Transient receptor potential mucolipin 1 (TRPML1) and two-pore channels are functionally independent organellar ion channels - Wikidata - wikimedia - TriplyDB

Transient receptor potential mucolipin 1 (TRPML1) and two-pore channels are functionally independent organellar ion channels

Transient receptor potential mucolipin 1 (TRPML1) and two-pore channels are functionally independent organellar ion channels

http://www.wikidata.org/entity/Q35067713

about

Two-pore channels form homo- and heterodimers Hax-1 identified as a two-pore channel (TPC)-binding protein Photoaffinity labeling of high affinity nicotinic acid adenine dinucleotide phosphate (NAADP)-binding proteins in sea urchin egg Photoaffinity labeling of nicotinic acid adenine dinucleotide phosphate (NAADP) targets in mammalian cells Domain assembly of NAADP-gated two-pore channels Expression of Ca²⁺-permeable two-pore channels rescues NAADP signalling in TPC-deficient cells TPC: the NAADP discovery channel?Membrane potential regulates nicotinic acid adenine dinucleotide phosphate (NAADP) dependence of the pH- and Ca2+-sensitive organellar two-pore channel TPC1 Two-pore channels (TPCs): current controversies Convergent regulation of the lysosomal two-pore channel-2 by Mg²⁺, NAADP, PI(3,5)P₂ and multiple protein kinases High resolution structural evidence suggests the Sarcoplasmic Reticulum forms microdomains with Acidic Stores (lysosomes) in the heart Nicotinic Acid Adenine Dinucleotide 2'-Phosphate (NAADP) Binding Proteins in T-Lymphocytes.Mitochondrial function and malfunction in the pathophysiology of pancreatitis.Function and dysfunction of two-pore channels.Rapid recycling of Ca2+ between IP3-sensitive stores and lysosomes Regulation of TRPML1 function.Acidic Ca2+ stores in neurodegeneration.The intracellular Ca²⁺ channels of membrane traffic.Nicotinic acid adenine dinucleotide phosphate (NAADP) activates global and heterogeneous local Ca2+ signals from NAADP- and ryanodine receptor-gated Ca2+ stores in pulmonary arterial myocytes Fusion of lysosomes with secretory organelles leads to uncontrolled exocytosis in the lysosomal storage disease mucolipidosis type IV.Cyclic ADP-Ribose and NAADP in Vascular Regulation and Diseases.Physiological roles of NAADP-mediated Ca2+ signaling.Molecular mechanisms of endolysosomal Ca2+ signalling in health and disease.Ca(2+) signals, NAADP and two-pore channels: role in cellular differentiation.Presenilin 1 Maintains Lysosomal Ca(2+) Homeostasis via TRPML1 by Regulating vATPase-Mediated Lysosome Acidification.Poring over two-pore channel pore mutants.Preferential Coupling of the NAADP Pathway to Exocytosis in T-Cells.Endo-lysosomal TRP mucolipin-1 channels trigger global ER Ca2+ release and Ca2+ influx.Questioning regulation of two-pore channels by NAADP Iron overload causes endolysosomal deficits modulated by NAADP-regulated 2-pore channels and RAB7A.How does NAADP release lysosomal Ca2+?BK channel agonist represents a potential therapeutic approach for lysosomal storage diseases.Calcium Signalling Triggered by NAADP in T Cells Determines Cell Shape and Motility During Immune Synapse Formation.Tuning the ion selectivity of two-pore channels.Cross-talk between TRPML1 channel, lipids and lysosomal storage diseases.Connecting Ca2+ and lysosomes to Parkinson disease.The Molecular Basis for Ca2+ Signalling by NAADP: Two-Pore Channels in a Complex?Direct mobilisation of lysosomal Ca2+ triggers complex Ca2+ signals.Lysosomal Calcium in Neurodegeneration.The N-terminal region of two-pore channel 1 regulates trafficking and activation by NAADP.

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Transient receptor potential mucolipin 1 (TRPML1) and two-pore channels are functionally independent organellar ion channels

http://www.wikidata.org/entity/Q35067713

description

2011 nî lūn-bûn

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2011 թուականի Մայիսին հրատարակուած գիտական յօդուած

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2011 թվականի մայիսին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年论文

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name

Transient receptor potential m ...... endent organellar ion channels

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Transient receptor potential m ...... endent organellar ion channels

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type

label

Transient receptor potential m ...... endent organellar ion channels

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Transient receptor potential m ...... endent organellar ion channels

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Transient receptor potential m ...... endent organellar ion channels

@ast

Transient receptor potential m ...... endent organellar ion channels

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JBC.M110.210930

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Journal of Biological Chemistry

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Transient receptor potential m ...... endent organellar ion channels

@en

P2093

Abigail A Soyombo

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Archana Jha

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Dev Churamani

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Eugen Brailoiu

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Qin Li

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Shmuel Muallem

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Soichiro Yamaguchi

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P2860

Essential requirement for two-pore channel 1 in NAADP-mediated calcium signaling

NAADP mobilizes calcium from acidic organelles through two-pore channels

Mutations in Mcoln3 associated with deafness and pigmentation defects in varitint-waddler (Va) mice.

TPC2 is a novel NAADP-sensitive Ca2+ release channel, operating as a dual sensor of luminal pH and Ca2+

Abnormal transport along the lysosomal pathway in mucolipidosis, type IV disease

A novel mode of TRPML3 regulation by extracytosolic pH absent in the varitint-waddler phenotype

NAADP mobilizes Ca(2+) from reserve granules, lysosome-related organelles, in sea urchin eggs

Cell-permeant NAADP: a novel chemical tool enabling the study of Ca2+ signalling in intact cells

An ancestral deuterostome family of two-pore channels mediates nicotinic acid adenine dinucleotide phosphate-dependent calcium release from acidic organelles

Acidic calcium stores open for business: expanding the potential for intracellular Ca2+ signaling

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22934-22942

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scholarly article

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10.1074/JBC.M110.210930

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26

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286

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George D. Dickinson

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2011-05-03T00:00:00Z

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21540176

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3123061

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