Residues crucial for maintaining short paths in network communication mediate signaling in proteins
about
Computational enzyme design approaches with significant biological outcomes: progress and challengesMolecular docking as a popular tool in drug design, an in silico travelUrzymology: experimental access to a key transition in the appearance of enzymesStructure and dynamics of molecular networks: a novel paradigm of drug discovery: a comprehensive reviewCommunication over the network of binary switches regulates the activation of A2A adenosine receptor"Fluctuograms" reveal the intermittent intra-protein communication in subtilisin Carlsberg and correlate mechanical coupling with co-evolutionPerturbation-based Markovian transmission model for probing allosteric dynamics of large macromolecular assembling: a study of GroEL-GroESAllosteric communication occurs via networks of tertiary and quaternary motions in proteinsSignal Transduction Pathways in the Pentameric Ligand-Gated Ion ChannelsThe modular organization of domain structures: insights into protein-protein bindingMechanisms of loss of functions of human angiogenin variants implicated in amyotrophic lateral sclerosisTowards structural systems pharmacology to study complex diseases and personalized medicineMolecular Determinants Underlying Binding Specificities of the ABL Kinase Inhibitors: Combining Alanine Scanning of Binding Hot Spots with Network Analysis of Residue Interactions and CoevolutionThe RING 2.0 web server for high quality residue interaction networksEmerging Computational Methods for the Rational Discovery of Allosteric Drugs.Small world network strategies for studying protein structures and binding.Computational modeling of allosteric regulation in the hsp90 chaperones: a statistical ensemble analysis of protein structure networks and allosteric communications.Thermostability of in vitro evolved Bacillus subtilis lipase A: a network and dynamics perspective.Seeing the results of a mutation with a vertex weighted hierarchical graph.Optimized null model for protein structure networks.Substrate uptake and protein stability relationship in mammalian histidine decarboxylase.Integration of evolutionary features for the identification of functionally important residues in major facilitator superfamily transportersMolecular dynamics simulations and modelling of the residue interaction networks in the BRAF kinase complexes with small molecule inhibitors: probing the allosteric effects of ligand-induced kinase dimerization and paradoxical activation.Vibrational resonance, allostery, and activation in rhodopsin-like G protein-coupled receptors.Exploring Molecular Mechanisms of Paradoxical Activation in the BRAF Kinase Dimers: Atomistic Simulations of Conformational Dynamics and Modeling of Allosteric Communication Networks and Signaling Pathways.Interaction energy based protein structure networksModeling allosteric signal propagation using protein structure networksWordom: a user-friendly program for the analysis of molecular structures, trajectories, and free energy surfaces.Exploiting a reduced set of weighted average features to improve prediction of DNA-binding residues from 3D structures.Role of long- and short-range hydrophobic, hydrophilic and charged residues contact network in protein's structural organization.Mapping the mutual information network of enzymatic families in the protein structure to unveil functional features.Computational modeling of allosteric communication reveals organizing principles of mutation-induced signaling in ABL and EGFR kinases.The energy landscape analysis of cancer mutations in protein kinasesAccurate prediction of the dynamical changes within the second PDZ domain of PTP1e.Recruitment of rare 3-grams at functional sites: is this a mechanism for increasing enzyme specificity?Prediction by graph theoretic measures of structural effects in proteins arising from non-synonymous single nucleotide polymorphisms.A combinatorial approach to detect coevolved amino acid networks in protein families of variable divergence.Structure-based predictive models for allosteric hot spots.Predicting important residues and interaction pathways in proteins using Gaussian Network Model: binding and stability of HLA proteins.Role of Hsp70 ATPase domain intrinsic dynamics and sequence evolution in enabling its functional interactions with NEFs.
P2860
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P2860
Residues crucial for maintaining short paths in network communication mediate signaling in proteins
description
2006 nî lūn-bûn
@nan
2006 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2006年の論文
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2006年学术文章
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2006年学术文章
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2006年学术文章
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2006年学术文章
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2006年学术文章
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2006年學術文章
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name
Residues crucial for maintaini ...... mediate signaling in proteins
@ast
Residues crucial for maintaini ...... mediate signaling in proteins
@en
type
label
Residues crucial for maintaini ...... mediate signaling in proteins
@ast
Residues crucial for maintaini ...... mediate signaling in proteins
@en
prefLabel
Residues crucial for maintaini ...... mediate signaling in proteins
@ast
Residues crucial for maintaini ...... mediate signaling in proteins
@en
P2093
P2860
P356
P1476
Residues crucial for maintaini ...... mediate signaling in proteins
@en
P2093
Antonio del Sol
Dolors Amoros
Hirotomo Fujihashi
P2860
P304
P356
10.1038/MSB4100063
P577
2006-05-02T00:00:00Z