Rhomboid-7 and HtrA2/Omi act in a common pathway with the Parkinson's disease factors Pink1 and Parkin. - Wikidata - wikimedia - TriplyDB

Rhomboid-7 and HtrA2/Omi act in a common pathway with the Parkinson's disease factors Pink1 and Parkin.

Rhomboid-7 and HtrA2/Omi act in a common pathway with the Parkinson's disease factors Pink1 and Parkin.

http://www.wikidata.org/entity/Q34892238

about

PINK1 is selectively stabilized on impaired mitochondria to activate Parkin Bridging the gap between basic and applied biology: towards preclinical translation Functional alteration of PARL contributes to mitochondrial dysregulation in Parkinson's disease The mitochondrial intramembrane protease PARL cleaves human Pink1 to regulate Pink1 trafficking PINK1 cleavage at position A103 by the mitochondrial protease PARL.Dynamics of the rhomboid-like protein RHBDD2 expression in mouse retina and involvement of its human ortholog in retinitis pigmentosa The Parkinson's disease-linked proteins Fbxo7 and Parkin interact to mediate mitophagy Oxidative stress-induced signaling pathways implicated in the pathogenesis of Parkinson's disease PINK1 and Parkin – mitochondrial interplay between phosphorylation and ubiquitylation in Parkinson's disease Parkin structure and function Mitochondrial dynamics and mitophagy in Parkinson's disease: disordered cellular power plant becomes a big deal in a major movement disorder Mechanisms of mitophagy PINK1-Parkin pathway activity is regulated by degradation of PINK1 in the mitochondrial matrix Autophagosome dynamics in neurodegeneration at a glance Mitochondrial impairment increases FL-PINK1 levels by calcium-dependent gene expression Beyond mitophagy: cytosolic PINK1 as a messenger of mitochondrial health Drosophila HtrA2 is dispensable for apoptosis but acts downstream of PINK1 independently from Parkin Mitochondrial membrane potential regulates PINK1 import and proteolytic destabilization by PARL Drosophila parkin requires PINK1 for mitochondrial translocation and ubiquitinates mitofusin PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65 Silencing of PINK1 expression affects mitochondrial DNA and oxidative phosphorylation in dopaminergic cells.Novel mitochondrial substrates of omi indicate a new regulatory role in neurodegenerative disorders.Mitochondrial quality control: insights on how Parkinson's disease related genes PINK1, parkin, and Omi/HtrA2 interact to maintain mitochondrial homeostasis.A pivotal role for PINK1 and autophagy in mitochondrial quality control: implications for Parkinson disease.In silico survey of the mitochondrial protein uptake and maturation systems in the brown alga Ectocarpus siliculosus.Drosophila melanogaster in the study of human neurodegeneration.Keeping the immune system in check: a role for mitophagy.Mitochondrial quality control mediated by PINK1 and Parkin: links to parkinsonism.PINK1 drives Parkin self-association and HECT-like E3 activity upstream of mitochondrial binding Mitochondrial morphogenesis, distribution, and Parkinson disease: insights from PINK1 Mitochondrial dynamics and neurodegeneration Modulation of mitochondrial function and morphology by interaction of Omi/HtrA2 with the mitochondrial fusion factor OPA1.Drosophila models of Parkinson's disease: discovering relevant pathways and novel therapeutic strategies.Diversity in the regulation of autophagy and mitophagy: lessons from Parkinson's disease.Phosphorylation of HtrA2 by cyclin-dependent kinase-5 is important for mitochondrial function.Differential evolution of members of the rhomboid gene family with conservative and divergent patterns.Clueless, a protein required for mitochondrial function, interacts with the PINK1-Parkin complex in Drosophila Role of PINK1 binding to the TOM complex and alternate intracellular membranes in recruitment and activation of the E3 ligase Parkin Mitochondrial quality control and dynamics in Parkinson's disease The emerging role of proteolysis in mitochondrial quality control and the etiology of Parkinson's disease.

P2860

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P2860

Rhomboid-7 and HtrA2/Omi act in a common pathway with the Parkinson's disease factors Pink1 and Parkin.

http://www.wikidata.org/entity/Q34892238

description

2008 nî lūn-bûn

@nan

2008 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

@hyw

2008 թվականի սեպտեմբերին հրատարակված գիտական հոդված

@hy

2008年の論文

@ja

2008年論文

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2008年論文

@zh-hant

2008年論文

@zh-hk

2008年論文

@zh-mo

2008年論文

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2008年论文

@wuu

name

Rhomboid-7 and HtrA2/Omi act i ...... ease factors Pink1 and Parkin.

@ast

Rhomboid-7 and HtrA2/Omi act i ...... ease factors Pink1 and Parkin.

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Rhomboid-7 and HtrA2/Omi act i ...... ease factors Pink1 and Parkin.

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type

label

Rhomboid-7 and HtrA2/Omi act i ...... ease factors Pink1 and Parkin.

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Rhomboid-7 and HtrA2/Omi act i ...... ease factors Pink1 and Parkin.

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Rhomboid-7 and HtrA2/Omi act i ...... ease factors Pink1 and Parkin.

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prefLabel

Rhomboid-7 and HtrA2/Omi act i ...... ease factors Pink1 and Parkin.

@ast

Rhomboid-7 and HtrA2/Omi act i ...... ease factors Pink1 and Parkin.

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Rhomboid-7 and HtrA2/Omi act i ...... ease factors Pink1 and Parkin.

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P1433

Disease Models & Mechanisms

P1476

Rhomboid-7 and HtrA2/Omi act i ...... ease factors Pink1 and Parkin.

@en

P2093

G Angus McQuibban

http://www.w3.org/2001/XMLSchema#string

Jeffrey R Lee

http://www.w3.org/2001/XMLSchema#string

Robert Flick

http://www.w3.org/2001/XMLSchema#string

Ruhena Chowdhury

http://www.w3.org/2001/XMLSchema#string

Venus M-W Ho

http://www.w3.org/2001/XMLSchema#string

P2860

Hereditary early-onset Parkinson's disease caused by mutations in PINK1

Differential sublocalization of the dynamin-related protein OPA1 isoforms in mitochondria

Genome-wide screen for modifiers of ataxin-3 neurodegeneration in Drosophila

Mitochondrial membrane remodelling regulated by a conserved rhomboid protease.

Loss of function mutations in the gene encoding Omi/HtrA2 in Parkinson's disease

The mitochondrial serine protease HtrA2/Omi: an overview

Mitochondrial rhomboid PARL regulates cytochrome c release during apoptosis via OPA1-dependent cristae remodeling

Mitochondrial dysfunction and oxidative damage in parkin-deficient mice

Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin

Mitochondrial pathology and apoptotic muscle degeneration in Drosophila parkin mutants

P304

168-74; discussion 173

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scholarly article

P356

10.1242/DMM.000109

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2-3

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P478

1

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Alexander J. Whitworth

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2008-09-18T00:00:00Z

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23561008

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P698

19048081

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P921

Parkinson's disease

P932

2562193

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