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Membrane-binding and activation mechanism of PTEN.

Membrane-binding and activation mechanism of PTEN.

http://www.wikidata.org/entity/Q35145882

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The role of hydrophobic interactions in positioning of peripheral proteins in membranes PTEN tumor suppressor associates with NHERF proteins to attenuate PDGF receptor signaling.Binding of PTEN to specific PDZ domains contributes to PTEN protein stability and phosphorylation by microtubule-associated serine/threonine kinases Prdx1 inhibits tumorigenesis via regulating PTEN/AKT activity Cardiac regulation by phosphoinositide 3-kinases and PTEN Increased insulin action in SKIP heterozygous knockout mice The type Ialpha inositol polyphosphate 4-phosphatase generates and terminates phosphoinositide 3-kinase signals on endosomes and the plasma membrane PTEN function: how normal cells control it and tumour cells lose it PTEN as an effector in the signaling of antimigratory G protein-coupled receptor The neurosecretory vesicle protein phogrin functions as a phosphatidylinositol phosphatase to regulate insulin secretion Critical role of PICT-1, a tumor suppressor candidate, in phosphatidylinositol 3,4,5-trisphosphate signals and tumorigenic transformation Focus on PTEN Regulation Biophysical methods for the characterization of PTEN/lipid bilayer interactions PtdIns(4,5)P2-mediated cell signaling: emerging principles and PTEN as a paradigm for regulatory mechanism Phosphoinositides: tiny lipids with giant impact on cell regulation Superdiffusive motion of membrane-targeting C2 domains.PTEN hopping on the cell membrane is regulated via a positively-charged C2 domain Key role of local regulation in chemosensing revealed by a new molecular interaction-based modeling method.Crystal Structure of the Cytoplasmic Phosphatase and Tensin Homolog (PTEN)-like Region of Ciona intestinalis Voltage-sensing Phosphatase Provides Insight into Substrate Specificity and Redox Regulation of the Phosphoinositide Phosphatase Activity Voltage sensitive phosphatases: emerging kinship to protein tyrosine phosphatases from structure-function research Novel mechanism of PTEN regulation by its phosphatidylinositol 4,5-bisphosphate binding motif is critical for chemotaxis Membrane recruitment of scaffold proteins drives specific signaling Differential regulation of proton-sensitive ion channels by phospholipids: a comparative study between ASICs and TRPV1 A functional dissection of PTEN N-terminus: implications in PTEN subcellular targeting and tumor suppressor activity Nuclear localization of PTEN by a Ran-dependent mechanism enhances apoptosis: Involvement of an N-terminal nuclear localization domain and multiple nuclear exclusion motifs Phenotype selection reveals coevolution of muscle glycogen and protein and PTEN as a gate keeper for the accretion of muscle mass in adult female mice Regulation of PTEN phosphorylation and stability by a tumor suppressor candidate protein.The determinants of head and neck cancer: Unmasking the PI3K pathway mutations Membrane association of the PTEN tumor suppressor: electrostatic interaction with phosphatidylserine-containing bilayers and regulatory role of the C-terminal tail.Two complementary, local excitation, global inhibition mechanisms acting in parallel can explain the chemoattractant-induced regulation of PI(3,4,5)P3 response in dictyostelium cells.A novel leptin signalling pathway via PTEN inhibition in hypothalamic cell lines and pancreatic beta-cells.Membrane association of the PTEN tumor suppressor: molecular details of the protein-membrane complex from SPR binding studies and neutron reflection Inhibition of cell motility by troglitazone in human ovarian carcinoma cell line.TGF-β induces phosphorylation of phosphatase and tensin homolog: implications for fibrosis of the trabecular meshwork tissue in glaucoma Arrestin and the multi-PDZ domain-containing protein MPZ-1 interact with phosphatase and tensin homolog (PTEN) and regulate Caenorhabditis elegans longevity.Opposite effects of HIV-1 p17 variants on PTEN activation and cell growth in B cells.Engineering ePTEN, an enhanced PTEN with increased tumor suppressor activities.Profilin-1 overexpression upregulates PTEN and suppresses AKT activation in breast cancer cells.Honey bee PTEN--description, developmental knockdown, and tissue-specific expression of splice-variants correlated with alternative social phenotypes.Characterization of a novel PTEN mutation in MDA-MB-453 breast carcinoma cell line

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P2860

Membrane-binding and activation mechanism of PTEN.

http://www.wikidata.org/entity/Q35145882

description

2003 nî lūn-bûn

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2003 թուականի Յունիսին հրատարակուած գիտական յօդուած

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2003 թվականի հունիսին հրատարակված գիտական հոդված

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2003年の論文

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2003年論文

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2003年論文

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2003年論文

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2003年論文

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2003年論文

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2003年论文

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name

Membrane-binding and activation mechanism of PTEN.

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Membrane-binding and activation mechanism of PTEN.

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Membrane-binding and activation mechanism of PTEN.

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Membrane-binding and activation mechanism of PTEN.

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Membrane-binding and activation mechanism of PTEN.

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Membrane-binding and activation mechanism of PTEN.

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Proceedings of the National Academy of Sciences of the United States of America

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Membrane-binding and activation mechanism of PTEN.

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Jack E Dixon

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Sudipto Das

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Wonhwa Cho

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P2860

The lipid phosphatase activity of PTEN is critical for its tumor supressor function

The tumor-suppressor activity of PTEN is regulated by its carboxyl-terminal region

Threonine phosphorylation of the MMAC1/PTEN PDZ binding domain both inhibits and stimulates PDZ binding

Interaction of the tumor suppressor PTEN/MMAC with a PDZ domain of MAGI3, a novel membrane-associated guanylate kinase

Evidence for regulation of the PTEN tumor suppressor by a membrane-localized multi-PDZ domain containing scaffold protein MAGI-2

Phosphorylation of the PTEN tail regulates protein stability and function

The tumor suppressor PTEN is phosphorylated by the protein kinase CK2 at its C terminus. Implications for PTEN stability to proteasome-mediated degradation

Binding of the PX domain of p47(phox) to phosphatidylinositol 3,4-bisphosphate and phosphatidic acid is masked by an intramolecular interaction

The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate

Crystal structure of the PTEN tumor suppressor: implications for its phosphoinositide phosphatase activity and membrane association

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