoxicity.
P2860
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P2860
3'-Azido-3'-deoxythymidine (AZT) inhibits thymidine phosphorylation in isolated rat liver mitochondria: a possible mechanism of AZT hepatotoxicity.
description
2006 nî lūn-bûn
@nan
2006 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
3'-Azido-3'-deoxythymidine (AZ ...... chanism of AZT hepatotoxicity.
@ast
3'-Azido-3'-deoxythymidine (AZ ...... chanism of AZT hepatotoxicity.
@en
type
label
3'-Azido-3'-deoxythymidine (AZ ...... chanism of AZT hepatotoxicity.
@ast
3'-Azido-3'-deoxythymidine (AZ ...... chanism of AZT hepatotoxicity.
@en
prefLabel
3'-Azido-3'-deoxythymidine (AZ ...... chanism of AZT hepatotoxicity.
@ast
3'-Azido-3'-deoxythymidine (AZ ...... chanism of AZT hepatotoxicity.
@en
P2093
P2860
P1476
3'-Azido-3'-deoxythymidine (AZ ...... chanism of AZT hepatotoxicity.
@en
P2093
Alice T Bentley
Edward E McKee
Matthew D Lynx
P2860
P304
P356
10.1016/J.BCP.2006.01.003
P407
P577
2006-02-10T00:00:00Z